Expression of COX-2, E-ca and VEGF-c in colorectal cancer and its significance

• DOI: 10.3760/cma.j.issn.1673-4203.2010.12.007
• Publication Date: 2010-12-15
• Authors: Min Xie; Kai T; Xia He-shun; Changming Wu

Objective To study the expression of cyclooxygenase-2,epithelial cadherin and vascular endothelial growth factor-c in colorectal cancer its significance. Methods Seventy-seven patients with were detected COX-2, E-ca nd VEGF-c by immunohistochemical SP method. Results COX-2 positive tissue was 24.7%; rate 68.8%; 84.4%. highly differentiated tissues significantly higher than poorly ones (P ＜0. 05); tubular adenocarcinoma mucous glands other types ( P ＜ 0. 05 ); The Positive stage Ⅰ + Ⅱ Ⅲ Ⅳ 005). protein negatively correlated ). Conclusion Combined detection COX-2,VEGF-c is helpful to recognize occurrence, development tratment cancer.

Key words: Colorectal cancer; Cyclooxygenase-2; Epithelial cadherin; Vascular