A5081759932- Endodontics and Root Canal Treatments
- Dental materials and restorations
- Dental Radiography and Imaging
- Bone and Dental Protein Studies
- Dental Erosion and Treatment
- Dental Trauma and Treatments
- dental development and anomalies
- Optical Coherence Tomography Applications
- Retinal Imaging and Analysis
- Dental Research and COVID-19
- Drilling and Well Engineering
- Retinal Diseases and Treatments
- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- 3D Printing in Biomedical Research
- Oral microbiology and periodontitis research
- Orthodontics and Dentofacial Orthopedics
- Laser Applications in Dentistry and Medicine
- Bone Metabolism and Diseases
- Glaucoma and retinal disorders
- Photopolymerization techniques and applications
- Oral and Maxillofacial Pathology
- Inflammatory mediators and NSAID effects
- Retinal and Optic Conditions
- Photoacoustic and Ultrasonic Imaging
Massachusetts Institute of Technology
2021-2025
Chonnam National University
2015-2024
Samsung (South Korea)
2023
Seoul National University
2017-2022
Gwangju Institute of Science and Technology
2018
University of Michigan
2010
Chonnam National University Hospital
2010
Adoptive cell transfer against solid tumors faces challenges to overcome tumor microenvironment (TME), which plays as a physical barrier and provides immuno-suppressive conditions. Classical cytotoxicity assays are widely used measure killing ability of the engineered cytotoxic lymphocytes therapeutics, but results cannot represent performance in clinical application due absence TME. This paper describes 3D Cytotoxicity Assay for Cancer Immunotherapy using an Injection Molded Plastic Array...
Microfluidic organ-on-a-chip technologies have enabled construction of biomimetic physiologically and pathologically relevant models. This paper describes an injection molded microfluidic platform that utilizes a novel sequential edge-guided patterning method based on spontaneous capillary flow to realize three-dimensional co-culture models form array micro-vascularized tissues (28 per 1 × 2-inch slide format). The MicroVascular Injection-Molded Plastic Array 3D Culture (MV-IMPACT) is...
The purpose of this study was to assess the ability two new calcium silicate-based pulp-capping materials (Biodentine and BioAggregate) induce healing in a rat pulp injury model compare them with mineral trioxide aggregate (MTA).Eighteen rats were anesthetized, cavities prepared capped either ProRoot MTA, Biodentine, or BioAggregate. specimens scanned using high-resolution micro-computed tomography (micro-CT) system evaluated histologically immunohistochemically dentin sialoprotein (DSP).On...
Abstract Aim To compare the mineralization inductive capacity of Biodentine and Bioaggregate with Mineral trioxide aggregate ( MTA ) to investigate possible signaling pathways in human dental pulp cells HDPC s). Methodology Viability s response Biodentine, Bioaggregate, was measured using 3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5 diphenyltetrazolium bromide. their potential induce odontoblast differentiation, expression dentine sialophosphoprotein DSPP matrix protein1 DMP 1) m RNA level evaluated by...
Abstract This study reports the development of prototype swept-source optical coherence tomography (SS-OCT) technology for imaging anterior eye. Advances in vertical-cavity surface-emitting laser (VCSEL) light sources, signal processing, optics and mechanical designs, enable a unique combination high speed, long range, deep penetration that addresses challenges eye imaging. We demonstrate SS-OCT with 325 kHz A-scan rate, 12.2 µm axial resolution (in air), 15.5 mm depth range air) at 1310 nm...
PurposeUltrahigh resolution spectral domain-OCT (UHR SD-OCT) enables in vivo visualization of micrometric structural markers which differentially associate with normal aging versus age-related macular degeneration (AMD). This study explores the hypothesis that UHR SD-OCT can detect and quantify sub-retinal pigment epithelium (RPE) deposits early AMD, separating AMD pathology from aging.DesignProspective cross-sectional study.ParticipantsA total 53 nonexudative (dry) eyes 39 patients, 63...
Optical coherence tomography angiography (OCTA) can visualize vasculature structures, but provides limited information about blood flow speed. Here, we present a second generation variable interscan time analysis (VISTA) OCTA, which evaluates quantitative surrogate marker for speed in vasculature. At the capillary level, spatially compiled OCTA and simple temporal autocorrelation model, ρ ( τ ) = exp(- ατ ), were used to evaluate decay constant, α , as marker. A 600 kHz A-scan rate...
A micrometer scale hyporeflective band within the retinal pigment epithelium basal lamina - Bruch's membrane complex (RPE-BL-BrM) was topographically measured in aging and age-related macular degeneration (AMD).
To evaluate visibility of a sub-band posterior to the external limiting membrane (ELM) and assess its age-associated variation. In retrospective cross-sectional study, normal eyes were imaged using high-resolution spectral-domain optical coherence tomography (SD-OCT) prototype (2.7-µm axial resolution). Volume fusion six sequential scans (each 500 × A-scans over 6 mm mm) was performed in motion correction volume reconstruction OCT (MoReOCT) framework enhance feature OCT. The subjects divided...
Purpose: To quantify the blood flow speed within retinal microaneurysms (MAs) and investigate relationship between clinical characteristics in eyes with diabetic retinopathy (DR). Methods: Variable interscan time analysis (VISTA) quantifies vasculature by measuring how fast optical coherence tomography (OCT) angiography (OCTA) saturates for different times. Macular OCTA imaging was performed DR using a high-speed swept-source OCT prototype instrument operating at 600-kHz A-scan rate. The...
Purpose: The purpose of this study was to propose an alternative statistical approach that addresses the issue multiplicity in microperimetry data analysis, offering a more balanced and sensitive measure efficacy gene therapy inherited retinal diseases (IRDs). Methods: We analyzed from phase II trial AGTC-501 patients with X-linked retinitis pigmentosa (XLRP). Macular Integrity Assessment (MAIA; CenterVue, Padova, Italy) device used evaluate test-retest repeatability. A binomial model...
The aim of this study was to evaluate the cytotoxicity, setting time and compressive strength MTA two novel tricalcium silicate-based endodontic materials, Bioaggregate (BA) Biodentine (BD).Cytotoxicity evaluated by using a 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-((phenylamino)carbonyl)-2H-tetrazolium hydroxide (XTT) assay. Measurements 9 heavy metals (arsenic, cadmium, chromium, copper, iron, lead, manganese, nickel, zinc) were performed inductively coupled plasma-mass spectrometry...