High-early-strength-concrete (HESC) made of Type III cement reaches approximately 50–70 % its design compressive strength in a day ambient conditions. Experimental investigations were this study to observe the effects temperature, curing time and concrete on accelerated development HESC. A total 210 HESC cylinders 100 × 200 mm tested for different strengths (30, 40 50 MPa) regimes (with maximum temperatures 20, 30, 40, 60 °C) at equivalent ages (9, 12, 18, 24, 36, 168 h). From series...

Study Region: Hapcheon and Seomjingang Basins, South Korea Focus: This study investigated the impacts of climate change on water supply reliability flood risk in two East Asian basins Korea. By employing three coupled hydrological reservoir operation models, analysis considered projections under SSP2-4.5 SSP5-8.5, projected using 12 global models. New Hydrological Insights: Our results indicated that SSP2-4.5, did not considerably decrease compared to historical period (1995–2014), whereas...

Abstract The pluripotency-related T-box family transcription factor TBX3 maintains mESC self-renewal and plays a key role in the development of several tissues, including heart, mammary glands, limbs, lungs. However, during porcine preimplantation embryo remains unclear. In our research, was knocked down by injecting dsRNA to explore function TBX3. expression gradually increases early embryonic development. knockdown resulted decreased rate four-cell blastocyst. Depletion level...

Abstract Two new organic–inorganic (O–I) hybrid materials are synthesized and used as insulating layers for thin‐film fully printed electronics using non‐vacuum, low‐temperature processing. The O–I composed of high‐permittivity (high‐k) oxide components, ZrO₂ TiO₂, combined with organic three‐arm structured amphiphilic components. These materials, designated UZr UTi, exhibited dielectric constants (k) 12.43 17.33, respectively. Thin films made both smooth surfaces, good performance,...

Plastics are widely used worldwide due to their convenience. However, microplastics (MPs) accumulation poses a serious threat ecosystem health. Therefore, understanding the effects of MPs on living organisms within native is crucial. Previous studies have primarily focused impacts in aquatic environments, whereas terrestrial ecosystems remained largely understudied. our study assessed soil by characterizing toxic earthworms (Eisenia fetida). Here, we exposed two representative plastics...

Basic fibroblast growth factor (bFGF) is a crucial sustaining human pluripotent stem cells (hPSCs). We designed this study to search the substitutive factors other than bFGF for maintenance of hPSCs by using placenta-derived conditioned medium without exogenous (hPCCM−), containing chemokine (C-X-C motif) receptor 2 (CXCR2) ligands, including interleukin (IL)-8 and growth-related oncogene α (GROα), which were developed on basis our previous studies. First, we confirmed that IL-8 and/or GROα...

Persistent organic pollutants (POPs) are lipid-soluble toxins that not easily degraded; therefore, they accumulate in the environment and human body. Several studies have indicated a correlation between POPs metabolic diseases; however, their effects on mitochondria as central organelle cellular metabolism usage of functional markers for disease barely understood. In this study, zebrafish model system was exposed to two subclasses POPs, organochlorine pesticides (OCPs) polychlorinated...

A theoretical model was developed for predicting the flexural load–deflection of simply supported concrete beams internally prestressed with unbonded carbon fibre reinforced polymer (CFRP) tendons under four-point loading. At each state in curve (initial cracking state, initial yielding (if any) and ultimate load state), three equivalent rectangular curvature blocks, which can closely simulate beam rotations at supports midspan deflection, were determined by iteratively correcting strain...

Based on rate constant concept, empirical models were presented for the predictions of age-dependent development compressive and split tensile strengths geopolymer concrete composite (GPCC) with fly ash (FA) blended ground granulated blast furnace slag (GGBFS). The empirically developed based a total 180 cylindrical test results GPCC. Six different independent factors comprising curing temperature, weight ratios GGBFS/binder, aggregate/binder, alkali solution/binder, Na2SiO3/NaOH, NaOH...

Experimental observations were made on eight reinforced concrete wall specimens, with all sides being exposed to an International Organization for Standardization standard heating curve. The main variables thickness, level of axial load, reinforcement ratio, compressive strength and curing period. During the test, temperature increases in wall, time plotted against deformations, measured. effects fire resistance deformation investigated. walls shorter periods high-strength a thin thickness...

The restrained thermal expansion of a pretensioned strand causes prestress loss during steam curing until sufficient bond strength develops. amount is directly related to the characteristics interfacial stress–slip relationship at different maturity phases concrete. For rational assessment, needs be investigated experimentally phases. In this study, total 12 pull-out tests were performed using seven-wire 12.7 mm diameter, concrete equivalent ages 7.8, 23.5, 53.8 and 85.2 h. Based on test...

Early-strength-concrete (ESC) made of Type I cement with a high Blaine value 500 m2/kg reaches approximately 60 % its compressive strength in 1 day at ambient temperature. Based on the 210 test results, generalized rate-constant material model was presented to predict development strengths ESC different equivalent ages (9, 12, 18, 24, 36, 100 and 168 h) maximum temperatures (20, 30, 40, 50 °C) for design 40 MPa. The developed used find optimum curing regimes precast prestressed members ESC....

A versatile strategy to inhibit protein functions in the cytoplasmic environment is eagerly anticipated for drug discovery. In this study, we demonstrate a novel system directly select functional intrabodies from library mammalian cytoplasm. system, target homo-oligomeric antigen expressed together with single-chain Fv (scFv) that linked domain of receptor tyrosine kinase (RTK) cytoplasm murine interleukin-3 (IL-3)-dependent cells. As activated by dimerization, only scFv-RTK clones can bind...

Activating transcription factor 6 (ATF6), one of the three sensor proteins in endoplasmic reticulum (ER), is an important regulator ER stress-induced apoptosis. ATF6 resides and, upon activation, translocated to Golgi apparatus, where it cleaved by site-1 protease (S1P) generate amino-terminal cytoplasmic fragment. Although recent studies have made progress elucidating regulatory mechanisms ATF6, its function during early porcine embryonic development under high-temperature (HT) stress...

High-early-strength concrete (HESC) made of Type III cement attains approximately 60%–70% its design compressive strength at ambient temperature in 1 day. A numerical method incorporating a rate-constant model was developed to optimize curing regimes for HESC preassigned maximum temperatures 40°C, 50°C, and 60°C with strengths 30, 40, 50 MPa. The use after optimization resulted 36%–55% savings terms energy index, compared the regime typically applied I cement. Experimental verification...

During steam curing of concrete, the axial restraint pretensioned strands causes thermal prestress loss accumulated until sufficient bonding occurs. A theoretical model is presented in this paper to predict progressive slippage with time, and amount loss. The incorporating equivalent age-dependent local bond-slip relationships considers effects material-related factors, layout prestressing system, changes temperature. Three pairs two monostrand concrete prisms were fabricated validate...

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Plastics are widely used worldwide due to their convenience. However, microplastics (MPs) accumulation poses a serious threat ecosystem health. Therefore, understanding the effects of MPs on living organisms within native is crucial. Previous studies have primarily focused impacts in aquatic environments, whereas terrestrial ecosystems remained largely understudied. our study assessed soil by characterizing toxic earthworms (Eisenia foetida). Here, we exposed two representative plastics...