A5078944939- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- Salivary Gland Tumors Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sarcoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Head and Neck Anomalies
- Lung Cancer Research Studies
- Viral-associated cancers and disorders
- Cancer Cells and Metastasis
- Soft tissue tumors and treatment
- Cancer, Hypoxia, and Metabolism
- Cervical Cancer and HPV Research
- Genetic factors in colorectal cancer
- Vascular Tumors and Angiosarcomas
- Renal cell carcinoma treatment
- Oral and Maxillofacial Pathology
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Pancreatic and Hepatic Oncology Research
- Lymphoma Diagnosis and Treatment
Changzhi Medical College
2024
Ewha Womans University
2024
Korea University
2009-2024
Korea University Medical Center
2008-2023
Gachon University Gil Medical Center
2013-2022
Gachon University
2012-2020
Sungkyunkwan University
2006-2018
Samsung Medical Center
2006-2018
Rush University Medical Center
2018
Columbia College - Missouri
2018
The aim of this study was to evaluate the prevalence and prognostic role increased gene copy number protein expression MET EGFR in non-small cell lung cancer (NSCLC) patients. Samples were collected from 380 patients with surgically resected NSCLC, fluorescence situ hybridisation (FISH) immunohistochemistry (IHC) performed. amplification high polysomy (EGFR FISH-positive) observed 9.7% 17.4% patients, respectively. overexpressed IHC-positive) 19.2% Neither FISH-positive nor IHC-positive...
Abstract During cancer resection surgeries, intraoperative histopathologic examination of the surgical specimen is crucial for tumor margin identification. A conventional frozen‐section analysis requires complex tissue processing, which prolongs surgery and potentially introduces interpretation errors. Here, as a novel approach to label‐free histopathology, high‐speed reflection‐mode ultraviolet photoacoustic microscopy (UV‐PAM) system employing waterproof 1‐axis microelectromechanical...
Jeong H, Ryu Y‐j, An J, Lee Y & Kim A (2012) Histopathology 60, E87–E95 Epithelial–mesenchymal transition in breast cancer correlates with high histological grade and triple‐negative phenotype Aims: (EMT) is characterized by a loss of epithelial nature the acquisition mesenchymal form. The aim this study was to assess role EMT human mammary carcinogenesis, performing immunohistochemical studies markers tissue microarrays. Methods results: total 492 cases were evaluated classified as...
Heterogeneity in intratumoral cancers leads to discrepancies drug responsiveness, due diverse genomics profiles. Thus, prediction of responsiveness is critical precision medicine. So far, prediction, drugs' molecular "fingerprints", along with mutation statuses, have not been considered. Here, we constructed a 1-dimensional convolution neural network model, DeepIC50, predict three classes, based on 27,756 features including statuses and various fingerprints. As result, DeepIC50 showed better...
Micropapillary carcinoma (MPC) of the stomach is a rare, newly recognized entity, and only 2 patients with this histology have been reported. We investigated clinicopathologic features, expression mucin (MUC2, MUC5AC, MUC6, CD10) cytokeratin profiles (CK7 CK20), epidermal growth factor receptors (EGFR HER2), prognostic markers (p53 Ki-67), outcomes in 11 MPCs stomach. The proportion MPC component ranged from 5% to 70%. features were often found at deep advancing edge tumor. Endolymphatic...
Background:The decrease in incidence of cervical dysplasia and carcinoma has not been as dramatic expected with the development improved research tools test methods.The human papillomavirus (HPV) alone suggested for screening some countries.The National Cancer Screening Project Korea applied Papanicolaou smears (Pap smears) method carcinoma.We evaluated value Pap smear HPV testing diagnostic a single institution.Methods: Patients co-tested simultaneously or within one month each other were...
Gastric cancer (GC), one of the most common cancers worldwide, has a high mortality rate due to limited treatment options. Identifying novel and promising molecular targets is major challenge that must be overcome if advanced GC successful. Here, we used comparative genomic hybridization gene expression microarrays examine genome-wide DNA copy number alterations (CNAs) global in 38 samples from old young patients. We identified frequent CNAs, which included gains on chromosomes 3q, 7p, 8q,...
The aim of this study was to elucidate the predictive risk factors synchronous multiple early gastric cancer regardless treatment modality. Patients who underwent between July 2005 and June 2015 were retrospectively reviewed. In total, 1529 patients treated for included. We analyzed patient's data find compared solitary cancer. Further analysis performed verify difference endoscopic surgical groups. Among patients, diagnosed in 68 (4.4%) patients. Significant differences sex (P = .004),...
The role of heat shock protein 60 (HSP60), a mitochondrial chaperone, in tumor progression or its anti-tumor effects remains controversial. This study aimed to confirm the possibility using HSP60 as prognostic marker patients with colorectal cancer (CRC), considering TNM classification for precise prediction. expression increased differentiation and p53 mutations patients. However, compared high expression, low had event-free survival disease-specific hazard ratios (HRs) 1.42 1.69,...
The incidence of colorectal cancer (CRC) is increasing worldwide. 8-hydroxy-2′-deoxyguanosine (8-OHdG), one the most prevalent DNA alterations, known to be upregulated in several carcinomas; however, 8-OHdG has not been used predict prognosis patients with CRC. We aimed determine levels CRC using immunohistochemistry and conducted a survival analysis according pathological stage. 5-year event-free (EFS) disease-specific (DSS) hazard ratios (HRs) low subgroup were 1.41 (95% confidence...
The purpose of this study was to examine the satisfaction medical students in flipped learning and analyzed academic achievement comparison with lecture class.
Cowden syndrome is a rare autosomal dominant disorder that characterized by multiple hamartomas in variety of tissues and this associated with germline mutations the phosphatase tensin homologue (PTEN) gene, which tumor suppressor gene located on chromosome 10q23.3. It hamartomatous neoplasms skin, oral mucosa, gastrointestinal (GI) tract, bones, central nervous system, eyes, genitourinary tract. does not have increased risk GI malignancy; however, it has an breast, thyroid endometrial...
Basic fibroblast growth factor (bFGF) is a crucial sustaining human pluripotent stem cells (hPSCs). We designed this study to search the substitutive factors other than bFGF for maintenance of hPSCs by using placenta-derived conditioned medium without exogenous (hPCCM−), containing chemokine (C-X-C motif) receptor 2 (CXCR2) ligands, including interleukin (IL)-8 and growth-related oncogene α (GROα), which were developed on basis our previous studies. First, we confirmed that IL-8 and/or GROα...
Stafne bone cavity is a well demarcated defect of the mandible, usually asymptomatic and located in posterior portion bone.1 Most cases have been reported male patients between age 50 70 years.2 This lesion has labeled with various terms, including ectopic salivary gland, idiopathic defect, mandibular gland inclusion, cyst.2 The cavities are often filled normal tissue, but occasional showed contents that included skeletal muscle, fibrous connective tissue adipose tissue.1,2 Bilateral...
Duplications in the alimentary tract are uncommon congenital abnormalities that may occur anywhere from oral cavity to anus, with ileum being most common site.1 Malignant change a duplication is extremely rare. Here, we report case of adenocarcinoma arising colonic cyst 23-year-old female and provide review relevant literature.
Background: Human papillomavirus (HPV) is an oncogenic virus in cervical cancer and most invasive carcinomas (ICs) are caused by HPV16 18.However, the roles contributions of other uncommon rare genotypes remain uncertain.Methods: HPV were retrospectively assessed using DNA chip that can specify up to 32 genotypes.We arbitrarily regarded accounting for less than 6% total as genotypes.Results: A 3,164 HPV-positive cases enrolled.In groups 2A, 2B, 3, unclassified genotypes, 2.4% with (68, 26,...
Primary cardiac cancer is a very rare disease, among which primary angiosarcoma one of the most frequent type and characterized by extremely poor prognosis without established optimal treatment.Here we report case with hemorrhagic pericardial effusion who achieved durable response tumor excision followed concurrent chemoradiotherapy docetaxel. A sixty year old man was presented dyspnea diagnosed effusion. After surgical microscopic residual disease docetaxel, patient showed progression free...
OBJECTIVE To determine the genetic alterations and chemosensitivity profile of collecting duct carcinoma (CDC) kidney, as it is a rare, highly aggressive malignant tumour with frequent distant metastases. MATERIALS AND METHODS We first established characterized two human CDC cell lines designated AP3 AP8, respectively. The were assessed using microarray‐based comparative genomic hybridization testing. RESULTS cells grew in vitro an adherent monolayer epithelial morphology, but had different...
Abstract Gastric cancer is a significant public health concern, emphasizing the need for accurate evaluation of lymphatic invasion (LI) determining prognosis and treatment options. However, this task time‐consuming, labor‐intensive, prone to intra‐ interobserver variability. Furthermore, scarcity annotated data presents challenge, particularly in field digital pathology. Therefore, there demand an objective method detect LI using small dataset, benefiting pathologists. In study, we trained...
Graft-versus-host disease (GVHD) is a rare complication after kidney transplantation.We describe 62-year-old female with end-stage renal due to hypertension.She received 4 mismatched human leukocyte antigen (HLA) out of 6 HLA -A, B, DR from deceased donor.After the procedure, patient showed watery diarrhea on postoperative day (POD) 45.An endoscopic biopsy colon revealed some apoptotic cells consistent GVHD.Thrombocytopenia was gradually developed POD 54.She steroid pulse therapy, and...
Pathologic diagnosis of central nervous system (CNS) neoplasms is made by comparing light microscopic, immunohistochemical, and molecular cytogenetic findings with clinicoradiologic observations. Intraoperative frozen cytology smears can improve the diagnostic accuracy for CNS neoplasms. Here, we evaluate value in diagnoses neoplasms.Cases were selected from patients undergoing both sections. Diagnostic was evaluated.Four hundred fifty-four cases included this retrospective single-center...