A5042723056- Dark Matter and Cosmic Phenomena
- Astrophysics and Cosmic Phenomena
- Helicobacter pylori-related gastroenterology studies
- Particle Detector Development and Performance
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Gastroesophageal reflux and treatments
- Radiation Therapy and Dosimetry
- Inflammatory Bowel Disease
- MicroRNA in disease regulation
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Diverticular Disease and Complications
- Gastrointestinal disorders and treatments
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Screening and Detection
- Atmospheric Ozone and Climate
- Galectins and Cancer Biology
- Neutrino Physics Research
- Cancer, Lipids, and Metabolism
Institute for Basic Science
2025
Seoul National University
2025
Sinai Hospital
2025
Sungkyunkwan University
2012-2024
Gachon University
2012-2024
International St. Mary's Hospital
2016-2023
Catholic Kwandong University
2016-2023
Incheon Medical Center
2019
Government of the Republic of Korea
2019
Pennsylvania State University
2017
Although previous studies have proposed plausible mechanisms of the activation transforming growth factor-β-activated kinase 1 (TAK1) in inflammatory signals, including Toll-like receptors (TLRs), its activating still remains to be unclear. In present study, we provided evidences that AMP-activated protein (AMPK)-α1 has a pivotal role for TAK1, and thereby regulate NF-κB-dependent gene expressions signaling mediated by TLR4 TNF-α stimulation. AMPK-α1 specifically interacts with TAK1...
UDP-GlcNAc serves as a building block for glycosaminoglycan (GAG) chains in cartilage proteoglycans and simultaneously acts substrate O-GlcNAcylation. Here, we show that transporters to the endoplasmic reticulum (ER) Golgi are significantly downregulated osteoarthritic cartilage, leading increased cytosolic O-GlcNAcylation chondrocytes. Mechanistically, upregulated governs senescence-associated secretory phenotype (SASP) by stabilizing GATA4 via at S406, which compromises its degradation...
Abstract Background Elevated antimicrobial antibody levels have been reported up to 6 years before diagnosis of Crohn’s disease (CD), but the specific response is poorly defined. Aims Here, we characterized nature responses CD in healthy first-degree relatives (FDR) patients. Methods The CCC-GEM Project nested case-control cohort consisted FDRs who later developed (n=77), matched 1:4 by age, sex, follow-up duration, and geographical location with remained (n=304). Sera at enrollment were...
Chemoresistance is a leading cause of morbidity and mortality in patients with pancreatic cancer remains an obstacle to successful treatment. The antioxidant transcription factor nuclear (erythroid-derived 2)-related 2 (NRF2), which plays important roles tumor angiogenesis invasiveness, upregulated ductal adenocarcinoma (PDAC), where it correlates poor survival. Here, we investigated the role NRF2 two 5-Fluourouracil-resistant (5-FUR) PDAC cell lines: BxPC-3 CFPAC-1. Levels antioxidants,...
Background/Aims There is increasing need for third-line therapy of Helicobacter pylori due to level antibiotics resistance. The aim this study was compare rifabutin and levofloxacin rescue regimens in patients with first- second-line eradication failures. Methods Patients, whom a first treatment proton pump inhibitor-clarithromycin-amoxicillin second trial inhibitor-bismuth-tetracycline-metronidazole had failed, received either or levofloxacin, plus amoxicillin (1 g twice daily) standard...
Flexible sensors connected to cell phones are a promising technology that can aid in continuously monitoring signals our daily lives, such as an individual's health status and information from buildings, farms, industry. Among signals, real-time humidity is crucial comfortable life, human bodies, plants, industrial environments require appropriate be maintained. We propose hydrophilic polytetrafluoroethylene (H-PTFE)-based flexible sensor integrated with readout circuitry, wireless...
Dissection of Early Gastric CancerAlthough endoscopic submucosal dissection (ESD) is widely accepted as a curative treatment method for early gastric cancer (EGC) worldwide, metachronous recurrence often occurs after ESD EGC.However, there are insufficient data about the role Helicobacter pylori (H.pylori) infection and other risk factors recurrence.We aimed to compare lesion in H. persistent group eradicated group, identify lesion.We retrospectively analyzed 782 patients who underwent...
The aim of this study was to elucidate the predictive risk factors synchronous multiple early gastric cancer regardless treatment modality. Patients who underwent between July 2005 and June 2015 were retrospectively reviewed. In total, 1529 patients treated for included. We analyzed patient's data find compared solitary cancer. Further analysis performed verify difference endoscopic surgical groups. Among patients, diagnosed in 68 (4.4%) patients. Significant differences sex (P = .004),...
Clinicopathologic Similarities of the Main and Minor Lesions Synchronous Multiple Early Gastric CancerThe detection rate early gastric cancer (EGC) is increasing due to improvements in diagnostic methods, but synchronous multiple EGC (SMEGC) remains a major problem.Therefore, we investigated characteristics correlation between main minor lesions SMEGC.We retrospectively reviewed medical records patients with April 2008 May 2013.The lesion was defined as one greatest invasion depth.If had...
The ISS-CREAM instrument is the modified version of Cosmic Ray Energetics And Mass (CREAM) experiment, which was flown on balloons multiple times over Antarctica and later installed International Space Station (ISS). Its primary objective to measure energy spectra individual cosmic-ray elements for charge range Z=1 Z=26, in ∼ 1012 1015 eV. comprises a tungsten/scintillator calorimeter pixelated silicon detector as detectors determine cosmic rays. Additionally, it includes top bottom...
An 80-year-old woman with hilar cholangiocarcinoma was hospitalized due to sudden-onset abdominal pain. Computed tomography revealed hepatic necrosis accompanied emphysematous change in the superior segment of right liver (S7/S8), implying spontaneous rupture, based on presence perihepatic free air. Although urgent percutaneous drainage performed, neither pus nor fluids were drained. These findings suggest hepatitis a mass. Despite application intensive care, patient's condition deteriorated...
(1) Background: Non-alcoholic fatty liver disease (NAFLD) is associated with various cardiometabolic diseases. However, the association between NAFLD and stroke not well known. The purpose of our study to reveal relationship Stroke incidence. (2) Methods: Using data from a Korean prospective cohort study, we excluded participants heavy alcohol consumption history stroke; hence, 7964 adults aged 40–69 years were included in this study. According their index (FLI), divided into three groups:...
Telescope Array (TA) is the largest ultrahigh energy cosmic-ray (UHECR) observatory in Northern Hemisphere. It explores origin of UHECRs by measuring their spectrum, arrival-direction distribution, and mass composition using a surface detector (SD) array covering approximately 700 km2 fluorescence (FD) stations. TA has found evidence for cluster cosmic rays with energies greater than 57 EeV. In order to confirm this more data, it necessary increase data collection rate. We have begun...
Background/Aims: MicroRNAs (miRNAs) regulate gene expression.We assess miRNA regulation by Helicobacter pylori infection and elucidate their role in H. pylori-infected gastric epithelial cells.Methods: The relationship between expression DNA methylation was examined.Cells were treated with the nuclear factor-kappaB (NF-κB) inhibitor Bay 11-7082 to determine NF-κB signal transduction.Results: In negative control cells infected 26695, of six miRNAs increased, whereas five decreased.The...
Background/Aims Periampullary diverticulum (PAD) causes difficulty in the extraction of common bile duct (CBD) stones with conventional endoscopic therapy. Our study was designed to evaluate effect PAD on large balloon dilation (EPLBD) with/without limited sphincterotomy (EST) for CBD stone treatment. Methods We retrospectively reviewed cases 141 patients treated by EPLBD EST at Gachon Gil Medical Center from September 2008 February 2010. were classified into three groups according location...
Abstract Background It is unclear whether obesity increases the incidence of acute pancreatitis (AP) in general population. Further, no study has prospectively examined associations risk AP by etiology with measured body mass index (BMI) values. Methods A total 512 928 Korean participants routine health examinations during 2002–2003 were followed up until 2013 via linkage to national hospital discharge records assess incidence. Multivariable‐adjusted hazard ratios calculated using BMI...
Background/Aims Sustained virologic response (SVR) for the treatment of chronic hepatitis C (CHC) may differ with ethnicity due to differences in genetic traits. This study evaluated efficacy peginterferon and ribavirin, association between IL28B genotypes Korean CHC patients. Methods was a retrospective cohort using data from medical records. Eighty-five patients were eligible assessment antiviral therapy, 47 available an study, which performed Multiplex tetra-primer PCR method rs12979860....
Background: Dysphagia associated with neurologic disorders is a problem worldwide. However, few studies have assessed the efficacy of endoscopic botulinum toxin injections into cricopharyngeal muscle using pharyngoscope.Methods: Fourteen patients who received an injection due to dysfunction and neurological disorder from 2006 2017 were retrospectively reviewed at single tertiary medical center. The was injected 100 international unit (IU) total dose under direct vision. success procedure...
The association between peptic ulcer disease (PUD) and osteoporosis remains unclear. We investigated the PUD by classifying individuals based on gender in a prospective study 10,030 adults Korea at 12-year follow-up examination.The baseline survey of Ansung-Ansan cohort studies was conducted from May 2001 to February 2003, participants (5018 Ansung 5012 Ansan study) completed risk developing higher both men women group than control group.At follow-up, had developed 11.1% (21/189) 29.9%...
Background/Aims: Low-volume preparations for colonoscopy are gaining attention their higher acceptability.However, the efficacy and safety of oral sulfate solution (OSS) in patients with ulcerative colitis (UC) has not been well known.Therefore, we aimed to compare OSS 2-L polyethylene glycol ascorbic acid (PEG+Asc) bowel preparation inactive UC.Methods: A multicenter, randomized, single-blind study was conducted at six tertiary referral hospitals Korea.Outpatients UC who had stable disease...