A5101681542- Liver Disease Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Heat shock proteins research
- Toxin Mechanisms and Immunotoxins
- HER2/EGFR in Cancer Research
- Cancer, Hypoxia, and Metabolism
- Salivary Gland Tumors Diagnosis and Treatment
- Healthcare and Venom Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Acupuncture Treatment Research Studies
- Neuroendocrine Tumor Research Advances
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Liver Diseases and Immunity
- Monoclonal and Polyclonal Antibodies Research
- Breast Cancer Treatment Studies
- Cell Adhesion Molecules Research
- ATP Synthase and ATPases Research
- Stroke Rehabilitation and Recovery
- Botulinum Toxin and Related Neurological Disorders
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
Korea University Medical Center
2022-2024
University Hospital Regensburg
2010-2024
Korea Research Institute of Bioscience and Biotechnology
2018-2024
Korea University
2014-2023
Catholic University of Korea
2008-2021
Daejeon University
2021
Seoul St. Mary's Hospital
2016
University of Regensburg
2008-2012
Sungkyunkwan University
2012
Samsung (South Korea)
2012
Chemotherapy typically destroys the tumor mass but rarely eradicates cancer stem cells (CSCs) that can drive metastatic recurrence. A key current challenge is finding ways to eradicate CSCs and suppress their characteristics. Here, we report a prodrug, Nic-A, created by combining carbonic anhydrase IX (CAIX) inhibitor, acetazolamide, with signal transducer transcriptional activator 3 (STAT3) niclosamide. Nic-A was designed target triple-negative breast (TNBC) found inhibit both proliferating...
Rationale: Resistance to targeted therapies like trastuzumab remains a critical challenge for HER2-positive breast cancer patients.Despite the progress of several N-terminal HSP90 inhibitors in clinical trials, none have achieved approval use, primarily due issues such as induction heat shock response (HSR), off-target effects, and unfavorable toxicity profiles.We sought examine effects HVH-2930, novel C-terminal inhibitor, overcoming resistance.Methods: The effect HVH-2930 on...
Although previous studies have proposed plausible mechanisms of the activation transforming growth factor-β-activated kinase 1 (TAK1) in inflammatory signals, including Toll-like receptors (TLRs), its activating still remains to be unclear. In present study, we provided evidences that AMP-activated protein (AMPK)-α1 has a pivotal role for TAK1, and thereby regulate NF-κB-dependent gene expressions signaling mediated by TLR4 TNF-α stimulation. AMPK-α1 specifically interacts with TAK1...
Abstract Aims/hypothesis Non-alcoholic fatty liver disease (NAFLD) associated with type 2 diabetes may more easily progress towards severe forms of non-alcoholic steatohepatitis (NASH) and cirrhosis. Although the Wnt effector transcription factor 7-like (TCF7L2) is closely risk, role TCF7L2 in NAFLD development remains unclear. Here, we investigated how changes expression affects hepatic lipid metabolism based on major risk factors development. Methods Tcf7l2 was selectively ablated C57BL/6N...
Research Articles| February 16 2011 Split Sample Comparison of a Liquid-Based Method and Conventional Smears in Thyroid Fine Needle Aspiration Subject Area: Pathology Cell Biology Chan-Kwon Jung; Jung From the Department Hospital Radiology, College Medicine, The Catholic University Korea, Seoul, Republic Korea. Search for other works by this author on: This Site PubMed Google Scholar Ahwon Lee; Lee Eun-Sun Yeong-Jin Choi; Choi So-Lyung Kyo-Young Acta Cytologica (2008) 52 (3): 313–319....
BRAF mutation is the most common genetic event in papillary thyroid carcinoma (PTC); however, prevalence and patterns of vary worldwide. We investigated frequency type mutations based on histologic subtypes a large cohort Korean patients with PTC.A total 1041 consecutive PTCs were classified according to subtypes. examined by denaturing high-performance liquid chromatography direct sequencing. Rare complex confirmed molecular cloning polymerase chain reaction amplicons sequencing...
A predictive biomarker of immune checkpoint inhibitor (ICI)-based treatments in hepatocellular carcinoma (HCC) has not been clearly demonstrated. In this study, we focused on the infiltration and programmed death ligand 1 (PD-L1) expression tumor-associated macrophages (TAMs) tumor microenvironment HCC. Immunohistochemistry demonstrated that PD-L1 was preferentially expressed CD68+ HCC, suggestive its TAMs rather than T cells or (P < 0.05). co-culture experiment using activated M2...
Abstract Despite recent advances, there remains a significant unmet need for the development of new targeted therapies triple-negative breast cancer (TNBC). Although heat shock protein HSP90 is promising target, previous inhibitors have had issues during including undesirable induction response (HSR) and off-target effects leading to toxicity. SL-145 novel, rationally-designed C-terminal inhibitor that induces apoptosis in TNBC cells via suppression oncogenic AKT, MEK/ERK, JAK2/STAT3...
Increasing evidence has demonstrated that increased expression of cyclin-dependent kinase regulatory subunit 1B (CKS1B) is associated with the pathogenesis many human cancers, including colorectal cancer (CRC). However, mechanisms underlying CKS1B in CRC are not completely understood. Here, we investigate role played by microRNAs and carcinogenesis CRC. Among six predicted to target gene expression, only miR-1258 was revealed downregulate through binding its 3’-UTR region, as ectopic...
Abstract Background Triple-negative breast cancer (TNBC) is characterized by aggressive growth and a high propensity for recurrence metastasis. Simultaneous overexpression of c-MET EGFR in TNBC associated with worse clinicopathological features unfavorable outcomes. Although the development new inhibitors emergence 3 rd -generation represent promising treatment options, costs involved limit accessibility these drugs. In present study, we sought to investigate therapeutic potential doxazosin...
The emergence of de novo or intrinsic trastuzumab resistance is exceedingly high in breast cancer that HER2 positive and correlates with an abundant stem cell (CSC)-like population. We sought to examine the capacity β-escin, anti-inflammatory drug, address HER2-positive cells.The effect β-escin on trastuzumab-resistant -sensitive lines vitro was evaluated for apoptosis, expression family members, impact CSC-like properties. An vivo model JIMT-1 used efficacy toxicity β-escin.β-escin induced...
Purpose: In this study we investigated the sensitivity of high resolution ultrasound (HRU) in detection small liver tumors and its microcirculation a humanized tumor mouse model (HTM). These mice develop complete human immune system h
Neuroendocrine tumors (NETs) are mostly found in the gastrointestinal tract and pancreas. The World Health Organization (WHO) classification (2010) has been widely used to categorize NETs [1]. In digestive system, including those within bile ducts, classed as NET G1 (carcinoid, mitotic count of 20 per 10 HPF and/or >20% Ki-67 index), mixed adenoneuroendocrine carcinoma (MANEC) arising from duct rare, accounting for only 1.8% gastroenteropancreatic [2]. MANECs common ducts (CBDs) extremely a...
We sought to investigate the utility of ebastine (EBA), a second-generation antihistamine with potent anti-metastatic properties, in context breast cancer stem cell (BCSC)-suppression triple-negative (TNBC). EBA binds tyrosine kinase domain focal adhesion (FAK), blocking phosphorylation at Y397 and Y576/577 residues. FAK-mediated JAK2/STAT3 MEK/ERK signaling was attenuated after challenge vitro vivo. treatment induced apoptosis sharp decline expression BCSC markers ALDH1, CD44 CD49f,...
Ziel: Bestimmung des technischen und klinischen Erfolges der perkutanen Stentangioplastie zur Therapie chronischen mesenterialen Ischämie (CMI). Patienten Methoden: Eingeschlossen wurden 17 (12w, 5m, Durchschnittsalter 67 Jahre), die aufgrund ihrer Symptomatik bei CMI mit einer splanchnischen Arterien (Truncus coeliacus, TC; Arteria mesenterica superior, AMS; inferior, AMI) versorgt wurden. Bestimmt primäre bzw. sekundäre technische Erfolg, darüber hinaus klinische Erfolg sowie...