A5050464024- Cancer Cells and Metastasis
- Helicobacter pylori-related gastroenterology studies
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Circular RNAs in diseases
- Histone Deacetylase Inhibitors Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced biosensing and bioanalysis techniques
- TGF-β signaling in diseases
- Endoplasmic Reticulum Stress and Disease
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Biochemical and Molecular Research
- Protein Degradation and Inhibitors
- Ferroptosis and cancer prognosis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Thyroid Disorders and Treatments
- Extracellular vesicles in disease
- Peptidase Inhibition and Analysis
- Autophagy in Disease and Therapy
Korea Research Institute of Bioscience and Biotechnology
2018-2024
Korea University of Science and Technology
2022-2024
Sungkyunkwan University
2023-2024
Kanazawa University
2014-2021
Seoul National University
2012-2015
Kaohsiung Veterans General Hospital
1993
We report an unusual case in which physiologic neck rotation impeded perfusion through the internal carotid artery. The patient had a history of prior radical surgery and radiation for malignancy. He presented withbow hunter's-like symptoms with transient loss consciousness right-sided weakness left lateral rotation. A self-expanding peripheral stent was successfully used to treat by preventing rotatory compression. In select patients radiation, injections should be part dynamic cerebral...
The human microbiome plays an essential role in the immune system, food digestion, and protection from harmful bacteria by colonizing intestine. Recently, although affects colorectal cancer (CRC) treatment, mode of action between CRC remains unclear. This study showed that propionate suppressed growth promoting proteasomal degradation euchromatic histone-lysine N-methyltransferase 2 (EHMT2) through HECT domain E3 ubiquitin protein ligase (HECTD2) upregulation. In addition, EHMT2...
Arachidonic and adrenic acids in the membrane play key roles ferroptosis. Here, we reveal that lipoprotein-associated phospholipase A2 (Lp-PLA2) controls intracellular phospholipid metabolism contributes to ferroptosis resistance. A metabolic drug screen reveals darapladib, an inhibitor of Lp-PLA2, synergistically induces presence GPX4 inhibitors. We show darapladib is able enhance under lipoprotein-deficient or serum-free conditions. Furthermore, find Lp-PLA2 located cytoplasm suppresses...
Silica nanoparticles (SiNPs) are widely used for biosensing and diagnostics, the targeted delivery of therapeutic agents. Safety concerns about biomedical clinical applications SiNPs have been raised, necessitating analysis effects their intrinsic properties, such as sizes, shapes, surface physicochemical characteristics, on human health to minimize risk in applications. In particular, SiNP size-associated toxicological effects, underlying molecular mechanisms vascular endothelium remain...
Directed differentiation of hPSCs and transition from 3D intestinal organoids into functional hIECs.
Abstract Epigenetic alterations, especially histone methylation, are key factors in cell migration and invasion cancer metastasis. However, lung metastasis, the mechanism by which methylation regulates metastasis has not been fully elucidated. Here, we found that methyltransferase SMYD2 is overexpressed knockdown of could reduce rates lines via direct downregulation SMAD3 SMYD2-mediated epigenetic regulation. Furthermore, using an vitro epithelial-mesenchymal transition (EMT) system with a...
Abstract Gastric cancer (GC) is the fourth most common worldwide. In spite of mortality incidence associated with GC, no reliable prognostic biomarkers are currently available for this malignancy. The sulfatases (or SULFs), SULF1 and SULF2, play a critical role in pathogenesis variety human cancers. We sought to evaluate potential SULFs as GC. Thirty pairs GC corresponding normal tissues were analysed expression methylation status . Furthermore, functional SULF overexpression was...
Microsatellite instability (MSI) is a critical mechanism that drives genetic aberrations in cancer. To identify the entire MS mutation, we performed first comprehensive genome- and transcriptome-wide analyses of mutations associated with MSI Korean gastric cancer cell lines primary tissues. We identified 18,377 five or more repeat nucleotides coding sequences untranslated regions genes, discovered 139 individual genes whose expression was down-regulated association UTR mutation. In addition,...
Lactobacilli, which are probiotic commensal bacteria that mainly reside in the human small intestine, have attracted attention for their ability to exert health-promoting effects and beneficially modulate host immunity. However, epithelial-commensal bacterial interactions still largely unexplored because of limited access intestinal tissues. Recently, we described an vitro maturation technique generating adult-like, mature organoids (hIOs) from pluripotent stem cells (hPSCs) closely resemble...
Abstract Aims/hypothesis Non-alcoholic fatty liver disease (NAFLD) associated with type 2 diabetes may more easily progress towards severe forms of non-alcoholic steatohepatitis (NASH) and cirrhosis. Although the Wnt effector transcription factor 7-like (TCF7L2) is closely risk, role TCF7L2 in NAFLD development remains unclear. Here, we investigated how changes expression affects hepatic lipid metabolism based on major risk factors development. Methods Tcf7l2 was selectively ablated C57BL/6N...
Purpose The purpose of this study is to investigate differentially expressed genes using DNA microarray between advanced gastric cancer (AGC) with aggressive lymph node (LN) metastasis and that a more tumor stage but without LN metastasis. Materials Methods Five sample pairs tissue normal mucosa were taken from three patients T3N3 (highN) two T4N0 (lowN). Data triplicate experiments analyzed, candidate identified volcano plot showed ≥ 2-fold differential expression significant by Welch's t...
Increasing evidence has demonstrated that increased expression of cyclin-dependent kinase regulatory subunit 1B (CKS1B) is associated with the pathogenesis many human cancers, including colorectal cancer (CRC). However, mechanisms underlying CKS1B in CRC are not completely understood. Here, we investigate role played by microRNAs and carcinogenesis CRC. Among six predicted to target gene expression, only miR-1258 was revealed downregulate through binding its 3’-UTR region, as ectopic...
MicroRNAs (miRNAs) are important diagnostic and prognostic biomarkers for various tumors. Currently, many systems have been developed to detect miRNAs, but simple techniques detecting miRNAs still required. Recently, we reported that the expression of miRNA-135b is upregulated in gastric epithelial cells during inflammation carcinogenesis. Our aim was develop an vitro platform analyze cancer-related blood. The comprised isothermal amplification-based lateral flow biosensor (IA-LFB) enables...
MicroRNAs (miRNAs) circulating in body fluid have emerged as potential biomarkers for various diseases; however, owing to their low concentrations and short lengths (∼22 nt), clinical applications are still limited. Therefore, a highly sensitive selective novel diagnostic platform miRNA detection is required. Here, we present hydrogel-based fuel stimulant-powered (FSP) amplification of fluorescent signals detect miRNAs from samples human serum. The advantage this method that it has high...
Owing to their unique properties and biological activities, ionic liquids (ILs) have attracted research interest in pharmaceutics medicine. Hypoxia-inducible factor (HIF)- 1α is an attractive cancer drug target involved malignancy the hypoxic tumor microenvironment. Herein, we report inhibitory activity of ILs on HIF-1α pathway mechanism action. Substitution a dimethylamino group pyridinium reduced hypoxia-induced activation. It selectively inhibited viability human colon cell line HCT116,...
Endothelin receptor A (EDNRA) has been reported to play various crucial physiological roles and shown be associated with the pathology of several diseases, including colorectal cancer (CRC). However, molecular mechanisms EDNRA in development human CRC have not fully elucidated date. In this context, present study was performed investigate biological functions novel downstream signaling pathways affected by EDNRA, during progression. First, using public data repositories, it observed that...
The nuclear factor-κB (NF-κB) signalling pathway plays a critical role in the pathogenesis of multiple vascular diseases. However, endothelial cells (ECs), molecular mechanisms responsible for negative regulation NF-κB are poorly understood. In this study, we investigated novel protein tyrosine phosphatase type IVA1 (PTP4A1) ECs.In human tissues, umbilical artery ECs, and mouse models loss function gain PTP4A1, conducted histological analysis, immunostaining, laser-captured microdissection...
Abstract Gallbladder carcinoma (GBC) exhibits poor prognosis due to local recurrence, metastasis, and resistance targeted therapies. Using clinicopathological analyses of GBC patients along with molecular in vitro tumor vivo analysis cells, we showed that reduction Dsg2 expression was highly associated higher T stage, more perineural, lymphatic invasion. Dsg2-depleted cells exhibited significantly enhanced proliferation, migration, invasiveness growth metastasis through Src-mediated...