A5002354629- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Liver Disease and Transplantation
- Nutritional Studies and Diet
- Nutrition, Health and Food Behavior
- Cancer, Hypoxia, and Metabolism
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metabolism, Diabetes, and Cancer
- Hair Growth and Disorders
- Pancreatitis Pathology and Treatment
- Immune Cell Function and Interaction
- Speech and Audio Processing
- Pancreatic function and diabetes
- Obesity, Physical Activity, Diet
- Spectroscopy and Chemometric Analyses
- Speech Recognition and Synthesis
- Liver Diseases and Immunity
- Phytoestrogen effects and research
- Immune cells in cancer
- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- Olfactory and Sensory Function Studies
Yonsei University
2020-2024
Seoul National University
2007-2024
Korea Food Research Institute
2023-2024
Seoul National University Hospital
2012-2024
Bayer (France)
2024
Novo Nordisk (United Kingdom)
2024
Green Cross (South Korea)
2024
Bayer (United States)
2024
Eisai (Japan)
2024
Daewoong Pharmaceutical (South Korea)
2024
No medication has been found to reduce liver-related events. We evaluated the effect of sodium-glucose cotransporter-2 inhibitor (SGLT2i) on outcomes.
Abstract Background and Aims Metabolic dysfunction‐associated fatty liver disease (MAFLD) encompasses heterogeneous diseases associated with metabolic disorders. We aimed to evaluate the association between MAFLD extrahepatic malignancies based on subtypes. Methods This nationwide cohort study included 9 298 497 patients who participated in a health‐screening programme of National Health Insurance Service Korea 2009. Patients were further classified into four subgroups: non‐MAFLD, diabetes...
Summary Background Proton pump inhibitors (PPI) are frequently used in patients with cirrhosis. Aims This study aimed to determine whether PPI use is associated the prognosis of cirrhotic patients. Methods We conducted a multicentre retrospective cohort involving 1485 who had experienced hepatic encephalopathy (HE) from 7 referral centres Korea. The primary outcome was overall survival and secondary outcomes included development complications, including recurrent HE, spontaneous bacterial...
Abstract Background/aim In a randomized controlled trial, lenvatinib was non-inferior to sorafenib in overall survival (OS) of patients with unresectable hepatocellular carcinoma (uHCC). This study aimed compare the effects and as first-line systemic therapy against uHCC real-world data chronic hepatitis B patients. Methods retrospective single-center involved 132 HBV-related uHCC. Propensity score matching (PSM) used balance baseline characteristics, including age, sex, serum...
<h3>Importance</h3> Retinoids are bioactive forms of vitamin A that essential in the maintenance epithelial maturation and differentiation. Synthetic retinoids used chemoprevention skin cancer among high-risk populations with potential adverse effects. Epidemiologic data on intake risk cutaneous squamous cell carcinoma (SCC) limited. <h3>Objective</h3> To examine whether is associated a reduction SCC risk. <h3>Design, Settings, Participants</h3> This cohort study prospectively examined...
Olfactory receptors are ectopically expressed in extra-nasal tissues. The gut is constantly exposed to high levels of odorants where ectopic olfactory may play critical roles. Activation receptor 544 (Olfr544) by azelaic acid (AzA), an Olfr544 ligand, reduces adiposity mice fed a high-fat diet (HFD) regulating fuel preference fats. Herein, we investigated the novel function gut. In GLUTag cells, AzA induces cAMP-PKA-CREB signaling axis and increases secretion GLP-1, enteroendocrine hormone...
Hypoxia inducible factor (HIF)-1α is an important transcription regulating cancer metabolism in hypoxic environment. Capsaicin known to inhibit hypoxia-induced HIF activity lung cancer. Hence, this study we tried elucidate its inhibitory mechanism of action. In cells, including H1299, H23, A549, and H2009 capsaicin inhibited cell growth activation. Under conditions, reduced the accumulation HIF-1α protein expression target genes, pyruvate dehydrogenase kinase 1 (PDK1) glucose transporter...
Background/Aim: Atezolizumab plus bevacizumab and lenvatinib are currently available as first-line therapy for the treatment of unresectable hepatocellular carcinoma (HCC). However, comparative efficacy studies still limited. This study aimed to investigate effectiveness these treatments in HCC patients with portal vein tumor thrombosis (PVTT).Methods: We retrospectively included who received either atezolizumab or systemic PVTT. Primary endpoint was overall survival (OS), secondary...
Tenofovir disoproxil fumarate (TDF) is reportedly superior or at least comparable to entecavir (ETV) for the prevention of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B; however, it has distinct long-term renal and bone toxicities. This study aimed develop validate a machine learning model (designated as Prediction Liver cancer using Artificial intelligence-driven Network-antiviral Selection B [PLAN-S]) predict an individualized risk HCC during ETV TDF therapy.This...
Background US is a standard surveillance tool of hepatocellular carcinoma (HCC), but its effectiveness varies depending on the degree fibrosis or steatosis and etiologies liver disease. Purpose To evaluate detection power occurrence HCC according to Liver Imaging Reporting Data System (LI-RADS) visualization score in chronic hepatitis B (CHB). Materials Methods Consecutive patients with CHB undergoing regular at tertiary referral hospital were retrospectively included this study. During...
Hypoxia-inducible factor (HIF)-1 is an important regulator of the cellular response in hypoxic tumor environment. While searching for HIF inhibitors derived from natural products that act as anticancer agents, we found Glycyrrhiza uralensis exerts HIF-1 inhibitory activity cancer cells. Among five components G. uralensis, licochalcone A was to potently suppress hypoxia-induced HIF-1α accumulation and expression target genes, including GLUT1 PDK1 HCT116 Licochalcone also enhances...
Abstract Background Korea is expected to become a super-aged society in 2026, and improving nutritional status, which directly related health problems, therefore important for increasing healthy life expectancy. Frailty the most complex phenotype of aging, leads adverse outcomes, disability, poor quality life, hospitalization, mortality. Malnutrition major risk factor frailty syndrome. This study aimed investigate incidence pre-frailty or second wave (T2, 2018–2019) according general...
Abstract Background: Fat intake has been associated with certain cancers, including colorectal, breast, and prostate cancers. However, literature on dietary fat skin cancer limited. Methods: We examined the association between risk of cutaneous malignant melanoma, squamous cell carcinoma (SCC), basal (BCC) within two prospective studies: Nurses’ Health Study (NHS) Professionals Follow-up (HPFS). Dietary information total, saturated, monounsaturated, polyunsaturated, omega-6, omega-3...
Abstract The group II metabotropic glutamate 2/3 (mGlu ) receptor antagonist LY341495 produces antidepressant-like effects by acting on mammalian target of rapamycin complex 1 (mTORC1) signaling and α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors in rodent. We investigated whether affects neuroplasticity via these mechanisms rat primary hippocampal cultures under conditions dexamethasone (DEX)-induced neurotoxicity. Ketamine was used for comparison. Hippocampal were treated...
The surgical treatment for large hepatocellular carcinoma (HCC) remains controversial due to a high risk of recurrence after resection. This study aimed compare long-term outcomes transarterial radioembolization (TARE) with resection patients HCC. <b>Methods:</b> retrospective cohort included total 557 who were initially treated either (the group, <i>n</i> = 500) or TARE 57) (≥5 cm) single nodular HCC at two tertiary centers in Korea. Patients major portal vein tumor thrombosis extrahepatic...
Introduction Favorable responses to the treatment including immune checkpoint inhibitors (ICIs) have been consistently reported in lung cancer with smoking history. As tumor microenvironment (TME) may be involved response ICIs, we aimed investigate TME of different status. Methods Lung adenocarcinoma (LUAD) tissue (Tu) and adjacent normal-appearing (NL) from current never smokers were investigated by single-cell RNA sequencing immunofluorescence immunohistochemical staining. The clinical...
Exacerbations of chronic obstructive pulmonary disease (COPD) lead to high morbidity and mortality. Respiratory virus infection is considered as one the important causes COPD exacerbations. The aim this study was assess prevalence respiratory in exacerbations find factors associated with susceptibility viral infections. Furthermore, we tried examine if caused by infections have more severe clinical outcomes comparison those non-viral causes. We enrolled patients acute who were hospitalized a...
Chronic hepatitis B (CHB) is related to an increased risk of extrahepatic malignancy (EHM), and antiviral treatment associated with incidence EHM comparable controls. We compared the risks intrahepatic (IHM) between entecavir (ETV) tenofovir disoproxil fumarate (TDF) treatment. Using data from National Health Insurance Service Korea, this nationwide cohort study included treatment-naïve CHB patients who initiated ETV (n=24,287) or TDF (n=29,199) therapy 2012 2014. The primary outcome was...