A5007720686- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Gastric Cancer Management and Outcomes
- Pharmacological Effects of Natural Compounds
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Cells and Metastasis
- Healthcare and Venom Research
- Colorectal Cancer Screening and Detection
- Lung Cancer Treatments and Mutations
- Appendicitis Diagnosis and Management
- Hepatitis Viruses Studies and Epidemiology
- Liver Diseases and Immunity
- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Drug-Induced Hepatotoxicity and Protection
- Cardiovascular Disease and Adiposity
- Metastasis and carcinoma case studies
- Bioinformatics and Genomic Networks
Seoul Metropolitan Government
2014-2024
Seoul National University
2015-2024
Boramae Medical Center
2015-2024
Samsung (South Korea)
2023-2024
New Generation University College
2023
Seoul National University Hospital
2006-2017
American Society of Clinical Oncology
2016
University of California Davis Medical Center
2014-2015
Sungkyunkwan University
2011
Samsung Medical Center
2008-2011
Abstract MicroRNAs (miRNAs) regulate post‐transcriptional gene expression in various physiological and pathological processes, including viral infections. The miR‐17‐92 cluster encodes six miRNAs (miR‐17‐5p, miR‐18a, miR‐19a, miR‐19b, miR‐20a, miR‐92a‐1) which are transactivated by c‐Myc. Because hepatitis B virus transactivates c‐Myc, the interaction between HBV replication was examined this study. Inducing a human hepatoma cell line increased miR‐17‐5p, miR‐20a miR‐92a‐1 expression....
The aims of this study were to investigate whether acid suppressive therapy increases the risk spontaneous bacterial peritonitis (SBP) and define factors associated with mortality in cirrhotic patients SBP.Cirrhotic who had undergone paracentesis after hospitalization included. Those divided into two groups according presence or absence SBP. Factors development SBP analyzed. Mortality rates during within 30 days also analyzed.A total 1140 (median age, 62; men, 75%; model for end-stage liver...
The diagnostic performance of supersonic shear imaging (SSI) in comparison with those transient elastography (TE) and acoustic radiation force impulse (ARFI) for staging fibrosis nonalcoholic fatty liver disease (NAFLD) patients has not been fully assessed, especially Asian populations relatively lean NAFLD compared to white populations. Thus, we focused on comparing the performances TE, ARFI, SSI a head-to-head manner, identifying clinical, anthropometric, biochemical, histological features...
Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of heterogeneous metabolic subtypes. This study compared the diagnostic performances noninvasive fibrosis tests in predicting advanced among patients with NAFLD and examined effects subgroups on their performances.Three hundred fifteen biopsy-proven were prospectively enrolled. Acoustic radiation force impulse imaging (ARFI) was performed to obtain stiffness measurements (LSMs). The aspartate aminotransferase-to-alanine...
Esophageal varix and its hemorrhage are serious complications of liver cirrhosis. Recent studies have focused on noninvasive prediction esophageal varices. We attempted to evaluate the association spleen stiffness (LS SS) as measured by acoustic radiation force impulse imaging, with presence severity varices variceal in cirrhotic patients. LS SS, along endoscopic examination for a total 125 patients at single referral hospital this prospective observational study. The diagnostic utility...
Background SK Hep-1 cells (SK cells) derived from a patient with liver adenocarcinoma have been considered human hepatoma cell line mesenchymal origin characteristics, however, do not express genes and exhibit function, thus, we hypothesized whether might contribute to primary cancers. Here, characterized its tumourigenicity. Methods Principal Findings We found that classical stem (MSC) markers were presented on cells, but endothelial marker CD31, hematopoietic CD34 CD45 negative. are...
To investigate the clinical characteristics of adverse events (AEs) after COVID-19 vaccination in patients South Korea.Data from Korean Disease Control and Prevention Agency on AEs 4 vaccines, including AZD1222, BNT162b2, JNJ-78436735, mRNA-1273, February 26, 2021, to August 21, were assessed. The epidemiological characteristics, symptoms, severity, complications, mortality descriptively analyzed.Overall, 36.3 million individuals who completed doses during study period included, 153,183...
PatientsWe retrospectively analyzed medical records of the patients who underwent EMR gastric polyps from April 1996 to February 2003 at Seoul Municipal Boramae Hospital.
To investigate the usefulness of tumor markers and adenosine deaminase in differentiating between tuberculous peritonitis (TBP) peritoneal carcinomatosis (PC).A retrospective analysis data was performed on consecutive patients who underwent peritoneoscopic abdominal computed tomography (CT) evaluations. Among 75 at Seoul National University Hospital from January 2000 to June 2010 both tests, 27 (36.0%) 25 (33.3%) were diagnosed with TBP PC, respectively. Diagnosis confirmed by biopsy.Serum...
To investigate the role of sleep quality and psychosocial problems as predictors functional gastrointestinal disorders (FGIDs) in doctors that work 24 hour-on-call shifts.In this cross-sectional observation study, using Rome III Questionnaire Pittsburgh Sleep Quality Index (PSQI), we analyzed 170 with shifts.Among participants had experienced a shift within last 6 mo, 48 (28.2%) FGIDs. Overall prevalence irritable bowel syndrome (IBS) dyspepsia (FD) were 16.5% 17.1%, respectively, 5.3%...
Abstract Background & Aims Nonalcoholic fatty liver disease (NAFLD) is known to increase the risk of adenomatous colonic polyps. However, role screening colonoscopy in patients with biopsy‐proven NAFLD detecting advanced colorectal neoplasm not clearly evidence‐based. Therefore, we investigated whether histological severity associated neoplasm. Methods This study included ≥18 years old who underwent between 2013 and 2018 within a biopsy‐evaluated prospective cohort. Advanced was defined...
Non-alcoholic fatty liver disease (NAFLD) affects obese and non-obese individuals. However, mechanisms underlying non-alcoholic steatohepatitis (NASH) remain unclear.To attempt to identify metabolic perturbations associated with NAFLD using a lipidomics approach.A cross-sectional analysis of 361 subjects biopsy-proven (157 NAFL 138 NASH) healthy controls (n = 66) was performed. Individuals were categorised as or based on the Asian cut-off for body mass index. Circulating lipidomic profiling...
Alcoholic liver diseases often evolve to acute-on-chronic failure (ACLF), which increases the risk of (multi-)organ and death. We investigated development characteristics alcohol-related ACLF evaluated prognostic scores for prediction mortality in Asian patients with active alcoholism.A total 205 who were hospitalized severe alcoholic disease included this retrospective cohort study, after excluding those serious cardiovascular diseases, malignancy, or co-existing viral hepatitis. The...
This study compared the clinical outcomes between endoscopic and radiologic placement of self-expandable metal stent (SEMS) in patients with malignant colorectal obstruction.In total, 111 were retrospectively enrolled this January 2003 June 2011 at Seoul National University Boramae Hospital. Technical success rates, complication patency using an (n=73) or (n=38) method during SEMS procedure.The technical rate was higher than (100% [73/73] vs. 92.1% [35/38], respectively; p=0.038). In...
Background/Aims Carnitine and vitamin complex (Godex®) is widely used in patients with chronic liver disease who show elevated enzyme South Korea. The purpose of this study to identify the efficacy safety carnitine from entecavir combination therapy Alanine aminotransferase (ALT) Chronic Hepatitis B (CHB) patients. Methods 130 treatment-naïve CHB were enrolled 13 sites. randomly selected carnitine. primary endpoint ALT normalization level after 12 months. Results Among patients, 119...
A large number of cancer stem cells (CSCs) were identified and characterized; however, the origins formation CSCs remain elusive. In this study, we examined origination newly CD34(+) liver CSC (LCSC). We found that LCSC coexpressed cell myelomonocytic markers, showing a mixed phenotype, combination hepatobiliary stem/progenitor (HSPCs) cells. Moreover, human xenografts produced by LCSCs parental cells, which was isolated from, also demonstrating phenotypes. The secreted albumin their...
Oxaliplatin-based regimens are standard treatments for the patients with colorectal cancer (CRC) and advanced gastric (AGC). However, owing to hepatic sinusoidal obstruction syndrome (SOS), use of oxaliplatin sometimes results in splenomegaly. The aim present study was evaluate correlation between chemotherapy-associated changes noninvasive liver fibrosis indices volumetric spleen.From February 2004 April 2014, CRC or AGC receiving oxaliplatin-based chemotherapy were studied. possibility SOS...
Summary Nucleos(t)ide analogues ( NA s) have been shown to decrease the risk of hepatocellular carcinoma HCC ) recurrence. This study evaluated whether high‐potency s (entecavir and tenofovir disoproxil fumarate [ TDF ]) reduce tumour recurrence more potently than low‐potency after curative treatment hepatitis B virus HBV )‐related . included 607 consecutive ‐related patients treated with surgical resection or radiofrequency ablation. The were categorized into three groups according...
Abstract Background and Aims Bile acid (BA) dysregulation is related to not only metabolic diseases but also nonalcoholic fatty liver disease (NAFLD). We investigated whether circulating BA levels are altered according the histological severity of NAFLD independent derangements. Methods Global profiling targeted analysis using sera collected from biopsy‐proven no‐NAFLD (n = 67), (NAFL) 99), steatohepatitis (NASH, n 75) subjects were performed sequentially. Circulating metabolome integrated...
Chronic hepatitis B (CHB) is related to an increased risk of extrahepatic malignancy (EHM), and antiviral treatment associated with incidence EHM comparable controls. We compared the risks intrahepatic (IHM) between entecavir (ETV) tenofovir disoproxil fumarate (TDF) treatment. Using data from National Health Insurance Service Korea, this nationwide cohort study included treatment-naïve CHB patients who initiated ETV (n=24,287) or TDF (n=29,199) therapy 2012 2014. The primary outcome was...