A5008732306- Inflammatory Bowel Disease
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Colorectal Cancer Surgical Treatments
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- NF-κB Signaling Pathways
- Gastrointestinal motility and disorders
- Immune Cell Function and Interaction
- Diverticular Disease and Complications
- Immune Response and Inflammation
- Eosinophilic Esophagitis
- Viral gastroenteritis research and epidemiology
- Mycobacterium research and diagnosis
- Gastrointestinal disorders and treatments
- Nutrition and Health in Aging
- Liver Disease and Transplantation
- Gastroesophageal reflux and treatments
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal Tumor Research and Treatment
- IL-33, ST2, and ILC Pathways
Seoul National University
2016-2025
New Generation University College
2011-2024
Seoul National University Hospital
2015-2024
California Liver Research Institute
2023
Boramae Medical Center
2013-2022
Seoul Metropolitan Government
2018-2021
Tokai University Hospital
1985
Tokai University
1984
The aim of this study is to evaluate the effect metformin on intestinal inflammation.COLO205 cells were pretreated with and stimulated tumor necrosis factor (TNF)-α. Expression interleukin (IL)-8 was determined by luciferase assay real-time PCR. Inhibitor kappaB (IκB) phosphorylation/degradation adenosine monohosphate-activated protein kinase (AMPK) activity evaluated Western blotting. DNA-binding transcription nuclear factor-kappaB (NF-κB) assessed electrophoretic mobility shift assay. In...
Abstract Background Helicobacter pylori causes chronic gastritis, gastroduodenal ulcers, and gastric cancer, has been treated with two antibiotics (amoxicillin clarithromycin) proton‐pump inhibitors ( PPI s). However, antibiotic treatment alters the indigenous gut microbiota to cause side effects. Therefore, effects of probiotic supplementation on therapy have studied. Although several studies covered probiotics’ effects, details about changes after H. eradication not evaluated. we analyzed...
Although fluoxetine, a selective serotonin reuptake inhibitor, is known to demonstrate anti-inflammatory activity, little information available on the effect of fluoxetine regarding intestinal inflammation. This study investigates role in attenuation acute murine colitis by suppression NF-κB pathway epithelial cells (IEC). Fluoxetine significantly inhibited activated signals and upregulated expression interleukin-8 (IL-8) COLO 205 colon stimulated with tumor necrosis factor-α (TNF-α)....
The aims of this study were to investigate whether acid suppressive therapy increases the risk spontaneous bacterial peritonitis (SBP) and define factors associated with mortality in cirrhotic patients SBP.Cirrhotic who had undergone paracentesis after hospitalization included. Those divided into two groups according presence or absence SBP. Factors development SBP analyzed. Mortality rates during within 30 days also analyzed.A total 1140 (median age, 62; men, 75%; model for end-stage liver...
To investigate long-term outcome in obscure gastrointestinal bleeding (OGIB) after negative capsule endoscopy (CE) and identify risk factors for rebleeding.A total of 113 consecutive patients underwent CE OGIB from May 2003 to June 2010 at Seoul National University Hospital. Ninety-five (84.1%) with a subsequent follow-up least 6 mo were enrolled this study. Follow-up data obtained the patients' medical records. The images reviewed by two board-certified gastroenterologists consensus...
With advances in diagnostic endoscopy, the detection of rectal neuroendocrine tumors (NETs) has increased. However, clinical outcomes, especially after endoscopic treatment, are still unclear. The aim this study was to determine long-term outcomes endoscopically resected NETs according pathologic status initial resection.In large, multicenter, retrospective cohort study, we analyzed medical records patients who underwent resection and were followed for ≥24 months at 16 university hospitals....
Abstract Chronic colonic inflammation is a feature of cancer and strongly associated with tumorigenesis, but its underlying molecular mechanisms remain poorly understood. Inflammatory conditions increased ITF2 p65 expression both ex vivo in vivo, showed positive correlations. overexpression stabilized protein levels by interfering the binding Parkin to ITF2. More specifically, C-terminus binds N-terminus inhibits ubiquitination, thereby promoting stabilization. acts as E3 ubiquitin ligase...
The aim of this study was to investigate the role psychosocial problems and their associations with rotating shift work in development functional gastrointestinal disorders.In cross-sectional observation study, survey administered nurses nurse assistants a referral hospital. In addi-tion demographic questions, subjects were asked complete Rome III Questionnaire, Pittsburgh Sleep Quality Index Psychosocial Alarm Questionnaire.Responses from 301 assessed. overall prevalence irritable bowel...
Periostin is a matricellular protein that interacts with various integrin molecules on the cell surface. Although periostin expressed in inflamed colonic mucosa, its role regulation of intestinal inflammation remains unclear. We investigated using Postn-deficient (Postn-/-) mice. Intestinal epithelial cells (IECs) were transfected by Postn small interfering RNAs. expression was determined colon tissue samples from ulcerative colitis (UC) patients. Oral administration dextran sulfate sodium...
Inflammatory bowel diseases is associated with an increased risk for the development of colorectal cancer. However, mechanism immune signaling pathways linked to colitis-associated cancer (CAC) has not been fully elucidated. Tauroursodeoxycholic acid (TUDCA) exhibits anti-inflammatory and anti-cancer activities. The aim this study investigate role TUDCA in pathogenesis CAC.Colitis-associated was induced mice using azoxymethane dextran sodium sulfate administration, TUDCA's effect on tumor...
To investigate the role of sleep quality and psychosocial problems as predictors functional gastrointestinal disorders (FGIDs) in doctors that work 24 hour-on-call shifts.In this cross-sectional observation study, using Rome III Questionnaire Pittsburgh Sleep Quality Index (PSQI), we analyzed 170 with shifts.Among participants had experienced a shift within last 6 mo, 48 (28.2%) FGIDs. Overall prevalence irritable bowel syndrome (IBS) dyspepsia (FD) were 16.5% 17.1%, respectively, 5.3%...
Intestinal fibrosis induced by chronic and recurrent colitis, which is exacerbated bowel stenosis, stricture, obstruction, challenging to treat. Toll-like receptor 4 (TLR4) stimulates innate acquired immunity in response specific microbial components, but the role of TLR4 intestinal largely unknown. We investigated its using not only a murine model also human myofibroblasts epithelial cells. Colon was TLR4-deficient (TLR4-/-) mice wild-type counterparts with 3% dextran sulfate sodium....
There has been a rapid expansion of digital health care services, making the need for measuring and improving readiness priority. In response, our study team developed Mobile-Centered Digital Health Readiness: Literacy Equity Scale (mDiHERS) to measure readiness.