A5058809801- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Nutrition and Health in Aging
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Inflammatory Bowel Disease
- Alcohol Consumption and Health Effects
- Gastrointestinal motility and disorders
- Colorectal Cancer Surgical Treatments
- Gastrointestinal disorders and treatments
- Microscopic Colitis
- Diet, Metabolism, and Disease
- Diverticular Disease and Complications
- Mycobacterium research and diagnosis
- NF-κB Signaling Pathways
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- HIV/AIDS drug development and treatment
- Health, psychology, and well-being
Seoul National University
2015-2024
Boramae Medical Center
2014-2023
Seoul Metropolitan Government
2014-2023
Ulsan College
2021
University of Ulsan
2021
Asan Medical Center
2021
Seoul National University Hospital
2010-2018
Presbyterian Medical Center
2015
New Generation University College
2009-2015
National University College
2009
Abstract Purpose: The poor prognosis of hepatocellular carcinoma (HCC) is, in part, due to the high rate recurrence even after “curative resection” tumors. Therefore, it is axiomatic that development an effective prognostic prediction model for HCC surgery would, at minimum, help identify advance those who would most benefit from treatment, and best, provide new therapeutic strategies patients with a risk early recurrence. Experimental Design: For time HCC, gene expression profiles were...
Abstract Background Helicobacter pylori causes chronic gastritis, gastroduodenal ulcers, and gastric cancer, has been treated with two antibiotics (amoxicillin clarithromycin) proton‐pump inhibitors ( PPI s). However, antibiotic treatment alters the indigenous gut microbiota to cause side effects. Therefore, effects of probiotic supplementation on therapy have studied. Although several studies covered probiotics’ effects, details about changes after H. eradication not evaluated. we analyzed...
Abstract Background and Aims: Although triple combination therapy containing a proton pump inhibitor (PPI) two antibiotics is considered as standard regimen for the first‐line anti‐ Helicobacter pylori treatment, there are still debates on ideal duration of treatment. The aim this study was to compare efficacies 7‐day 14‐day PPI‐containing therapy. Materials Methods: This performed in randomized, multicenter, prospective manner. After upper gastrointestinal endoscopy, H. ‐infected patients...
Aims Metabolic syndrome (MetS) increases the risk of diabetes mellitus (DM), cardiovascular disease (CVD), cancer, and mortality. Sarcopenia has been reported as a factor for MetS, non-alcoholic fatty liver disease, CVD. To date, association between sarcopenia MetS investigated. However, there have few studies on dose-response relationship MetS. We investigated prevalence also aimed to analyze skeletal muscle mass Methods enrolled 13,620 participants from October 2014 December 2019. Skeletal...
The aims of this study were to investigate whether acid suppressive therapy increases the risk spontaneous bacterial peritonitis (SBP) and define factors associated with mortality in cirrhotic patients SBP.Cirrhotic who had undergone paracentesis after hospitalization included. Those divided into two groups according presence or absence SBP. Factors development SBP analyzed. Mortality rates during within 30 days also analyzed.A total 1140 (median age, 62; men, 75%; model for end-stage liver...
The diagnostic performance of supersonic shear imaging (SSI) in comparison with those transient elastography (TE) and acoustic radiation force impulse (ARFI) for staging fibrosis nonalcoholic fatty liver disease (NAFLD) patients has not been fully assessed, especially Asian populations relatively lean NAFLD compared to white populations. Thus, we focused on comparing the performances TE, ARFI, SSI a head-to-head manner, identifying clinical, anthropometric, biochemical, histological features...
Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of heterogeneous metabolic subtypes. This study compared the diagnostic performances noninvasive fibrosis tests in predicting advanced among patients with NAFLD and examined effects subgroups on their performances.Three hundred fifteen biopsy-proven were prospectively enrolled. Acoustic radiation force impulse imaging (ARFI) was performed to obtain stiffness measurements (LSMs). The aspartate aminotransferase-to-alanine...
The aim of this study was to evaluate the prevalence Barrett's esophagus (BE) in general Korean population by evaluating screening esophagogastroduodenoscopy. In addition, risk factors for BE were identified.An esophagogastroduodenoscopy examination performed 25,536 subjects who had upper endoscopy from January 2006 July 2006.Two hundred and fifteen confirmed have pathology, thus calculated be 0.84%. endoscopic findings subdivided into 2 groups: without reflux esophagitis (RE), which...
PatientsWe retrospectively analyzed medical records of the patients who underwent EMR gastric polyps from April 1996 to February 2003 at Seoul Municipal Boramae Hospital.
The aim of this study was to investigate the role psychosocial problems and their associations with rotating shift work in development functional gastrointestinal disorders.In cross-sectional observation study, survey administered nurses nurse assistants a referral hospital. In addi-tion demographic questions, subjects were asked complete Rome III Questionnaire, Pittsburgh Sleep Quality Index Psychosocial Alarm Questionnaire.Responses from 301 assessed. overall prevalence irritable bowel...
To investigate the usefulness of tumor markers and adenosine deaminase in differentiating between tuberculous peritonitis (TBP) peritoneal carcinomatosis (PC).A retrospective analysis data was performed on consecutive patients who underwent peritoneoscopic abdominal computed tomography (CT) evaluations. Among 75 at Seoul National University Hospital from January 2000 to June 2010 both tests, 27 (36.0%) 25 (33.3%) were diagnosed with TBP PC, respectively. Diagnosis confirmed by biopsy.Serum...
Periostin is a matricellular protein that interacts with various integrin molecules on the cell surface. Although periostin expressed in inflamed colonic mucosa, its role regulation of intestinal inflammation remains unclear. We investigated using Postn-deficient (Postn-/-) mice. Intestinal epithelial cells (IECs) were transfected by Postn small interfering RNAs. expression was determined colon tissue samples from ulcerative colitis (UC) patients. Oral administration dextran sulfate sodium...
Inflammatory bowel diseases is associated with an increased risk for the development of colorectal cancer. However, mechanism immune signaling pathways linked to colitis-associated cancer (CAC) has not been fully elucidated. Tauroursodeoxycholic acid (TUDCA) exhibits anti-inflammatory and anti-cancer activities. The aim this study investigate role TUDCA in pathogenesis CAC.Colitis-associated was induced mice using azoxymethane dextran sodium sulfate administration, TUDCA's effect on tumor...
To investigate the role of sleep quality and psychosocial problems as predictors functional gastrointestinal disorders (FGIDs) in doctors that work 24 hour-on-call shifts.In this cross-sectional observation study, using Rome III Questionnaire Pittsburgh Sleep Quality Index (PSQI), we analyzed 170 with shifts.Among participants had experienced a shift within last 6 mo, 48 (28.2%) FGIDs. Overall prevalence irritable bowel syndrome (IBS) dyspepsia (FD) were 16.5% 17.1%, respectively, 5.3%...
Abstract Background & Aims Nonalcoholic fatty liver disease (NAFLD) is known to increase the risk of adenomatous colonic polyps. However, role screening colonoscopy in patients with biopsy‐proven NAFLD detecting advanced colorectal neoplasm not clearly evidence‐based. Therefore, we investigated whether histological severity associated neoplasm. Methods This study included ≥18 years old who underwent between 2013 and 2018 within a biopsy‐evaluated prospective cohort. Advanced was defined...
Non-alcoholic fatty liver disease (NAFLD) affects obese and non-obese individuals. However, mechanisms underlying non-alcoholic steatohepatitis (NASH) remain unclear.To attempt to identify metabolic perturbations associated with NAFLD using a lipidomics approach.A cross-sectional analysis of 361 subjects biopsy-proven (157 NAFL 138 NASH) healthy controls (n = 66) was performed. Individuals were categorised as or based on the Asian cut-off for body mass index. Circulating lipidomic profiling...
Inflammatory bowel disease (IBD) was previously regarded as a Western disease; however, its incidence is increasing in the East. The epidemiology of IBD Asia differs significantly from patterns West.
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea College Seoul, Catholic Health Promotion Center, St. Mary's Ewha Womans School Soonchunhyang Cheonan, Hallym Chonnam Gwangju, Kyungpook Daegu, Chungnam Daejeon, Digestive Research Institute, Wonkwang Iksan, Inje Busan, Yonsei Wonju Wonju, Gachon Gil Medical Incheon, Chungbuk Cheongju, Gangneung Asan Gangneung, Cancer Prevention Korean Ilsan, Kwangju Christian Eulji Kyung Hee SMG-SNU Boramae
Alcoholic liver diseases often evolve to acute-on-chronic failure (ACLF), which increases the risk of (multi-)organ and death. We investigated development characteristics alcohol-related ACLF evaluated prognostic scores for prediction mortality in Asian patients with active alcoholism.A total 205 who were hospitalized severe alcoholic disease included this retrospective cohort study, after excluding those serious cardiovascular diseases, malignancy, or co-existing viral hepatitis. The...
Abstract Background: Identifying hepatitis C virus (HCV) genotypes has become increasingly important for determining clinical course and the outcome of antiviral therapy. Here we describe development restriction fragment mass polymorphism (RFMP) analysis, a novel matrix-assisted laser desorption/ionization time-of-flight spectrometry (MALDI-TOF MS) assay suitable high-throughput, sensitive, specific genotyping multiple HCV species. Methods: The is based on PCR amplification measurement...