A5080724658- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Endoplasmic Reticulum Stress and Disease
- Travel-related health issues
- HIV/AIDS drug development and treatment
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Digital Economy and Work Transformation
- RNA regulation and disease
- Genomics, phytochemicals, and oxidative stress
- Appendicitis Diagnosis and Management
- PI3K/AKT/mTOR signaling in cancer
- Lattice Boltzmann Simulation Studies
- Soft Robotics and Applications
- Ferroptosis and cancer prognosis
- Colorectal Cancer Treatments and Studies
- Toxin Mechanisms and Immunotoxins
- Colorectal Cancer Screening and Detection
- Viral-associated cancers and disorders
- Transportation and Mobility Innovations
- Enhanced Oil Recovery Techniques
- Diverticular Disease and Complications
Dongguk University Ilsan Hospital
2019-2024
California Liver Research Institute
2019
Seoul National University
2001-2019
Seoul National University Hospital
2015
New Generation University College
2001
Biomed Research Institute
2001
Antiplatelet therapy has shown protective effects against hepatocellular carcinoma (HCC) in preclinical studies. However, it is unclear whether antiplatelet lowers the risk of HCC patients with chronic hepatitis B. A retrospective analysis was conducted data from 1,674 B patients, enrolled between January 2002 and May 2015, whose serum virus DNA levels were suppressed by antivirals to <2,000 IU/mL. The primary secondary outcomes development bleeding events, respectively. Risk compared...
Rifaximin might decrease the risk of portal hypertension-related complications by controlling small intestinal bacterial overgrowth.To evaluate whether rifaximin was associated with death and cirrhotic complications.We conducted a retrospective study that included 1042 patients experiencing hepatic encephalopathy (HE): 421 without hepatocellular carcinoma (HCC; non-HCC cohort) 621 HCC (the cohort). The primary endpoint overall survival secondary endpoints were recurrence HE development...
Class I phosphoinositide 3‐kinase (PI3K) signaling is a major pathway in human cancer development and progression. Among the four PI3K isoforms, PI3Kα PI3Kβ are ubiquitously expressed, whereas PI3Kγ PI3Kδ found primarily leukocytes. Until now, targeting solid tumors has focused on inhibiting PI3Kα‐mediated PI3Kβ‐mediated cell–intrinsic activity. The role of unknown. Here, we evaluated effects using established hepatocellular carcinoma (HCC) cells, malignant hepatocytes derived from patients...
Sorafenib is the only approved targeted drug for hepatocellular carcinoma (HCC), but its effect on patients' survival gain limited and varies over a wide range depending pathogenetic conditions. Thus, enhancing efficacy of sorafenib finding reliable predictive biomarker are crucial to achieve efficient control HCCs. In this study, we utilized systems approach by combining transcriptome analysis mRNA changes in HCC cell lines response with network investigate action resistance mechanism...
ABSTRACT The emergence of multidrug-resistant (MDR) strains hepatitis B virus (HBV) is a major concern. This study aimed to investigate the efficacy and safety combination therapy with entecavir (ETV) plus tenofovir disoproxil fumarate (TDF) against MDR HBV. To adjust for differences in baseline characteristics, inverse probability weighting (IPW) using propensity scores entire cohort weighted Cox proportional hazards models were applied. Ninety-three consecutive patients who treated ETV-TDF...
Alcoholic liver diseases often evolve to acute-on-chronic failure (ACLF), which increases the risk of (multi-)organ and death. We investigated development characteristics alcohol-related ACLF evaluated prognostic scores for prediction mortality in Asian patients with active alcoholism.A total 205 who were hospitalized severe alcoholic disease included this retrospective cohort study, after excluding those serious cardiovascular diseases, malignancy, or co-existing viral hepatitis. The...
Although nonalcoholic fatty liver disease (NAFLD) is a risk factor of hepatocellular carcinoma (HCC), it unclear whether NAFLD additionally increases the HCC among chronic hepatitis B (CHB) patients. This study evaluated association between and in patients whose virus (HBV) was well controlled.This included consecutive CHB serum HBV DNA levels were continuously suppressed <2000 IU/mL with antiviral treatment. Fatty radiologically diagnosed. Patients concomitant C infection, autoimmune...
Acquisition of anoikis resistance is a prerequisite for metastasis in hepatocellular carcinoma (HCC). However, little known about how energy metabolism and antioxidant systems are altered anoikis-resistant (AR) HCC cells. We evaluated anti-tumor effects combination treatment 3-bromopyruvate (3-BP) buthionine sulfoximine (BSO) AR cells.We compared glycolysis, reactive oxygen species (ROS) production, chemoresistance among Huh-BAT, HepG2 cells, the corresponding Expression hexokinase II,...
Summary Nucleos(t)ide analogues ( NA s) have been shown to decrease the risk of hepatocellular carcinoma HCC ) recurrence. This study evaluated whether high‐potency s (entecavir and tenofovir disoproxil fumarate [ TDF ]) reduce tumour recurrence more potently than low‐potency after curative treatment hepatitis B virus HBV )‐related . included 607 consecutive ‐related patients treated with surgical resection or radiofrequency ablation. The were categorized into three groups according...
Nucleot(s)ide analogues (NAs) reduce the risk of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients. However, HCC is reportedly higher for NA-treated patients than inactive CHB phase. This study aimed to compare long-term outcomes with NA-induced viral suppression and those CHB. retrospective involved 1118 consecutive whose HBV DNA level was continuously <2000 IU/mL during follow-up with/without antiviral agents. The were classified into (n = 373) or NA groups 745). primary...
The role of sorafenib in patients with hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) has been rarely studied. aim this study was to evaluate the efficacy post-LT era. Consecutive post-transplant HCC not eligible resection or locoregional therapy were included. Patients receiving best supportive care (BSC) until 2007 compared those treated by thereafter. Of a total 65 patients, 20 received BSC and 45 sorafenib. Clinical characteristics similar between two groups...
ABSTRACT Tenofovir disoproxil fumarate (TDF) monotherapy is a therapeutic option for chronic hepatitis B (CHB) patients infected with virus (HBV) variants resistant to lamivudine (LAM). We evaluated the antiviral efficacy and safety of TDF alone compared those plus LAM or telbivudine (LdT) combination in harboring HBV genotypic resistance LAM. This multicenter retrospective study included consecutive who had LAM-resistant were treated (monotherapy group) combined LdT (combination therapy at...
Data are insufficient regarding the survival benefit of surveillance for hepatocellular carcinoma (HCC).To investigate effectiveness HCC in a hepatitis B-endemic population.This retrospective cohort study included 1402 consecutive patients who were newly diagnosed with between 2005 and 2012 at single tertiary hospital Korea. The primary endpoint was overall survival. Lead-time length-time biases adjusted (sojourn time = 140 days) sensitivity analyses performed.The most common aetiology B...
Advanced liver fibrosis is associated with recurrence after curative resection of hepatocellular carcinoma (HCC). This study aimed to investigate whether noninvasive indices could predict intrahepatic and death HCC.Patients who underwent for hepatitis B virus (HBV)-related HCC between 2006 2010 at a single tertiary hospital were included. analysed the association overall survival.A total 303 patients During median follow-up period 56.0 (interquartile range, 42.0-70.0) months, 151 (49.8%)...
Tenofovir disoproxil fumarate (TDF) is effective against chronic hepatitis B (CHB) infection and its use increasing rapidly worldwide. However, it has been established that TDF associated with renal toxicity in human immunodeficiency virus-infected patients, while severe or symptomatic TDF-associated nephrotoxicity rarely reported patients CHB. Here we present two who were being treated for CHB infection. The first patient was found to have clinical manifestations of proximal tubular...
Background/Aims Protein disulfide isomerase (PDI) has been implicated in the survival and progression of some cancer cells, by compensating for endoplasmic reticulum stress upregulating protein-folding capacity. However, its prognostic role patients with hepatocellular carcinoma (HCC) not investigated. Methods We collected HCC tissues from 83 who underwent surgical resection an immunohistochemical study PDI. Overall (OS) was measured date until death any cause. Radiological evaluated using...
Summary The treatment option in chronic hepatitis B ( CHB ) patients with persistent low‐level viremia despite entecavir or tenofovir monotherapy is unclear. This study investigated the development of hepatocellular carcinoma HCC cirrhosis e antigen HB eAg)‐positive high viral load patients, according to time needed achieve complete suppression. A total 325 eAg‐positive who were recently started on antiviral therapy included. enrolled divided into 2 groups 4 separate criteria based...
Objective: Long-term prognosis of hepatocellular carcinoma (HCC) remains poor owing to the lack treatment options for advanced HCC. Cytokine-induced killer (CIK) cells are ex vivo expanded T lymphocytes expressing both NK– and T-cell markers. CIK cell therapy alone is insufficient treating Thus, this study aimed determine whether with combined valproic acid (VPA) could provide a synergistic effect inhibit tumor growth in mouse model Methods: Upregulation natural group 2D (NKG2D) ligands...
Minjong Lee, Young Chang, Sohee Oh, Youn Cho, Dhong-Eun Jung, Hong Hyun Kim, Joon Yeul Nam, Hyeki Eun Ju Jeong-Hoon Su Jong Yu, Nam-Joon Yi, Kwang-Woong Dong Ho Jeong Min Jung-Hwan Yoon, Kyung-Suk Suh, and Yoon Jun Kim. Gut Liver 2018;12:571-82. https://doi.org/10.5009/gnl17365
Whether a sustained virological response (SVR) improves long-term outcomes in chronic hepatitis C patients with earlier-stage fibrosis has not been established. We investigated the differential effect of SVR on risk according to hepatic grade. Fibrosis grade was categorised using FIB-4: <1.45, low-probability significant fibrosis; 1.45-3.25, intermediate-probability; and ≥3.25, high-probability. Primary secondary endpoints were hepatocellular carcinoma (HCC) occurrence death, respectively....
Abstract Colorectal cancer (CRC) is one of the top five most common and life-threatening malignancies worldwide. Most CRC develops from advanced colorectal adenoma (ACA), a precancerous stage, through adenoma-carcinoma sequence. However, its underlying mechanisms, including how tumor microenvironment changes, remain elusive. Therefore, we conducted an integrative analysis comparing RNA-seq data collected 40 ACA patients who visited Dongguk University Ilsan Hospital with normal adjacent...
Background/Aims Regular surveillance for hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients is essential to detect HCC earlier and improve prognosis. This study investigated whether prescription of oral medication contributes adherence surveillance, early tumor detection, overall survival (OS). Methods A total 401 CHB who were newly diagnosed with included: 134 received no (group 1), 151 hepatoprotective agents such as ursodeoxycholic acid silymarin 2), 116 antiviral 3) at...
Combination of midazolam and opioids is used widely for endoscopic sedation. Compared with meperidine, fentanyl reportedly associated rapid recovery, turnover rate endoscopy room, quality endoscopy. We compared meperidine when combined sedative colonoscopy.A retrospective, cross-sectional, 1:2 matching study was conducted. Induction recovery time were as the primary outcomes. Moreover, cecal intubation time, withdrawal total procedure colonoscopy, paradoxical reaction, adenoma detection...
Dietary fiber intake is considered a protective factor for diverticular disease such as diverticulitis. However, evidence an inverse connection between dietary consumption and asymptomatic colonic diverticulosis lacking. Specifically, few studies have investigated this subject in Asians with different presentations of diverticulosis. Therefore, we assessed the effects vegetarian diet Buddhist monks who are obligatory vegetarians spiritual reasons compared general population. A retrospective,...