A5061231855- Lymphoma Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Hair Growth and Disorders
- Asthma and respiratory diseases
- Neurogenetic and Muscular Disorders Research
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Amyotrophic Lateral Sclerosis Research
- Neurological diseases and metabolism
- Genomics and Chromatin Dynamics
- Inflammatory Myopathies and Dermatomyositis
- Plant Reproductive Biology
- Cancer Immunotherapy and Biomarkers
- Galectins and Cancer Biology
- Uterine Myomas and Treatments
- Gynecological conditions and treatments
- Colorectal Cancer Treatments and Studies
- Cytokine Signaling Pathways and Interactions
- Genetic Syndromes and Imprinting
- Single-cell and spatial transcriptomics
- RNA Research and Splicing
- melanin and skin pigmentation
- Endometriosis Research and Treatment
- Biosensors and Analytical Detection
- Genetic factors in colorectal cancer
Dongguk University
2019-2024
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative neuromuscular disease. Although genome-wide association studies (GWAS) have successfully identified many variants significantly associated with ALS, it still difficult to characterize the underlying biological mechanisms inducing ALS. In this study, we performed transcriptome-wide study (TWAS) identify disease-specific genes in Using largest ALS GWAS summary statistic (n = 80,610), seven novel using 19 tissue reference panels. We...
Psoriasis is a chronic inflammatory skin disease characterized by cutaneous eruptions and pruritus. Because the genetic backgrounds of psoriasis are only partially revealed, an integrative rigorous study necessary. We conducted transcriptome-wide association (TWAS) with new Genotype-Tissue Expression version 8 reference panels, including some tissue multi-tissue panels that were not used previously. performed tissue-specific heritability analyses on genome-wide data to prioritize for TWAS...
Abstract Background Juvenile idiopathic arthritis (JIA) is one of the most prevalent rheumatic disorders in children and classified as an autoimmune disease (AID). While a robust genetic contribution to JIA etiology has been established, exact pathogenesis remains unclear. Methods To prioritize biologically interpretable susceptibility genes proteins for JIA, we conducted transcriptome-wide proteome-wide association studies (TWAS/PWAS). Then, understand architecture systematically analyzed...
Abstract Colorectal cancer (CRC) is one of the top five most common and life-threatening malignancies worldwide. Most CRC develops from advanced colorectal adenoma (ACA), a precancerous stage, through adenoma-carcinoma sequence. However, its underlying mechanisms, including how tumor microenvironment changes, remain elusive. Therefore, we conducted an integrative analysis comparing RNA-seq data collected 40 ACA patients who visited Dongguk University Ilsan Hospital with normal adjacent...
Uterine fibroid is one of the most prevalent benign tumors in women, with high socioeconomic costs. Although genome-wide association studies (GWAS) have identified several loci associated uterine risks, they could not successfully interpret biological effects genomic variants at gene expression levels. To prioritize susceptibility genes that are biologically interpretable, we conducted a transcriptome-wide study (TWAS) by integrating GWAS data and quantitative data. We nine significant TWAS...
Food intolerance is delayed adverse food reactions which follow consumption of specific foods. The underlying mechanisms are not well understood, but often considered as a type 2 hypersensitivity reaction mediated by immunoglobulin G (IgG) antibody. To understand the causes intolerance, it important to investigate sensitization patterns food-specific IgGs (sIgG) in relation dietary and physical conditions. Conventional approaches measure serological require large volumes serum, thus suitable...
Abstract Background Male-pattern baldness (MPB) is the most common cause of hair loss in men. It can be categorized into three types: type 2 (T2), 3 (T3), and 4 (T4), with 1 (T1) being considered normal. Although various MPB-associated genetic variants have been suggested, a comprehensive study for linking these to gene expression regulation has not performed best our knowledge. Results In this study, we prioritized MPB-related tissue panels using tissue-specific enrichment analysis utilized...
Male-pattern baldness (MPB) is the most common cause of hair loss in men. It can be categorized into three types: type 2 (T2), 3 (T3), and 4 (T4), with 1 (T1) being considered normal. Although various MPB-associated genetic variants have been suggested, a comprehensive study for linking these to gene expression regulation has not performed best our knowledge. In this study, we prioritized MPB-related tissue panels using tissue-specific enrichment analysis utilized single-tissue from...
Abstract Objectives Juvenile idiopathic arthritis (JIA) is one of the most prevalent rheumatic disorders in children and classified as an autoimmune disease (AID). While a robust genetic contribution to JIA etiology has been established, exact pathogenesis remains unclear. We conducted comprehensive integrative analysis gain new insights into JIA. Methods To prioritize biologically interpretable susceptibility genes proteins for JIA, we transcriptome-wide proteome-wide association studies...