A5050380300- Reproductive Biology and Fertility
- Pancreatic and Hepatic Oncology Research
- Alkaline Phosphatase Research Studies
- Diverse Approaches in Healthcare and Education Studies
- Ovarian cancer diagnosis and treatment
- Nutrition and Health in Aging
- Korean Urban and Social Studies
- Pancreatic function and diabetes
- Phagocytosis and Immune Regulation
- Pancreatitis Pathology and Treatment
- Diverse Topics in Contemporary Research
- Health and Wellbeing Research
- Psychosocial Factors Impacting Youth
- Hepatitis B Virus Studies
- Child and Adolescent Psychosocial and Emotional Development
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Advanced biosensing and bioanalysis techniques
- Parathyroid Disorders and Treatments
- Renal and related cancers
- Traditional Chinese Medicine Studies
- Diabetes Management and Education
- Diet, Metabolism, and Disease
- Endoplasmic Reticulum Stress and Disease
- Metabolism, Diabetes, and Cancer
Dongguk University
2007-2023
University of Nebraska Medical Center
2020-2023
Seoul National University Bundang Hospital
2009-2023
Ewha Womans University
2016-2022
Kyungpook National University
2008-2021
Charlottesville Medical Research
2021
Hallym University
2020
Hallym University Sacred Heart Hospital
2020
University of Virginia
2020
Korea Institute of Science and Technology
2019
OBJECTIVE To improve quality and efficiency of care for elderly patients with type 2 diabetes, we introduced elderly-friendly strategies to the clinical decision support system (CDSS)-based ubiquitous healthcare (u-healthcare) service, which is an individualized health management using advanced medical information technology. RESEARCH DESIGN AND METHODS We conducted a 6-month randomized, controlled trial involving 144 aged >60 years. Participants were randomly assigned receive routine...
GLUT2 is mainly expressed in the liver, β-cells of pancreas, and basolateral membrane kidney proximal tubules plays an important role glucose homeostasis living organisms. The transcription gene known to be upregulated liver during postprandial hyperglycemic states or type 2 diabetes. However, a molecular mechanism by which activates expression not known. In this study, we report evidence that sterol response element–binding protein (SREBP)-1c key glucose-stimulated expression. promoter...
Protein-cage nanoparticles are promising multifunctional platforms for targeted delivery of imaging and therapeutic agents owing to their biocompatibility, biodegradability, low toxicity. The major advantage protein-cage is the ability decorate surfaces with multiple functionalities through genetic chemical modification achieve desired properties and/or diagnostic purposes. Specific peptides identified by phage display can be genetically fused onto surface cage proteins promote association a...
Abstract A growing appreciation of the relationship between immune system and tumorigenesis has led to development strategies aimed at “re‐editing” kill tumors. Here, a novel tactic is reported for overcoming activation‐energy threshold immunosuppressive tumor microenvironment mediating delivery presentation neoantigens host's system. This nature‐derived nanocage not only efficiently presents ligands that enhance cancer cell phagocytosis, but also delivers drugs induce immunogenic death. The...
The regulation of hepatic glucose metabolism is important in homeostasis, and liver glucokinase (LGK) plays a central role this process. Hepatic expression known to be regulated by insulin. Recently it has been suggested that sterol regulatory element binding protein-1c (SREBP-1c) mediates the action insulin on LGK transcription; however, precise mechanism not, date, well known. In present study, we identified two functional SREBP-1c response elements, SREa SREb, rat promoter. could bind...
The removal of unwanted or damaged cells by phagocytes is achieved via a finely regulated cleaning process called efferocytosis. To characterize the mechanisms through which control intake apoptotic cells, we investigated how phagocyte's appetite for engulfed may be coordinated RhoA and Rac1 in phagocytic cup. We used FRET biosensors to visualize spatiotemporal dynamics Rho-family GTPases, found that RhoA, known downregulated during phagocytosis, was transiently upregulated at cup...
Since mid-December of 2019, coronavirus disease 2019 (COVID-19) has been spreading from Wuhan, China. As February 21, total 75,773 confirmed cases worldwide have spread to more than two dozen countries. Transmission COVID-19 can occur early in the course infection since SARS-CoV-2 viral loads asymptomatic patients are similar that symptomatic patients. Therefore, sensitive diagnostic methods needed detect phase prevent secondary or tertiary spreads. Here, we compare RT-PCR confirmatory test...
Chemotherapy directly or indirectly affects organs in a short-term continuous manner. Endocrine are especially sensitive to cancer treatment, leading concerns among patients regarding their quality of life afterward. Side effects the ovary include damage ovarian reserve, resulting follicle loss, endocrine hormone deficiency, and infertility. It has been previously demonstrated that treatment with 2 mg/kg cisplatin for 15 days can activate primordial follicles, suggesting response oocytes...
Abstract Background Immobilization with cervical spine worsens endotracheal intubation condition. Though various devices have been demonstrated to perform well in oral intubation, limited information is available concerning nasotracheal (NTI) patients immobilization. The present study compared the performance of C-MAC D-Blade videolaryngoscope McCoy laryngoscope for NTI simulated injuries. Methods This was a prospective, randomized, controlled, done tertiary hospital. Ninety-five requiring...
Immunotherapy has emerged at the forefront of cancer treatment. Checkpoint inhibitor pembrolizumab (KEYTRUDA), a chimeric antibody which targets programmed cell death protein 1 (PD-1), been approved by Food and Drug Administration (FDA) for use in pediatric patients with relapsed or refractory classical Hodgkin's lymphoma. However, there is currently no published data regarding effects on ovary female patients. In this study, prepubertal immunocompetent immunodeficient mice were injected...
The immature oocytes within primordial follicles are arrested at Prophase I of meiosis and remain dormant until awakened by an increase in intracellular levels phosphatidylinositol (3,4,5)-trisphosphate (PIP3). Oocyte PIP3 level is determined the balance between activity phosphoinositide 3-kinase (PI3K) phosphatase tensin homologue (PTEN). When this favours PI3K, elevate trigger cascade PI3K/protein kinase B (AKT)/mammalian target rapamycin (mTOR) pathway, leading to activation follicles....
Pancreatic ductal adenocarcinoma (PDAC) patients display distinct phenotypes of cachexia development, with either adipose tissue loss preceding skeletal muscle wasting or only tissue. Activin A levels were measured in serum and analyzed tumor specimens both a cohort Stage IV PDAC the genetically engineered KPC mouse model. Our data revealed that activin significantly elevated comparison to age-matched non-cancer patients. Little is known about role setting cancer cachexia. We established...
Most studies on gaming addiction have targeted adolescents in schools, while among out-of-school remain scarce. Therefore, this study investigated the influence of parental and peer attachment addiction, mediated by social stigma Korean adolescents. The Dropout Youth Panel Survey was used for a sample 437 dropout results showed that adolescents’ fully relationship between addiction. Parental significantly predicted decreasing their stigma. Peer also influenced via effects No direct effect...
A number of peptide-based indicators have been identified and reported as potential apoptosis probes, offering great promise for early assessment therapeutic efficacy in several types cancer. Direct comparison the newly developed probes with previously used ones would be an important step assessing possible applications. Here, we compared phosphatidylserine (PS) indicator PSP1 (CLSYYPSYC) annexin V, a common probe molecular imaging apoptotic cells, respect to PS binding kinetics,...
Abstract Cancer-associated cachexia (CAC) is a complex metabolic and behavioral syndrome with multiple manifestations that involve systemic inflammation, weight loss, adipose lipolysis. It impacts the quality of life patients direct cause death in 20%–30% cancer patients. The severity fat loss tissue remodeling negatively correlate patients’ survival outcomes. To address mechanism design potential approaches to prevent process, it will be essential understand CAC pathophysiology through...
Arterial stiffness (AS) and obesity are recognized as important risk factors of cardiovascular disease (CVD). The purpose this study was to investigate the relationship between AS obesity. defined high augmentation index (AIx) low elasticity (C1, large artery elasticity; C2, small elasticity) in participants enrolled Multi-Ethnic Study Atherosclerosis at baseline. We compared AIx, C1, C2 by body mass (BMI) (< 25, 25–29.9, 30–39.9, ⩾ 40 kg/m 2 ) waist–hip ratio (WHR) 0.85, 0.85–0.99, 1)....
Salt-leaching using powder (SLUP) scaffolds are novel salt-leaching with well-interconnected pores that do not require an organic solvent or high pressure. In this study, in vitro and vivo cell behaviors were assessed a PCL (polycaprolactone) SLUP scaffold. Moreover, PCL, conventional 3D-plotted fabricated as control scaffolds. Morphology, mechanical property, water absorption, vitro/in response assessments performed to clarify the characteristics of scaffold compared Consequently, we...
Abstract TRAIL is considered a promising target for cancer therapy because it mediates activation of the extrinsic apoptosis pathway in tumor-specific manner by binding to and trimerizing its functional receptors, DR4 or DR5. Although recombinant human has shown high potency specificity killing cells preclinical studies, failed multiple clinical trials several reasons, including very short half-life mainly caused instability monomeric form rapid renal clearance off-targeted TRAIL. To...