A5063153939- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Helicobacter pylori-related gastroenterology studies
- Liver Diseases and Immunity
- Viral gastroenteritis research and epidemiology
- Gastric Cancer Management and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Systemic Lupus Erythematosus Research
- Viral Infections and Immunology Research
- Veterinary medicine and infectious diseases
- Alcohol Consumption and Health Effects
- Gastrointestinal Bleeding Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Iron Metabolism and Disorders
- RNA Interference and Gene Delivery
- HIV/AIDS drug development and treatment
Seoul National University Bundang Hospital
2015-2024
National University College
2010-2024
New Generation University College
2010-2024
Seoul National University
2015-2024
Health Net
2024
CymaBay Therapeutics (United States)
2024
Pusan National University Hospital
2023
ORCID
2021
Weatherford College
2021
Gyeongsang National University Hospital
2016
Nonalcoholic fatty liver disease (NAFLD) is related to risk factors of coronary artery disease, such as dyslipidemia, diabetes, and metabolic syndrome, which are closely linked with visceral adiposity. The aim this study was investigate whether NAFLD associated calcification (CAC), used a surrogate marker for atherosclerosis independent computed tomography (CT)-measured Out 5,648 subjects who visited one our health screening centers between 2003 2008, we enrolled 4,023 (mean age, 56.9 ± 9.4...
ENHANCE was a phase 3 study that evaluated efficacy and safety of seladelpar, selective peroxisome proliferator-activated receptor-δ (PPAR) agonist, versus placebo in patients with primary biliary cholangitis inadequate response or intolerance to ursodeoxycholic acid (UDCA).
Effective treatments for patients with primary biliary cholangitis are limited. Seladelpar, a peroxisome proliferator-activated receptor delta agonist, has potential benefits.
Recombinant hepatitis C virus (HCV)-like particles (HCV-LPs) containing HCV structural proteins (core, E1, and E2) produced in insect cells resemble the putative virions are capable of inducing strong broad humoral cellular immune responses mice baboons. Here, we present evidence on immunogenicity induction protective immunity by HCV-LPs chimpanzees. Chimpanzees (two each group), were immunized with or plus AS01B adjuvant. After immunizations, all animals developed an HCV-specific response...
Background/Aims Portal-vein thrombosis (PVT) develops in 10-25% of cirrhotic patients and may aggravate portal hypertension. There are few data regarding the effects anticoagulation on nonmalignant PVT liver cirrhosis. The aim this study was to elucidate safety, efficacy, predictors response therapy patients. Methods Patients with cirrhosis were identified by a hospital electronic medical record system (called BESTCARE). malignant PVT, Budd-Chiari syndrome, underlying primary hematologic...
Background & Aims Alpha-fetoprotein (AFP) is the most widely used serum biomarker for hepatocellular carcinoma (HCC), despite its limitations. As complementary biomarkers, protein induced by vitamin K absence (PIVKA-II), osteopontin (OPN), and Dickkopf-1 (DKK-1) have been proposed. This study aimed to perform a head-to-head comparison of diagnostic performance AFP, PIVKA-II, OPN DKK-1 as single or in combination seek best panel, investigate clinical factors affecting their performance....
Clevudine is a pyrimidine analogue with potent and sustained antiviral activity against HBV. The present study evaluated the safety efficacy of 30 mg clevudine once daily for 24 weeks assessed durable response after cessation dosing. A total 243 hepatitis B e antigen (HBeAg)-positive chronic patients were randomized (3:1) to receive (n = 182) or placebo 61) weeks. Patients followed further off therapy. Median serum HBV DNA reductions from baseline at week 5.10 0.27 log10 copies/mL in groups,...
Osteopontin (OPN) is a secreted glycoprotein, frequently associated with various tumors. We investigated the usefulness of plasma OPN level as biomarker for hepatocellular carcinoma (HCC).We determined levels OPN, alpha-fetoprotein (AFP), and prothrombin induced by vitamin K absence II (PIVKA II) in group 62 HCC patients, 60 patients chronic liver diseases, healthy control individuals using standardized ELISA kit. To determine source elevated immunohistochemical analysis 285 samples on...
We have previously reported the production of hepatitis C virus-like particles (HCV-LP) using a recombinant baculovirus containing cDNA HCV structural proteins (core, E1, and E2). These resemble putative virions are capable inducing strong broad humoral cellular immune responses in mice. Here we present evidence on immunogenicity HCV-LP effects novel adjuvant systems nonhuman primate model, baboon. Three groups four baboons were immunized with HCV-LP, AS01B (monophosphoryl lipid A QS21), or...
This study was performed to evaluate whether the addition of probiotics proton pump inhibitor (PPI)-based triple therapy increases likelihood successful Helicobacter pylori eradication.Three hundred and forty-seven H. pylori-infected patients were randomized into a triple-plus-yogurt group (yogurt group, n = 168) or triple-only (control 179). Triple consisted PPI b.i.d., clarithromycin 500 mg amoxicillin 1 g b.i.d. for 7 days. Yogurt received week one bottle Will yogurt per day at 3 weeks,...
Clevudine is a pyrimidine analog with potent and sustained antiviral activity against HBV. In the present study, we evaluated safety efficacy of clevudine 30 mg daily for 24 weeks assessed durability response after cessation dosing in hepatitis B e antigen (HBeAg)-negative chronic (e-CHB). We randomized total 86 patients (3:1) to receive (n = 63) or placebo 23) weeks. followed an additional withdrawal treatment. The median changes HBV DNA from baseline were -4.25 -0.48 log(10) copies/mL at...
Abstract Background: The eradication rate of first‐line Helicobacter pylori treatment is only 70–85% and has been decreasing due to the increase in antibiotic resistance. aim this study was evaluate efficacy bismuth‐containing quadruple therapy as second‐line for H. infection based on duration. Methods: We prospectively enrolled 227 patients that were found have persistent after proton‐pump inhibitor‐clarithromycin‐amoxicillin triple therapy. Patients randomized 1‐week (112 patients) 2‐week...
Abstract Background The eradication rate with PPI ‐based standard triple therapy for Helicobacter pylori infection has fallen considerably. One recent innovation is sequential and three antibiotics, but the complexity of this regimen may reduce its usability. Concomitant administration nonbismuth quadruple drugs (concomitant therapy) also an effective treatment strategy. To investigate which a reasonable choice K orean population, we performed two pilot studies concomitant therapies. Methods...
The aim of this study was to reveal nationwide seroprevalence HCV infection in South Korea by a large-scale survey.From January December 2009, total 291 314 adults underwent health check-up 29 centres nationwide. data concerning anti-HCV antibody and biochemical tests were obtained from all participants. Among subjects with positive anti-HCV, such as RNA, genotypes treatment detail additionally analysed.Using an estimated 2009 population Korea, the age, sex area-adjusted rate 0.78%. Anti-HCV...
Abstract Background Liver function tests (LFTs) can be affected by many factors and the proposed effects of coffee on LFT require a comprehensive evaluation. The aim this study was to elucidate whether drinking coffee, smoking, or alcohol have independent LFTs in Korean health-check examinees. Methods We used responses 500 examinees, who had participated self-administered questionnaire survey about drinking, smoking habits. Results Coffee consumption closely related male gender, high body...
Summary Background As a rare disease, only few population‐based epidemiology studies of primary biliary cirrhosis ( PBC ) have been reported. Aims To elucidate the nationwide prevalence, incidence, complications, fatality and direct medical costs in South Korea. Methods The Health Insurance Review Assessment Service claims data Rare Intractable Disease registration on , identified with International Classification Diseases ICD 10 code K74.3, were obtained from 2009 to 2013. Age‐...
Health care workers (HCWs) are at high risk for occupational blood exposures (OBEs) and transmission of bloodborne pathogens. This study elucidated the incidence rate epidemiological characteristics OBEs among HCWs investigated pathogen hepatitis B virus (HBV), C (HCV), human immunodeficiency (HIV).Self-reported from January 1, 2011 to December 31, 2015 were obtained electronic recording system. OBE densities per 100 person-years bed-years calculated with a 5-year trend analysis. rates...
The role of serum myokine levels in sarcopenia and the outcome hepatocellular carcinoma (HCC) patients are not clear. This study investigated myostatin, follistatin, interleukin-6 (IL-6) HCC their association with survival.Using prospectively collected pretreatment samples from 238 a hospital 2012 to 2015, 3 myokines were determined compared 50 age sex-matched healthy controls. Sarcopenia was evaluated using psoas muscle index (PMI) measured at third lumbar level computed tomography,...
Background Biliary cystadenoma (BCA) and biliary cystadenocarcinoma (BCAC) are often confused with other intrahepatic cystic diseases. Aims The aims of this study were to investigate predictive factors tumor (BCT) clinical characteristic BCAC. Methods We retrospectively reviewed preoperative diagnoses, overall characteristics postoperative outcome 20 BCTs 19 cystadenoma-mimicking simple cysts that pathologically confirmed. Results Comparing atypical cysts, symptoms, left-lobe cyst, thick...