A5103053815- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Gallbladder and Bile Duct Disorders
- Hepatitis B Virus Studies
- Renal Transplantation Outcomes and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Drug-Induced Hepatotoxicity and Protection
- Metabolism and Genetic Disorders
- Abdominal vascular conditions and treatments
- Inflammatory Bowel Disease
- Lipoproteins and Cardiovascular Health
- Organ Donation and Transplantation
- Helicobacter pylori-related gastroenterology studies
- Drug Transport and Resistance Mechanisms
- Cannabis and Cannabinoid Research
- Alkaline Phosphatase Research Studies
- Lymphoma Diagnosis and Treatment
- Muscle and Compartmental Disorders
- Spondyloarthritis Studies and Treatments
- Celiac Disease Research and Management
- Oral Health Pathology and Treatment
Gold Coast Hospital
2025
University of Colorado Anschutz Medical Campus
2009-2024
University of Colorado Denver
2013-2024
University of St. Gallen
2023
University of Colorado Health
2002-2009
University of Wisconsin–Madison
2002-2004
University of Colorado Hospital
2004
Center for Clinical Research (United States)
2002
University of Pennsylvania
2000-2002
Hospital of the University of Pennsylvania
2000
Patients with advanced hepatitis C virus (HCV) are at risk of death and candidates for liver transplantation. After transplantation, HCV recurs may rapidly progress to cirrhosis graft loss. Treatment is needed prevent progression disease minimize recurrence after We evaluated the effectiveness, tolerability, outcome a low accelerating dose regimen (LADR) antiviral therapy in treatment patients HCV. One hundred twenty-four (male/female ratio 81:43; age range 37-71 years; 70% genotype 1) were...
WHAT'S NEW SINCE THE 2010 GUIDELINES? Inclusion of guidance for the diagnosis and management cholangiocarcinoma (CCA) in patients with without primary sclerosing cholangitis (PSC) (Figures 5, 8, 9). Introduction term relevant stricture, defined as any biliary stricture common hepatic duct or ducts associated signs symptoms obstructive cholestasis and/or bacterial (Table 1). In equivocal MRI cholangiopancreatography (MRI/MRCP) findings, a repeated high‐quality MRI/MRCP should be performed...
ENHANCE was a phase 3 study that evaluated efficacy and safety of seladelpar, selective peroxisome proliferator-activated receptor-δ (PPAR) agonist, versus placebo in patients with primary biliary cholangitis inadequate response or intolerance to ursodeoxycholic acid (UDCA).
In Brief Objective: To determine whether patient and graft survival following transplantation with non-heart-beating donor (NHBD) hepatic allografts is equivalent to heart-beating-donor (HBD) allografts. Summary Background Data: With the growing disparity between number of patients awaiting liver a limited supply cadaveric organs, there renewed interest in use from NHBDs. Limited outcome data addressing this issue exist. Methods: Retrospective evaluation among adult recipients NHBD compared...
Background: Rosiglitazone maleate is the second approved oral hypoglycemic agent of thiazolidinedione class. The first, troglitazone, has been associated with liver failure, occasionally resulting in transplantation or death. There have no reports to date rosiglitazone-associated elevations alanine aminotransferase level hepatotoxicity. Objective: To report clinical characteristics failure developing a patient receiving rosiglitazone. Design: Case report. Setting: University hospital....
In natural history studies of hepatitis C virus (HCV) infection, women have a lower risk disease progression to cirrhosis. Whether female sex influences outcomes HCV in the posttransplantation setting is unknown. All patients transplanted for HCV-related liver from 2002-2007 at five United States transplantation centers were included. The primary outcome was development advanced disease, defined as biopsy-proven bridging fibrosis or Secondary included death, graft loss, and loss with...
Cannabis is increasingly used in Parkinson disease (PD), despite little information regarding benefits and risks.
Primary sclerosing cholangitis (PSC) is frequently associated with pruritus, which significantly impairs quality of life. Maralixibat a selective ileal bile acid transporter (IBAT) inhibitor that lowers circulating (BA) levels and reduces pruritus in cholestatic liver diseases. This the first proof-of-concept study IBAT inhibition PSC.This open-label evaluated safety tolerability maralixibat ≤10 mg/d for 14 weeks adults PSC. Measures biomarkers BA synthesis, cholestasis, function were also...
Background: Native joint septic arthritis (NJSA) of the hand is poorly studied. Management guidelines are extrapolated from large infections despite differences in epidemiology, anatomy and aetiology. Limited evidence suggests shorter courses antibiotics can achieve outcomes comparable to longer courses. The aim our study characterise presentation, management NJSA an adult cohort Southeast Queensland (SEQ) determine if route or duration affected outcome. Our was compared those literature...
The allocation system based on the Model for End-stage Liver Disease (MELD) has led to more patients diagnosed with hepatocellular carcinoma (HCC) being transplanted. We hypothesized that misdiagnosed HCC are also transplanted, leading inappropriate organ allocation. Therefore, we retrospectively analyzed all liver transplants at our center from July 14, 2000, October 22, 2002 (N = 172; 129 pre-MELD, 43 post-MELD), comparing pretransplant diagnosis explant histology. Thirty met United...
Over the last decade, use of liver grafts from hepatitis C virus antibody-positive donors [HCV(+)Ds] has tripled in United States. Although previous studies have demonstrated no association between an HCV(+)D status and graft loss, effects on histological outcomes are not well known. Hepatitis (HCV)-infected recipients at 5 US centers (2002-2007) who survived more than 30 days with 1 or posttransplant biopsy samples were included. Cox regression was used to examine advanced fibrosis (stage...
Patients with primary biliary cholangitis (PBC) often suffer pruritus. We describe the impact of pruritus on quality life and how it is managed in a real-world cohort.TARGET-PBC longitudinal observational cohort patients PBC across USA. Data include information from medical records for three years prior to date consent up 5 follow-up. Enrolled were asked complete patient-reported outcome surveys: PBC-40, 5-D itch, PROMIS fatigue survey. Kruskal-Wallis tests used compare differences symptoms...
Patients with primary sclerosing cholangitis (PSC) are at increased risk for bacterial because of biliary strictures and bile stasis. A subset PSC patients suffer from repeated episodes cholangitis, which can lead to frequent hospitalizations impaired quality life. Although waitlist candidates frequently receive exception points and/or referred living donor transplantation, the impact on mortality is unknown. We performed a retrospective cohort study all adult who were listed initial...
We recently reported on a series of patients who experienced acute cellular rejection (ACR) during the treatment hepatitis C virus (HCV) infection in our posttransplantation cohort. Our hypothesis is that HCV clearance improves hepatic microsomal function, which turn results lower trough cyclosporine (CyA) and tacrolimus (TAC) levels, predisposing patient to ACR. Records all receiving transplants for at center from 1993 June 2002 were reviewed. Two hundred three identified. Thirty-seven...
As long-term survival after liver transplantation increases, metabolic complications are becoming increasingly prevalent. Given concerns about which group of providers should be managing recipients and how well managed, we administered a postal survey to 280 transplant hepatologists determine attitudes, perceptions, practice patterns in the management transplantation. The response rate was 68.2%. There great variation across United States with respect number posttransplant clinics, clinic...
INTRODUCTION: Primary sclerosing cholangitis (PSC) is a fibroinflammatory disease of the bile ducts leading to cirrhosis and hepatic decompensation. There are no approved pharmaceutical therapies for PSC. Berberine ursodeoxycholate (HTD1801) an ionic salt berberine ursodeoxycholic acid with pleiotropic mechanisms action. METHODS: An 18-week proof-of-concept study was conducted assess safety efficacy HTD1801 in This had three 6-week periods: (i) placebo-controlled period, (ii) treatment...
The impact of social determinants health on adult liver transplant recipient outcomes is not clear at a national level. Further understanding the patient can inform effective, equitable care delivery. Unadjusted and multivariable models were used to analyze Scientific Registry Transplant Recipients evaluate association between Social Deprivation Index (SDI) based recipient’s residential location graft survival. We included recipients January 1, 2008 December 2021. Patient survival lower in...