A5035435509- Gallbladder and Bile Duct Disorders
- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Pancreatitis Pathology and Treatment
- Liver Disease and Transplantation
- Pancreatic and Hepatic Oncology Research
- Inflammatory Bowel Disease
- Organ Transplantation Techniques and Outcomes
- Microscopic Colitis
- Diverticular Disease and Complications
- Gastric Cancer Management and Outcomes
- Biliary and Gastrointestinal Fistulas
- Gastrointestinal Bleeding Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Tumor Research and Treatment
- Gastroesophageal reflux and treatments
- Abdominal vascular conditions and treatments
- Diversity and Career in Medicine
- Clinical Nutrition and Gastroenterology
- Eosinophilic Esophagitis
University of California, Los Angeles
2008-2025
Olive View-UCLA Medical Center
2017-2025
Princess Alexandra Hospital
2024
Adventist Health Glendale
2023-2024
Los Angeles Medical Center
2018-2023
University of Toronto
2023
Harman (United Kingdom)
2022
University of Southern California
2022
Harbor–UCLA Medical Center
2022
UCLA Medical Center
2022
Emerging data suggest that oral antibiotics may have therapeutic effects in primary sclerosing cholangitis (PSC), but published studies are limited.To investigate the safety and efficacy of vancomycin metronidazole patients with PSC.Thirty-five PSC were randomised a double-blind manner into four groups: 125 mg or 250 times/day, 500 three times/day for 12 weeks. The endpoint was decrease alkaline phosphatase (ALK) at Secondary end points included serum bilirubin Mayo risk score; pruritus;...
Primary sclerosing cholangitis (PSC) is an incurable cholangiopathy of unknown etiopathogenesis. Here we tested the hypothesis that cholangiocyte senescence a pathophysiologically important phenotype in PSC. We assessed markers cellular and senescence-associated secretory (SASP) livers patients with PSC, primary biliary cirrhosis, hepatitis C, normals by fluorescent situ hybridization (FISH) immunofluorescence microscopy (IFM). whether endogenous exogenous constituents affect SASP cultured...
Primary sclerosing cholangitis (PSC) is a chronic, idiopathic, fibroinflammatory cholangiopathy. The role of the microbiota in PSC etiopathogenesis may be fundamentally important, yet remains obscure. We tested hypothesis that germ‐free (GF) mutltidrug resistance 2 knockout (mdr2 −/− ) mice develop distinct phenotype, compared to conventionally housed (CV) mdr2 mice. Mdr2 (n = 12) were rederived as GF by embryo transfer, maintained isolators, and sacrificed at 60 days parallel with...
WHAT'S NEW SINCE THE 2010 GUIDELINES? Inclusion of guidance for the diagnosis and management cholangiocarcinoma (CCA) in patients with without primary sclerosing cholangitis (PSC) (Figures 5, 8, 9). Introduction term relevant stricture, defined as any biliary stricture common hepatic duct or ducts associated signs symptoms obstructive cholestasis and/or bacterial (Table 1). In equivocal MRI cholangiopancreatography (MRI/MRCP) findings, a repeated high‐quality MRI/MRCP should be performed...
Journal Article Health-related quality of life in inflammatory bowel disease: Psychosocial, clinical, socioeconomic, and demographic predictors Get access Anilga Moradkhani, Moradkhani * a California School Professional Psychology, Alhambra, CA, USA *Corresponding author at: 1000 South Fremont Ave, Unit 5, CA 91308, USA. Tel.: + 1 818 378 1212; fax: 651 251 5111. E-mail address:[email protected] Search for other works by this on: Oxford Academic PubMed Google Scholar Linda J. Beckman,...
Primary sclerosing cholangitis (PSC) is a risk factor for cholangiocarcinoma (CCA) and gallbladder carcinoma (GBCa). Surveillance GBCa recommended, but the clinical utility of surveillance other hepatobiliary cancers (HBCa) in PSC, namely CCA hepatocellular (HCC), remains unclear. We aimed to determine whether associated with better survival after diagnosis HBCa patients PSC. Medical records PSC seen at Mayo Clinic Rochester from 1995 2015 were reviewed. Patients included if they had ≥1 year...
Primary sclerosing cholangitis (PSC) often coexists with inflammatory bowel disease (IBD) and can be complicated by cholangiocarcinoma (CCA), a lethal malignancy for which reliable predictors remain unknown. We aimed to characterize the influence of colectomy IBD duration on risk CCA in patients PSC-IBD.A retrospective review PSC-IBD seen at Mayo Clinic, Rochester, between January 2005 May 2013 was performed. The primary outcome time development our goal determine whether differed without...
Primary sclerosing cholangitis (PSC) is a rare, chronic, cholestatic liver disease in which emerging data suggest that oral antibiotics may offer therapeutic effects. We enrolled patients with PSC 12-week, open-label pilot study to investigate the efficacy and safety of 550 mg rifaximin twice daily. The primary end point was serum alkaline phosphatase (ALK) at 12 weeks. Secondary points included (1) bilirubin, gamma-glutamyl transpeptidase, Mayo risk score; (2) fatigue impact scale, chronic...
Hemobilia refers to bleeding from and/or into the biliary tract and is an uncommon but important cause of gastrointestinal hemorrhage. Reports hemobilia date back 1600s, due its relative rarity challenges in diagnosis, only recent decades has been more critically studied. The majority cases are iatrogenic caused by invasive procedures involving liver, pancreas, bile ducts hepatopancreatobiliary vasculature, with trauma malignancy representing two other leading causes. A classic triad right...