A5055765840- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- Viral-associated cancers and disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatitis C virus research
- Cytomegalovirus and herpesvirus research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Polyomavirus and related diseases
- Virus-based gene therapy research
- Organ and Tissue Transplantation Research
- Gallbladder and Bile Duct Disorders
- Xenotransplantation and immune response
- Genetic Associations and Epidemiology
- T-cell and B-cell Immunology
- Neonatal Health and Biochemistry
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
University of Pennsylvania
2016-2025
Hospital of the University of Pennsylvania
2015-2025
Penn Center for AIDS Research
2007-2024
Baylor University Medical Center
2023
Cleveland Clinic
2023
Northwestern Medicine
2023
University of Alabama at Birmingham
2023
Seoul National University
2023
Hôpital Paul-Brousse
2022
Children's Hospital of Philadelphia
1999-2021
Translational studies in liver transplantation often require an endpoint of graft function or dysfunction beyond loss. Prior definitions early allograft (EAD) vary, and none have been validated a large multicenter population the Model for End-Stage Liver Disease (MELD) era. We examined updated definition EAD to validate previously used criteria, correlated this with patient outcome. performed cohort study 300 deceased donor transplants at 3 U.S. programs. was defined as presence one more...
Viral persistence is associated with hierarchical antiviral CD8 T cell exhaustion increased programmed death-1 (PD-1) expression. In HCV persistence, HCV-specific cells from the liver (the site of viral replication) display PD-1 expression and a profound functional impairment that not reversed by blockade alone. Here, we report inhibitory receptor cytotoxic lymphocyte-associated antigen-4 (CTLA-4) preferentially upregulated in PD-1+ but blood chronically HCV-infected patients. PD-1/CTLA-4...
The objective of this study was to characterize the patient population with respect selection, assess surgical morbidity and graft failures, analyze contribution perioperative clinical factors recipient outcome in adult living donor liver transplantation (ALDLT).Previous reports have been center-specific or from large databases lacking detailed variables. Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL) represents first North American multicenter report risk aiming...
A wider application of living donor liver transplantation is limited by morbidity concerns. An observational cohort 760 donors accepted for surgery and enrolled in the Adult-to-Adult Living Donor Liver Transplantation study provides a comprehensive assessment incidence, severity natural history donation (LLD) complications. (assessed 29 specific complications), predictors, time from to complications complication onset resolution were measured outcomes over 12-year period. Out procedures, 20...
The role of chronic hepatitis C virus (HCV) in the pathogenesis HCV-associated hepatocellular carcinoma (HCC) remains controversial. To understand transition from benign to malignant, we studied gene expression patterns liver tissues at different stages, including normal, cirrhosis, and HCC stages. We 108 tissue samples obtained 88 distinct patients (41 HCV-cirrhotic tissues, 17 with HCC, 47 HCV-HCC tissues). Differentially expressed genes (DEG) were by use high-density oligonucleotide...
: This multicentric study of 17 high-volume centers presents 12 benchmark values for liver transplantation. Those values, mostly targeting markers morbidity, were gathered from 2024 "low risk" cases, and may serve as reference to assess outcome single or any groups patients.To propose in transplantation, serving assessing individual patients other patient groups.Best achievable results that is, benchmarks, are unknown. Consequently, comparisons within across over time remain speculative.Out...
To measure and define the best achievable outcome after major hepatectomy.No reference values are available on outcomes hepatectomies. Analysis in living liver donors, with safety as highest priority, offers opportunity to benchmarks possible results.Outcome analyses of 5202 hemi-hepatectomies from donors (LDs) 12 high-volume centers worldwide were performed for a 10-year period. Endpoints, calculated at discharge, 3 6 months postoperatively, included postoperative morbidity measured by...
To compare conventional low-temperature storage of transplant donor livers [static cold (SCS)] with the organs at physiological body temperature [normothermic machine perfusion (NMP)].
In Brief Objective: To determine whether patient and graft survival following transplantation with non-heart-beating donor (NHBD) hepatic allografts is equivalent to heart-beating-donor (HBD) allografts. Summary Background Data: With the growing disparity between number of patients awaiting liver a limited supply cadaveric organs, there renewed interest in use from NHBDs. Limited outcome data addressing this issue exist. Methods: Retrospective evaluation among adult recipients NHBD compared...
Background. Hepatic allografts from non–heart-beating donors (NHBD) have been cited as a means to expand the supply of donor livers. Concern exists that warm ischemic time in addition subsequent cold ischemia-reperfusion injury may result damage sensitive cell populations within liver. Because biliary epithelium is injury, authors surmised an increased incidence complications might occur among recipients NHBD allograft. Methods. This study was retrospective evaluation compared group...
Information regarding treatment of post-transplant lymphoproliferative disease (PTLD) beyond reduction in immunosuppression (RI) is limited. We retrospectively evaluated patients receiving rituximab and/or chemotherapy for PTLD response, time to failure (TTF) and overall survival (OS). Thirty-five met inclusion criteria. Twenty-two underwent treatment, with response rate (ORR) 68%. Median TTF was not reached at 19 months estimated OS 31 months. In univariable analysis, Epstein-Barr virus...
Improvements in human immunodeficiency virus (HIV)-associated mortality make it difficult to deny transplantation based upon futility. Outcomes the current management era are unknown. This is a prospective series of liver or kidney transplant recipients with stable HIV disease. Eleven and 18 were followed for median 3.4 years (IQR [interquartile range] 2.9-4.9). One- 3-year recipients' survival was 91% 64%, respectively; 94%. graft 82% 83%. Kidney patient similar general population, while...
Appropriate patient selection is crucial in ensuring acceptable outcomes from orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC). The United Network Organ Sharing (UNOS) has elected to prioritize HCC patients OLT based on criteria of tumor burden. However, it unclear whether these correlate with outcome, or the pathobiological features associated recurrence. Therefore, we analyzed 109 consecutive undergoing at our center, determine utility present predicting outcome....
Hepatitis C virus (HCV) is a controversial indication for liver transplantation (LT) in human immunodeficiency (HIV)-infected patients because of reportedly poor outcomes. This prospective, multicenter US cohort study compared patient and graft survival 89 HCV/HIV-coinfected 2 control groups: 235 HCV-monoinfected LT controls all transplant recipients who were 65 years old or older. The 3-year rates 60% [95% confidence interval (CI) = 47%-71%] 53% (95% CI 40%-64%) the HCV/HIV 79% 72%-84%) 74%...
Members of the Clinical Practice Committee, American Society Transplantation, have attempted to define referral criteria for solid organ transplantation. Work done by Committee does not represent official position Transplantation. Recipients transplantation are growing in numbers, progressively outstripping availability donors. As there may be discrepancies practice and, therefore, inequity exist terms access transplantation, needs uniformity about who should referred transplant centers so...
OBJECTIVES Biliary complications and their treatment in adult cadaveric liver transplantation (CLT) are well described. However, biliary management living donor (LDLT) not characterized. We assessed the role of endoscopic retrograde cholangiopancreatography (ERCP) diagnosis following LDLT. METHODS performed a retrospective cohort analysis all LDLT recipients with duct-to-duct anastomoses (n = 15). Specific data included referral for ERCP, diagnosis, therapy. Comparisons were made to 260 CLT...
Receipt of a living donor liver transplant (LDLT) has been associated with improved survival compared waiting for deceased (DDLT). However, the benefit questioned candidates Model Endstage Liver Disease (MELD) scores <15, and advantage LDLT not demonstrated during MELD allocation era, especially low patients. Transplant enrolled in Adult-to-Adult Living Donor Transplantation Cohort Study after February 28, 2002 were followed median 4.6 years. Starting at time presentation first potential...