A5010214504- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Hepatitis C virus research
- Fungal Biology and Applications
- Herpesvirus Infections and Treatments
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Immune cells in cancer
- Hepatitis B Virus Studies
- RNA modifications and cancer
- Toxin Mechanisms and Immunotoxins
- Animal Virus Infections Studies
- Food Quality and Safety Studies
- Ginseng Biological Effects and Applications
- Polysaccharides and Plant Cell Walls
- HIV Research and Treatment
- Pharmacological Effects of Natural Compounds
- Phytochemical compounds biological activities
- Viral gastroenteritis research and epidemiology
- Seaweed-derived Bioactive Compounds
- Tuberculosis Research and Epidemiology
- Flavonoids in Medical Research
- Probiotics and Fermented Foods
- Lymphoma Diagnosis and Treatment
Duksung Women's University
2015-2024
GTx (United States)
2020
Philadelphia VA Medical Center
2017
University of Pennsylvania
2009-2017
Rural Development Administration
2013
Kyungpook National University
2013
Texas A&M University System
2004-2010
Veterans Health Administration
2009
Yonsei University
2004
Viral persistence is associated with hierarchical antiviral CD8 T cell exhaustion increased programmed death-1 (PD-1) expression. In HCV persistence, HCV-specific cells from the liver (the site of viral replication) display PD-1 expression and a profound functional impairment that not reversed by blockade alone. Here, we report inhibitory receptor cytotoxic lymphocyte-associated antigen-4 (CTLA-4) preferentially upregulated in PD-1+ but blood chronically HCV-infected patients. PD-1/CTLA-4...
Interleukin (IL)-6 plays a crucial role in the progression, invasion, and metastasis of breast cancer. Triple-negative cancer (TNBC) cell line MDA-MB-231 is known for its aggressive metastasis. Epithelial to mesenchymal transition (EMT) critical process The positive correlation between IL-6 EMT tumor microenvironment reported. We found significantly upregulated expression cells. A blockade decreased levels phosphorylated signal transducer activator transcription 3 (pSTAT3),...
Epstein-Barr virus (EBV) is a human gamma-1 herpesvirus that establishes lifelong latency in over 90% of the world's population. During latency, exists predominantly as chromatin-associated, multicopy episome nuclei variety tumor cells derived from B cells, T natural killer (NK) and epithelial cells. Licorice root Glycyrrhiza uralensis or G. glabra has traditionally cultivated eastern part Asia. was reported to have anti-viral, anti-inflammatory, anti-atopic, hepatoprotective,...
Cordyceps species are known to produce numerous active components and used for diverse medicinal purposes because of their varied physiological activities, including ability protect the liver from damage as well anticancer, antidepressant, anti-inflammatory, hypoglycemic, antimicrobial effects.Cordycepin, an adenosine derivative, differs in that its ribose lacks oxygen atom at 3′ position.Several research groups have reported cordycepin has antiviral activity against several viruses...
Cordyceps militaris has been used as a traditional medicine in Asian countries for long time. Different types of extract were reported to have various pharmacological activities including an anti-cancer effect. We investigated the inhibitory effect ethanol on human colorectal cancer-derived cell line, RKO.RKO cells treated with concentrations nucleosides-enriched 48 h and cytotoxicity was measured using CCK-8 assay. Then, xenograft Balb/c nude mice injected RKO subsequently orally...
Licorice extracts have been widely used in herbal and folk medications. Glycyrrhiza contains diverse range of biological compounds including triterpenes (glycyrrhizin, glycyrrhizic acid) flavonoids (quercetin, liquiritin, liquiritigenin, glabridin, licoricidin, isoliquiritigenin). The licorice are known to strong anti-cancer activities. Quercetin, the most abundant flavonoid, has shown anti-ulcer, anti-cancer, antioxidant, anti-inflammatory properties. Latent Epstein-Barr virus (EBV)...
Human hepatocellular carcinoma (HCC) is the most common and even worse at prognosis. The patients with HCC which accompanied by other diseases, such as cirrhosis, can be limited in various treatments, chemotherapy, not without diseases. NLRP3 inflammasome plays an important role innate immune response, but emerging evidence has indicated that implicated all stages of cancer development. Various cells express protein through autocrine or paracrine signaling their environment, NK do not....
In this study, we examined the anti-tumor effects of heat-killed Bifidobacterium and Lactobacillus strains on human colorectal carcinoma RKO cells in vitro vivo xenograft models. First, cytotoxic apoptotic 11 different were using an MTT assay flow cytometry, respectively. Then, BALB/c nude mice implanted with orally administered single or mixed bacterial to examine their inhibitory tumor growth. Additionally, levels cleaved caspase-9, -3, -7 PARP tissues analyzed Western blotting...
Paraprobiotics, inactivated microbial cells, regulate immune system and exhibit antioxidant anti-inflammatory activities in patients with weakened immunity or the elderly. This study evaluated anti-tumor effects of heat-killed Bifidobacterium Lactobacillus on human gastric cancer MKN1 cells vitro vivo xenograft animal models. First, cytotoxicity apoptosis 11 different strains were examined using MTT assay flow cytometry, respectively. Then, BALB/c nude mice models implanted orally...
ABSTRACT Tumor necrosis factor alpha (TNF-α) plays an important role in the host immune response to infection with intracellular pathogen Mycobacterium tuberculosis . It is essential for formation of protective tuberculous granulomas and regulates expression other cytokines which contribute a response. Interleukin-12 (IL-12) known promote Th1 response, antimycobacterial resistance. Recombinant guinea pig TNF-α (rgpTNF-α) protein (17 kDa) was purified, its bioactivity confirmed by...
CCCTC-binding factor (CTCF) has been implicated in various aspects of viral and host chromatin organization transcriptional control. We showed previously that CTCF binds to a cluster three sites the first intron Kaposi's sarcoma-associated herpesvirus (KSHV) multicistronic latency-associated transcript encodes nuclear antigen (LANA), cyclin (vCyclin), vFLIP, microRNAs, kaposin. show here these binding regulate mRNA production, RNA polymerase II (RNAPII) programming, nucleosome KSHV latency...
Distinct viral gene expression characterizes Epstein-Barr virus (EBV) infection in EBV-producing marmoset B-cell (B95-8) and EBV-associated gastric carcinoma (SNU719) cell lines. CCCTC-binding factor (CTCF) is a structural chromatin that coordinates interactions the EBV genome. Chromatin immunoprecipitation followed by sequencing against CTCF revealed 16 binding sites B95-8 SNU719 genomes. The biological function of one site (S13 locus) located on Bam HI A right transcript (BART) miRNA...
Natural killer (NK) cell activity is more attenuated in hepatocellular carcinoma (HCC) patients than normal. Hypoxic-inducible factor (HIF)-1α highly expressed tumors to maintain their metabolism a hypoxic environment. The expression of HIF-1α cancers can lead growth, proliferation, invasion/metastasis and immune escape. Although apigenin, flavonoid, known have various biological activities, it has not been demonstrated NK HCC cells. In this study, NK-92 cells were directly cocultured with...
This study evaluates the immune-enhancing effects of
Abstract The CC chemokine ligand 5 (CCL5; regulated on activation, normal T expressed and secreted) is known to recruit activate leukocytes; however, its role in altering the responses of host cells a subsequent encounter with microbial pathogen has rarely been studied. Recombinant guinea pig (rgp)CCL5 was prepared, influence peritoneal alveolar macrophage activation examined by measuring cytokine mRNA expression stimulated rgpCCL5 alone or exposed prior lipopolysaccharide (LPS) stimulation....