A5023697227- Neuroblastoma Research and Treatments
- PARP inhibition in cancer therapy
- Neuroendocrine Tumor Research Advances
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Research Studies
- Cancer therapeutics and mechanisms
- Tourism, Volunteerism, and Development
- Aerospace and Aviation Technology
- Magnesium Oxide Properties and Applications
- Prostate Cancer Treatment and Research
- Surface Roughness and Optical Measurements
- Vehicular Ad Hoc Networks (VANETs)
- Concrete and Cement Materials Research
- Engineering Applied Research
- Internet of Things and Social Network Interactions
- Materials Engineering and Processing
- Diverse Topics in Contemporary Research
- Aeroelasticity and Vibration Control
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lymphatic System and Diseases
- Microfluidic and Bio-sensing Technologies
- Lung Cancer Diagnosis and Treatment
- Radiology practices and education
- Advancements in Photolithography Techniques
- Acute Myeloid Leukemia Research
Yonsei University
2011-2024
Severance Hospital
2024
Hospital of the University of Pennsylvania
2021-2024
Korea Research Institute of Standards and Science
2024
Seoul National University Hospital
2014-2024
University of Pennsylvania
2018-2024
Massachusetts General Hospital
2019-2024
Children's Hospital of Philadelphia
2023
Nikon (United States)
2021-2022
Ulsan National Institute of Science and Technology
2018-2021
The NMDAR plays a unique and vital role in subcellular signaling. Calcium influx initiates signaling cascades important for both synaptic plasticity survival; however, overactivation of the receptor leads to toxicity cell death. This dichotomy is partially explained by location receptor. NMDARs located at synapse stimulate survival pathways, while extrasynaptic receptors signal Thus far, this interplay between has been studied exclusively cortical (CTX) hippocampal neurons. It was unknown...
Alpha-emitters can be pharmacologically delivered for irradiation of single cancer cells, but cellular lethality could further enhanced by targeting alpha-emitters directly to the nucleus. PARP-1 is a druggable protein in nucleus that overexpressed neuroblastoma compared with normal tissues and associated decreased survival high-risk patients. To exploit this, we have functionalized PARP inhibitor (PARPi) an alpha-emitter astatine-211. This approach offers cytotoxicity from conventional...
Licorice extracts have been widely used in herbal and folk medications. Glycyrrhiza contains diverse range of biological compounds including triterpenes (glycyrrhizin, glycyrrhizic acid) flavonoids (quercetin, liquiritin, liquiritigenin, glabridin, licoricidin, isoliquiritigenin). The licorice are known to strong anti-cancer activities. Quercetin, the most abundant flavonoid, has shown anti-ulcer, anti-cancer, antioxidant, anti-inflammatory properties. Latent Epstein-Barr virus (EBV)...
The currently available therapeutic radiopharmaceutical for high-risk neuroblastoma, <sup>131</sup>I-metaiodobenzylguanidine, is ineffective at targeting micrometastases because of the low–linear-energy-transfer (LET) properties high-energy β-particles. In contrast, Auger radiation has high-LET with nanometer ranges in tissue, efficiently causing DNA damage when emitted near DNA. aim this study was to evaluate cytotoxicity targeted therapy preclinical models neuroblastoma. <b>Methods:</b> We...
Obesity and type 2 diabetes (T2D) are major risk factors for cardiovascular (CV) diseases. Dysregulated pro-apoptotic ceramide synthesis reduces β-cell insulin secretion, thereby promoting hyperglycaemic states that may manifest as T2D. Pro-apoptotic ceramides modulate sensitivity glucose tolerance while being linked to poor CV outcomes. Sirtuin-1 (SIRT1) is a NAD + -dependent deacetylase protects against pancreatic dysfunction; however, systemic levels decreased in obese-T2D mice promote...
Sensor technologies have been actively employed in structural health monitoring (SHM) to evaluate safety. To provide stable and real-time monitoring, a practical wireless sensor network system (WSNS) based on vibrating wire strain gauges (VWSGs) is proposed applied building under construction. In this WSNS, the data measured from each VWSG are transmitted node via signal line then master through short-range communication module (operating Industrial, Scientific, Medical (ISM) band). The also...
A reliability modeling solution including endurance and data retention is developed for NAND Floating Gate Flash memory. Endurance model with trap generation considers the tunneling oxide quality distribution process effect. Electric field current effect also have been included. The complicated on threshold voltage Swing shift well explained based non-uniformly trapped charge distribution. Thermal emission Poole-Frenkel from to substrate are included simulation. Dominant mechanisms under...
Theranostics are emerging as a pillar of cancer therapy that enable the use single molecule constructs for diagnostic and therapeutic application. As poly adenosine diphosphate (ADP)-ribose polymerase 1 (PARP-1) is overexpressed in various types, localized to nucleus, PARP-1 can be safely targeted with Auger emitters induce DNA damage tumors. Here, we investigated radioiodinated PARP inhibitor, [125I]KX1, show drug target specific subsequent killing BRCA1 non-BRCA mutant ovarian cells at...
Emerging studies suggested that murine podoplanin-positive monocytes (PPMs) are involved in lymphangiogenesis. The goal of this study was to demonstrate the therapeutic lymphangiogenesis human PPMs by interaction with platelets. Aggregation culture peripheral blood mononuclear cells (PBMCs) resulted cellular aggregates termed hematospheres. During 5-day culture, expanded exponentially and expressed several lymphatic endothelial cell–specific markers including vascular growth factor receptor...
Abstract Background Somatostatin analogs (SSAs) are the frontline antitumor therapy in advanced well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs). A subset of patients demonstrate early disease progression on SSA therapy, yet currently known predictors for treatment failure lack specificity to affect therapeutic decision. SSAs target tumor somatostatin receptors, level which can be quantitatively assessed with 68Ga-DOTATATE positron emission tomography-computed...
Peptide receptor radionuclide therapy (PRRT) is approved in the US for treatment of gastroenteropancreatic neuroendocrine tumors (NETs), but data on PRRT outcomes within populations remain scarce.To analyze first 2 years implementation at a US-based NET referral center.This cohort study was conducted using medical records patients with metastatic receiving from 2018 through 2020 program tertiary center. Included were those center NETs who received least 1 dose over period. Laboratory toxic...
Radionuclide therapy targeting prostate-specific membrane antigen (PSMA) with alpha-emitting 225Ac-PSMA-617 has shown clinical efficacy even in cases of failed beta-emitting 177Lu-PSMA-617. We investigated the relative to 177Lu-PSMA-617 using subcellular dosimetry.A 3-dimensional model prostate cancer was constructed. For each decay, absorbed and equivalent radiation dose cell nuclei calculated. The per administered activity calculated by taking into account differences residence time tumor...
Abstract Astatine-211-parthanatine ([ 211 At]PTT) is an alpha-emitting radiopharmaceutical therapeutic that targets poly(adenosine-diphosphate-ribose) polymerase 1 (PARP1) in cancer cells. High-risk neuroblastomas exhibit among the highest PARP1 expression across solid tumors. In this study, we evaluated efficacy of [ At]PTT using 11 patient-derived xenograft (PDX) mouse models high-risk neuroblastoma, and assessed hematological marrow toxicity a CB57/BL6 healthy model. We observed broad PDX...
In this study the full-scale operation of soil flushing with air sparging to improve removal efficiency petroleum at depths less than 7 m a military site in Korea was evaluated. The target area polluted by multiple gasoline and diesel fuel sources. composed heterogeneous layers granules, sand, silt clay. factors were systemically assessed using column test pilot before running process site. discharged TPH BTEX (benzene, toluene, ethylbenzene, xylenes) concentrations water highest 20 min rate...