A5084770573- Tissue Engineering and Regenerative Medicine
- Pluripotent Stem Cells Research
- Adipokines, Inflammation, and Metabolic Diseases
- CRISPR and Genetic Engineering
- Fluid Dynamics and Thin Films
- Nanomaterials and Printing Technologies
- Adipose Tissue and Metabolism
- Surface Modification and Superhydrophobicity
- Congenital heart defects research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiomyopathy and Myosin Studies
- Dietary Effects on Health
- Signaling Pathways in Disease
- Heat Transfer and Optimization
- Fluid Dynamics Simulations and Interactions
- Mitochondrial Function and Pathology
- Fluid Dynamics and Heat Transfer
- Nuclear Receptors and Signaling
- Advanced Thermoelectric Materials and Devices
- Gas Dynamics and Kinetic Theory
- Cardiac Fibrosis and Remodeling
- Lymphatic Disorders and Treatments
- Sexual function and dysfunction studies
- nanoparticles nucleation surface interactions
- Caveolin-1 and cellular processes
Seoul National University Hospital
2014-2024
Seoul National University
2012-2022
New York University Press
2019
Cornell University
2019
Harvard University Press
2019
Cambridge University Press
2019
Chitose Institute of Science and Technology
2019
Abstract Sildenafil is known to reduce cardiac hypertrophy through cGMP-dependent protein kinase (cGK) activation. Studies have demonstrated that cGK has a central switching role in modulating vascular smooth muscle cell (VSMC) phenotype response injury. Here, we aimed examine the effects of activation by sildenafil on neointimal formation and platelet aggregation. After injury, hyperplasia rat carotid arteries was significantly reduced sildenafil-treated group. This effect accompanied...
Emerging studies suggested that murine podoplanin-positive monocytes (PPMs) are involved in lymphangiogenesis. The goal of this study was to demonstrate the therapeutic lymphangiogenesis human PPMs by interaction with platelets. Aggregation culture peripheral blood mononuclear cells (PBMCs) resulted cellular aggregates termed hematospheres. During 5-day culture, expanded exponentially and expressed several lymphatic endothelial cell–specific markers including vascular growth factor receptor...
Resistin plays an important role in the pathophysiology of obesity-mediated insulin resistance mice. However, biology resistin humans is quite different from that rodents. Therefore, association between and remains unclear humans. Here, we tested whether how endocannabinoid system (ECS) control circulating peripheral blood mononuclear cells (PBMCs) produce infiltrate into adipose tissue, heart, skeletal muscle, liver, resulting inflammation resistance. Using human PBMCs, investigate ECS...
Liquid films on wettable solid surfaces can be disturbed to dewet when low surface tension liquids or surfactants are added because the difference gives rise stresses film interface. Here we consider an alcohol drop placed above a thin aqueous film, which punctures hole in starting from underneath drop. Such dewetting is attributed Marangoni effects caused by spatial gradient of vapour concentration. We measure liquid–gas interfacial rapidly responding surrounding isopropyl concentration,...
In patients with Parkinson's disease (PD), stem cells can serve as therapeutic agents to restore or regenerate injured nervous system. Here, we differentiated two types of cells; mouse embryonic (mESCs) and protein-based iPS (P-iPSCs) generated by non-viral methods, into midbrain dopaminergic (mDA) neurons, then compared the efficiency DA neuron differentiation from these cell types. undifferentiated stage, P-iPSCs expressed pluripotency markers ES did, indicating that reprogramming was...
Films and drops of liquids can change their shapes move under the spatial gradient surface tension. A remote volatile liquid relatively low tension induce such flows because its vapor locally lowers films drops. Here, we show that aqueous thicker than approximately 100 µm be punctured to immediately expose a dry hole by an overhanging isopropyl alcohol drop, which is attributed vapor-mediated Marangoni effect. We construct corroborate scaling laws predict film dynamics, considering balance...
Abstract Background Although vasospastic angina (VSA) is known to be caused by coronary artery spasm, no study has fully elucidated the exact underlying mechanism. Moreover, in order confirm VSA, patients should undergo invasive angiography with spasm provocation test. Herein, we investigated pathophysiology of VSA using peripheral blood-derived induced pluripotent stem cells (iPSCs) and developed an ex vivo diagnostic method for VSA. Methods results With 10 mL blood from generated iPSCs...
Abstract
Тhe most pressing issue in generating induced pluripotent stem cells (iPSCs) clinical practice is the cell source. Compared to human dermal fibroblasts (HDFs), which have been widely used, peripheral blood could be a more easily obtainable alternative. However, iPSCs generated from fresh require inconvenient specific methods including isolation. Recently, we succeeded isolating and culturing heart-derived circulating called multipotent (CiMS) cells. Here, investigated generation efficiency...
Introduction: Adenylyl cyclase-associated protein1 (CAP1) is a functional receptor of human adipokine resistin and mediates inflammatory actions monocytes which expected to be link between chronic inflammation cardiometabolic disease such as obesity atherosclerosis. Although our recent investigation revealed CAP1 its signaling pathway in monocytes, the precise molecular mechanisms adenylyl cyclase that initiate resistin’s action have not been clarified yet. Also, roles endothelial cells...
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