A5100324400- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Stress Responses and Cortisol
- Bone Metabolism and Diseases
- Parkinson's Disease Mechanisms and Treatments
- Neuroendocrine regulation and behavior
- Nuclear Receptors and Signaling
- Bone health and osteoporosis research
- Birth, Development, and Health
- Bipolar Disorder and Treatment
- Bone health and treatments
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Treatment of Major Depression
- Neurotransmitter Receptor Influence on Behavior
- Biomarkers in Disease Mechanisms
- Alzheimer's disease research and treatments
- Health and Wellbeing Research
- Animal Behavior and Welfare Studies
- Pharmacological Receptor Mechanisms and Effects
- Biochemical effects in animals
- Nutrition, Health and Food Behavior
- Memory and Neural Mechanisms
Inje University
2015-2025
Inje University Busan Paik Hospital
2014-2025
Center for Clinical Research (United States)
2010-2024
Convergence
2024
Inje University Haeundae Paik Hospital
2021
Queen's University
2013
Sungkyunkwan University
2009
Pusan National University
2006
Hallym University
1999-2006
Kyonggi University
1999
Recent studies suggest that ketamine produces antidepressant actions via stimulation of mammalian target rapamycin (mTOR), leading to increased levels synaptic proteins in the prefrontal cortex. Thus, mTOR activation may be related action. However, signalling underlying drug action has not been well investigated. The aim present study was determine whether alterations were observed following treatment with drugs, using as a positive control. Using Western blotting, we measured changes...
The primary purpose of this study was to investigate the differences in serum brain-derived neurotrophic factor (BDNF) level between elderly Korean people over 65 years with and without dementia.171 individuals were enrolled study. Screening for cognitive impairments carried out using Mini-Mental Status Examination-Korean version (MMSE-KC). One hundred thirty-two subjects scored below 1.5 standard deviations (SD) mean MMSE-KC score, these evaluated Consortium Establish a Registry Alzheimer's...
Melatonin is a hormone that secreted by the pineal gland. To date, melatonin known to regulate sleep cycle controlling circadian rhythm. However, recent advances in neuroscience and molecular biology have led discovery of new actions effects melatonin. In studies, was shown antioxidant activity and, possibly, affect development Alzheimer's disease (AD). addition, has neuroprotective affects neuroplasticity, thus indicating potential antidepressant properties. present review, functions are...
Summary Objective Osteoporosis is a growing health problem in males as well females. Sex hormones and insulin‐like growth factor‐I (IGF‐I) have been shown to be the major determinants male bone metabolism. Osteoprotegerin (OPG) recently identified cytokine that acts decoy receptor for activator of NF‐κB ligand (RANKL). OPG RANKL important regulators osteoclastogenesis. However, relationship between OPG‐RANKL system status human populations are unclear. Thus, aim this study was investigate...
Recent evidence has suggested that atypical antipsychotic drugs regulate synaptic plasticity. We investigated whether some (olanzapine, aripiprazole, quetiapine, and ziprasidone) altered the expression of synapse‐associated proteins in rat hippocampal neuronal cultures under toxic conditions induced by B27 deprivation. A typical antipsychotic, haloperidol, was used for comparison. measured changes various including postsynaptic density protein‐95 (PSD‐95), brain‐derived neurotrophic factor...
Mi Kyoung Seo, Sehoon Jeong, Woo Seok Cheon, Dong Yun Lee, Sumin Gyu-Hui Deok-Gyeong Kang, Dae-Hyun Seog, Seong-Ho Kim, Jung Goo Sung Park. Clin Psychopharmacol Neurosci -0001;0:. https://doi.org/10.9758/cpn.25.1269
The aim of this study was to investigate the effects antidepressant tianeptine on mechanistic target rapamycin complex 1(mTORC1)-mediated autophagy pathway in primary hippocampal neurons exposed B27-deprived conditions. When were treated with at doses 1, 10, 50, and 100 µM for 3 days under conditions, we observed that it activated increased formation autophagosomes through upregulation autophagic proteins, including autophagy-activating kinase 1 (ULK1), Beclin LC3B-II/I, p62. And a...
Objective To investigate the effects of memantine, an N-methyl-d-aspartate (NMDA) receptor antagonist, on cognitive impairments in patients with chronic schizophrenia. Methods A 12-week, placebo-controlled trial was conducted to determine effectiveness memantine as adjunctive treatment conventional antipsychotic medications 26 The subjects were evaluated Korean version Mini-Mental State Examination (K-MMSE), Positive and Negative Syndrome Scale (PANSS), Hamilton Rating for Depression...
Early life stress can induce epigenetic changes through genetic and environmental interactions is a risk factor for depression. Brain-derived neurotrophic (BDNF) has been implicated in the pathophysiology of depression antidepressant drug action. We investigated at BDNF exon I promoter hippocampus adult rats subjected to maternal separation (MS) during early treated with an as adults.Rat pups were MS from postnatal day 1 21 received chronic escitalopram (ESC) adults. assessed effects ESC on...
Recent studies have suggested that the activation of mammalian target rapamycin (mTOR) signaling may be related to antidepressant action. Therefore, present study evaluated whether drugs would exert differential effects on mTOR in rat hippocampus under conditions chronic restraint stress. Male Sprague–Dawley rats were subjected stress for 6 h/days 21 days with either escitalopram (10 mg/kg) or paroxetine administered after procedure. Western blot analyses used assess changes levels...
Background . Leucine‐rich repeat kinase 2 (LRRK2) plays a critical role in the pathogenesis of Parkinson’s disease (PD). Aging is most risk factor for progression PD. The correlation between aging and cellular senescence has been established. Cellular correlated with dysregulation proteolytic pathway mitochondrial dysfunction, which are also associated aggregation α ‐synuclein ( ‐syn). Methods Human dopaminergic neuron‐like cells (differentiated SH‐SY5Y cells) were treated rotenone presence...
This study aimed to assess the efficacy of aripiprazole for management cognitive impairments and hyperprolactinemia in patients with schizophrenia on a stable dose risperidone.Thirty-five subjects stabilized risperidone (3-6 mg/day) minimum 3 months were enrolled double-blind, placebo-controlled phase 12 weeks an open-label another weeks. Subjects randomly assigned receive 10 mg/day (n=17) or placebo (n=18). Over following weeks, group received flexible while tapering risperidone. At...