A5014105445- Drug Transport and Resistance Mechanisms
- Pharmacogenetics and Drug Metabolism
- Natural Antidiabetic Agents Studies
- Antibiotics Pharmacokinetics and Efficacy
- Amino Acid Enzymes and Metabolism
- Ocular Infections and Treatments
- PARP inhibition in cancer therapy
- Chemical Synthesis and Analysis
- Amyotrophic Lateral Sclerosis Research
- Chronic Myeloid Leukemia Treatments
- Cancer therapeutics and mechanisms
- biodegradable polymer synthesis and properties
- Chemotherapy-induced organ toxicity mitigation
- Bioactive natural compounds
- Chemical Reaction Mechanisms
- 3D Printing in Biomedical Research
- Quinazolinone synthesis and applications
- Glaucoma and retinal disorders
- Intraperitoneal and Appendiceal Malignancies
- Parkinson's Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
- Neuroscience and Neuropharmacology Research
- Renal Transplantation Outcomes and Treatments
- Innovative Microfluidic and Catalytic Techniques Innovation
- Intraocular Surgery and Lenses
Chong Kun Dang Bio (South Korea)
2024
Korea Research Institute of Bioscience and Biotechnology
2020-2023
Seoul National University
2017-2020
Yonsei University
2015
Tokushima University
2010
Japan Science and Technology Agency
2010
Baylor College of Medicine
2008
Directed differentiation of hPSCs and transition from 3D intestinal organoids into functional hIECs.
A macrocyclic peptide scaffold with well-established structure-property relationship is desirable for tackling undruggable targets. Here, we adopted a natural macrocycle, cyclosporin O (
Enavogliflozin is a sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor approved for clinical use in South Korea. As SGLT2 inhibitors are treatment option patients with diabetes, enavogliflozin expected to be prescribed various populations. Physiologically based pharmacokinetic (PBPK) modelling can rationally predict the concentration-time profiles under altered physiological conditions. In previous studies, one of metabolites (M1) appeared have metabolic ratio between 0.20 and 0.25....
d-Amino acid oxidase (DAO) is a flavoenzyme that exists in the kidney, liver and brain of mammals. This enzyme catalyzes oxidation d-amino acids to corresponding α-keto acid, hydrogen peroxide ammonia. Recently d-serine, one substrates DAO, has been found mammalian brain, shown be co-agonist N-methyl-d-aspartate (NMDA) receptor glutamate neurotransmission. In this study, we investigated metabolism extracellular d-serine effects metabolites study pathophysiological role DAO. Treatment with...
The potential inhibitory effect of quercetin, a major plant flavonol, on breast cancer resistance protein (BCRP) activity was investigated in this study. presence quercetin significantly increased the cellular accumulation and associated cytotoxicity BCRP substrate mitoxantrone human cervical cells (HeLa cells) concentration-dependent manner. transcellular efflux prazosin, stereotypical substrate, also reduced bidirectional transport assay using BCRP-overexpressing cells; further kinetic...
Olaparib is a first-in-class poly (ADP-ribose) polymerase oral inhibitor used to treat various tumors. In this study, we clarified the roles of ABCB1/Abcb1 and ABCG2/Abcg2 transporters in restricting olaparib distribution brain. was efficiently transported by human ABCG2, ABCB1, mouse Abcg2 vitro. vivo disposition study using single or combination knockout mice, systemic exposure did not differ significantly between strains over an 8-h period. However, brain-to-plasma unbound concentration...
Purpose: Maltol (3-hydroxy-2-methyl-4-pyrone), formed by the thermal degradation of starch, is found in coffee, caramelized foods, and Korean ginseng root.This study investigated whether maltol could rescue neuroretinal cells from oxidative injury vitro.Methods: R28 cells, which are rat embryonic precursor were exposed to hydrogen peroxide (H 2 O , 0.0 1.5 mM) as an stress with or without (0.0 1.0 mM).Cell viability was monitored lactate dehydrogenase assay apoptosis examined terminal...
Endogenous canine ATP binding cassette B1 (cABCB1) is expressed abundantly in Madin-Darby kidney type II (MDCKII) cells, and its presence often complicates phenotyping of the transport process. Errors estimating corrected efflux ratio (cER), as a result variable expression cABCB1, were examined for dual substrates ABCB1 ABCG2 MDCKII cells expressing human (hABCG2). cABCB1 mRNA protein was 60% 55% lower, respectively, hABCG2 compared with wild type, suggesting that endogenous became after...
Abstract Larotrectinib is an orally administered drug and the first only selective pan-tropomyosin receptor kinase (TRK) inhibitor in clinical development to treat cancer patients harboring a neurotrophic tyrosine gene fusion. In this study, analytical method quantify TRK mouse human plasma was developed validated using LC-MS/MS following protein precipitation with acetonitrile. internal standard (carbamazepine) were separated from endogenous substances Xterra C18 column acetonitrile...
Supinoxin is a novel anticancer drug candidate targeting the Y593 phospho-p68 RNA helicase, by exhibiting antiproliferative activity and/or suppression of tumor growth. This study aimed to characterize in vitro and vivo pharmacokinetics supinoxin attempt physiologically based pharmacokinetic (PBPK) modeling rats. has good permeability, comparable that metoprolol (high permeability compound) Caco-2 cells, with negligible net absorptive or secretory transport observed. After an intravenous...
We evaluated the pharmacokinetics, tissue concentrations, and toxicities of belotecan during rotational intraperitoneal pressurized aerosol chemotherapy (RIPAC) in pigs.
Abstract Objectives To study the functional consequences of human and rat forms OCT2 in presence phenothiazines. Methods MDCK cells expressing or were established, MPP+ transport was determined by uptake assays. Concentration dependency studied for stimulatory/inhibitory effects phenothiazines on transport. Key findings Among 11 examined, majority found to have comparable transporter function between orthologous forms, while three phenothiazines, particularly mesoridazine, had complex...