A5030634151- Boron Compounds in Chemistry
- Nuclear Physics and Applications
- Marine Sponges and Natural Products
- Amino Acid Enzymes and Metabolism
- Reproductive tract infections research
- Radiation Therapy and Dosimetry
- Synthetic Organic Chemistry Methods
- Radiopharmaceutical Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Muscle Physiology and Disorders
- Boron and Carbon Nanomaterials Research
- Tissue Engineering and Regenerative Medicine
- Neuroinflammation and Neurodegeneration Mechanisms
- Medical Imaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Polyamine Metabolism and Applications
- Nerve injury and regeneration
- Machine Learning in Materials Science
- Metabolism and Genetic Disorders
- Meningioma and schwannoma management
- Rheumatoid Arthritis Research and Therapies
- Synthesis and Biological Activity
- T-cell and B-cell Immunology
Kyoto University Hospital
2024
Walter de Gruyter (Germany)
2020-2023
San Francisco State University
2020-2023
Santa Cruz County Office of Education
2020-2023
Saitama Medical University
2022
Kawasaki Medical School
2020-2022
Takeda (Japan)
2017-2021
Tokushima University
1993-2021
Translational Research Platform for Veterinary Biologicals (India)
2020
Osaka Medical and Pharmaceutical University
2018
SUMOylation is a reversible post-translational modification that regulates protein function through covalent attachment of small ubiquitin-like modifier (SUMO) proteins. The process SUMOylating proteins involves an enzymatic cascade, the first step which entails activation SUMO ATP-dependent catalyzed by SUMO-activating enzyme (SAE). Here, we describe identification TAK-981, mechanism-based inhibitor SAE forms SUMO–TAK-981 adduct as inhibitory species within catalytic site. Optimization...
A key intermediate in the first asymmetric synthesis of marine alkaloid (−)-nakadomarin (1), isolated from sponge Amphimedon sp., was optically active hydroisoquinoline 2. Two separate ring-closing-metathesis reactions were crucial to construction 15- and 8-membered rings.
D-Amino acid oxidase (DAO) has been established to be involved in the oxidation of D-serine, an allosteric activator N-methyl-D-aspartate-type glutamate receptor brain, and associated with onset schizophrenia. The effect risperidone, a benzisoxazole derivative, atypical antischizophrenic drug, on activity human DAO was tested using in-vitro oxygraph system rat C6, stable C6 transformant cells overexpressing mouse (designated as C6/DAO) pig kidney epithelial (LLC-PK 1 ). Risperidone...
Journal Article Potential Role for Astroglial d-Amino Acid Oxidase in Extracellular d-Serine Metabolism and Cytotoxicity Get access Hwan Ki Park, Park Department of Gene Regulatorics, The Institute Enzyme Research, University Tokushima, Tokushima 770-8503 ‡To whom correspondence should be addressed. Tel: +81-88-633-7430, Fax: +81-88-633-7431, E-mail: kiyo@ier.tokushima-u.ac.jp Search other works by this author on: Oxford Academic PubMed Google Scholar Yuji Shishido, Shishido Sayaka...
Deoxyhypusine synthase (DHPS) utilizes spermidine and NAD as cofactors to incorporate a hypusine modification into the eukaryotic translation initiation factor 5A (eIF5A). Hypusine is essential for eIF5A activation, which, in turn, plays key role regulating protein of selected mRNA that are associated with synthesis oncoproteins, thereby enhancing tumor cell proliferation. Therefore, inhibition DHPS promising therapeutic option treatment cancer. To discover novel lead compounds target DHPS,...
We demonstrate in the B16 melanoma (C57BL/6 derived) system that soluble form of tumor Ag preferentially suppresses immune responses 1) by inhibiting CTL activity effector phase and 2) induction specific Ts block generation phase. Soluble antigen injected i.p. into tumor-bearing host can effectively augment growth vivo. Two T cell types with L3T4+ or double-negative/I-J+ phenotype are involved suppression anti-melanoma easily be generated vitro primary 12 h-culture. Anti-melanoma recognizes...
D-Amino acid oxidase (DAO), a potential risk factor for schizophrenia, has been proposed to be involved in the decreased glutamatergic neurotransmission schizophrenia. Here we show inhibitory effect of an antipsychotic drug, chlorpromazine, on human DAO, which is consistent with previous reports using porcine although DAO was inhibited lesser degree (Ki = 0.7 mM) than DAO. Since chlorpromazine known induce phototoxic or photoallergic reactions and also transformed into various metabolites,...
d-Amino acid oxidase (DAO) is a flavoenzyme that exists in the kidney, liver and brain of mammals. This enzyme catalyzes oxidation d-amino acids to corresponding α-keto acid, hydrogen peroxide ammonia. Recently d-serine, one substrates DAO, has been found mammalian brain, shown be co-agonist N-methyl-d-aspartate (NMDA) receptor glutamate neurotransmission. In this study, we investigated metabolism extracellular d-serine effects metabolites study pathophysiological role DAO. Treatment with...
To obtain basic knowledge for the application of xenogeneic neural transplantation to patients with Parkinson's disease, rejection process grafts in rats was examined and a therapy control it developed. Tissues including ventral mesencephalon were taken from mouse embryos transplanted into right lateral ventricle mature male rats. Transplanted xenografts usually rejected by day 15. prevent graft rejection, host treated anti-T-cell receptor αβ (anti-TCRαβ) or anti-CD2 monoclonal antibody...
Understanding the biological effects of neutron mixed-beam irradiation used for boron capture therapy (BNCT) is important in order to improve efficacy and reduce side effects. In present study, cell viability DNA double-strand breaks (DNA-DSBs) were examined Chinese hamster ovary cells (CHO-K1) their radiosensitive mutant (xrs5, Ku80-deficient), following BNCT. Cell was significantly impaired groups compared reference gamma-ray group. The relative effectiveness 10% survival 3.3 1.2 CHO-K1...
The real-time detection of epithermal neutrons forms an important aspect boron neutron capture therapy. In this context, we developed detector based on the combination a small Eu:LiCaAlF6 scintillator and quartz fiber in order to fulfill irradiation-field requirements for irradiation test is performed with use reactor-based source. thermal sensitivities our are estimated be 9.52 × 10−8 ± 1.59 cm2 1.20 10−6 8.96 10−9 cm2, respectively. We also subject actual fields, confirm that flux can...
We describe a new modality for administering aminoglycosides to hemodialysis (HD) patients, namely, modification of the once-daily regimen which consists over 60 min by drip infusion just before each HD session, with preplanned peak concentration being reached at beginning session and then rapidly decreasing achieved start HD. The area under concentration-time curve (AUC), i.e., accumulation drug in body, is thus minimized this modality. Arbekacin (ABK) was given dose 2 mg/kg body weight 10...