A5033854234- Parasitic infections in humans and animals
- Parasitic Infections and Diagnostics
- Congenital Anomalies and Fetal Surgery
- Toxoplasma gondii Research Studies
- Chemokine receptors and signaling
- T-cell and B-cell Immunology
- Neuroinflammation and Neurodegeneration Mechanisms
- Bacteriophages and microbial interactions
- Heat shock proteins research
- Immunotherapy and Immune Responses
- Genetic and phenotypic traits in livestock
- HIV Research and Treatment
- Immune cells in cancer
- S100 Proteins and Annexins
- Pneumocystis jirovecii pneumonia detection and treatment
- Phenothiazines and Benzothiazines Synthesis and Activities
- Evaluation Methods in Various Fields
- RNA Interference and Gene Delivery
- Genomics and Phylogenetic Studies
- Immune Cell Function and Interaction
- Genetic Mapping and Diversity in Plants and Animals
- Crystallization and Solubility Studies
- Stroke Rehabilitation and Recovery
- Acute Ischemic Stroke Management
- 3D Printing in Biomedical Research
Zhengzhou University
2010-2025
Ningxia Medical University
2013-2025
Jiangsu University
2009-2025
Guangxi University
2024
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2024
Takeda (United States)
2018-2024
Huashan Hospital
2023-2024
Fudan University
2023-2024
State Key Laboratory of Medical Neurobiology
2023-2024
Hebei Science and Technology Department
2020-2024
High circulating levels of lactate and high mobility group box-1 (HMGB1) are associated with the severity mortality sepsis. However, it is unclear whether could promote HMGB1 release during The present study demonstrated a novel role in lactylation acetylation macrophages polymicrobial We found that can uptake extracellular via monocarboxylate transporters (MCTs) to p300/CBP-dependent mechanism. also observed stimulates by Hippo/YAP-mediated suppression deacetylase SIRT1 β-arrestin2-mediated...
SUMOylation is a reversible post-translational modification that regulates protein function through covalent attachment of small ubiquitin-like modifier (SUMO) proteins. The process SUMOylating proteins involves an enzymatic cascade, the first step which entails activation SUMO ATP-dependent catalyzed by SUMO-activating enzyme (SAE). Here, we describe identification TAK-981, mechanism-based inhibitor SAE forms SUMO–TAK-981 adduct as inhibitory species within catalytic site. Optimization...
Circulating lactate levels are a critical biomarker for sepsis and positively correlated with sepsis-associated mortality. We investigated whether plays biological role in causing endothelial barrier dysfunction sepsis. showed that causes vascular permeability worsens organ CLP Mechanistically, induces ERK-dependent activation of calpain1/2 VE-cadherin proteolytic cleavage, leading to the enhanced endocytosis cells. In addition, we found ERK2 interacts stabilizes complex resting...
The accumulation of self-renewed polarized microglia in the penumbra is a critical neuroinflammatory process after ischemic stroke, leading to secondary demyelination and neuronal loss. Although known regulate tumor cell proliferation neuroinflammation, HDAC3's role microgliosis microglial polarization remains unclear. We demonstrated that HDAC3 knockout (HDAC3-miKO) ameliorated poststroke long-term functional histological outcomes. RNA-seq analysis revealed mitosis as primary affected...
Abstract Citric acid gives lemons their unique flavor, which impacts sensory traits and market value. However, the intricate process of citric accumulation during lemon fruit growth remains incompletely understood. Here, we achieved a chromosomal-level genome assembly for ‘Xiangshui’ variety, spanning 364.85 Mb across nine chromosomes. This revealed 27 945 genes 51.37% repetitive sequences, tracing divergence from citron 2.85 million years ago. DNA methylome analysis fruits different...
We recently described a strategy for intracellular delivery of macromolecules, utilizing pH-responsive "core-shell" structured gel particles. These cross-linked hydrogel particles disrupt endosomes with low toxicity by virtue physical sequestration an endosome-disrupting "proton sponge" core inside nontoxic hydrophilic shell. Here we tested the efficacy this system cytosolic broad range macromolecular cargos, and demonstrate proteins, whole viral particles, or siRNA oligonucleotides into...
Abstract Aims Inadequate healing after myocardial infarction (MI) leads to heart failure and fatal ventricular rupture, while optimal requires timely induction resolution of inflammation. This study tested the hypothesis that heat shock protein B1 (HSPB1), which limits inflammation during endotoxemia, modulates wound MI. Methods results To test this hypothesis, cardiomyocyte-specific HSPB1 knockout (Hspb1−/−) mice were generated using Cre-LoxP recombination system. MI was induced by ligation...
Abstract Endothelial damage is a critical mediator of myocardial ischemia/reperfusion (I/R) injury. HSPA12B an endothelial-cell-specifically expressed heat shock protein. However, the roles in acute I/R injury unknown. Here we reported that upregulated expression ventricular tissues and endothelial overexpression transgenic mice (Tg) limited infarct size, attenuated cardiac dysfunction improved cardiomyocyte survival compared with their wild type littermates. These improvements were...
Sepsis induced endothelial cell dysfunction has been demonstrated to initiate immune responses and promote the infiltration of cells into organs, resulting in organ injury. Heat shock protein A12B (HSPA12B) is predominantly expressed cells. The present study investigated role HSPA12B regulation macrophage pro-inflammatory during sepsis. Wild type (WT) HSPA12B-/- mice were subjected CLP Worsened cardiac increased mortality observed septic mice, when compared with WT mice. showed spleen,...
Traumatic brain injury (TBI) is a significant worldwide public health concern that necessitates attention. Apoptosis signal-regulating kinase 1 (ASK1), key player in various central nervous system (CNS) diseases, has garnered interest for its potential neuroprotective effects against ischemic stroke and epilepsy when deleted. Nonetheless, the specific impact of ASK1 on TBI underlying mechanisms remain elusive. Notably, mutation ATP-binding sites, such as lysine residues, can lead to...
Abstract Homeostatic chemokines such as CCL19, CCL21, and CXCL13 are known to elicit chemotaxis from naive T B cells play a critical role in lymphocyte homing appropriate zones within secondary lymphoid organs (SLO). Here we tested whether CCL21 modulate murine motility the absence of concentration gradients, using videomicroscopy directly observe migration single cells. treatment induced rapid polarization sustained random with average speeds 5.16 ± 2.08 μm/min; cell (average velocity 4.10...
Aging-induced cardiac dysfunction is a prominent feature of aging. Heat shock protein 27 (HSP27) protects function against ischemia or chemical challenge. We hypothesized that HSP27 attenuates Transgenic (Tg) mice with cardiac-specific expression the gene and wild-type (WT) littermates were employed in experiments. Echocardiography revealed significant decline old WT compared young mice. In striking contrast, aging-induced impairment was attenuated Tg Levels aging markers lower mouse hearts...
This paper uses a multi-period PSM-DID model to explore the impact of land transfers on food production from spatial perspective and analyses income effects, scale structural effects such transfers. The empirical results are as follows. (1) Land have reduced proportion crops planted by farmers, planting structure has shifted towards cash crops, which obvious effects. (2) is spatially heterogeneous. more common in south than north. wheat north, while rice been south. (3) increased operating...
Angiogenesis is essential for cardiac functional recovery after myocardial infarction (MI). HSPA12B predominately expressed in endothelial cells and required angiogenesis. Yes-associated protein (YAP) plays an important role tumor This study investigated the cooperative of YAP angiogenesis MI. Silencing either or impaired hypoxia-promoted cell proliferation Deficiency suppressed expression nuclear translocation hypoxia. Knockdown attenuated hypoxia-stimulated abrogated HSPA12B-promoted...
To address the issue of single-crop adaptability current head-forming leafy vegetable harvesters in China—which limits their ability to harvest multiple varieties—a universal cabbage–Chinese cabbage harvesting platform was designed. This design based on statistical analysis physical and planting parameters major Chinese varieties Jiangsu Zhejiang provinces. The adopts a modular design, enabling both by replacing specific components adjusting relevant parameters. Through theoretical key...
Introduction Eg.P29 is a specific protein of E.granulosus metacestod, and has been able to induce high levels protection in mice sheep against challenge with protoscolex . Therefore, plays crucial role the growth development E. granulosus metacestode. However, function remains unknown. During process life, commonly other proteins form complex network interactions play function. In this study, we identified interacting molecules for foundation exploring Methods Some basic information about...
Natural protein-based biomaterials with complex hierarchical structures often have incredible and even counterintuitive mechanical properties. Understanding utilizing the conformational transition mechanisms of natural proteins will further guide design natural-inspired biomaterials. In this study, a small static-force-induced spatiotemporal "freezing" phenomenon silk fibroins confined in porous carbon nanotube sponges has been investigated. The not only bring shape memory effect to elastic...