A5021345013- Air Quality and Health Impacts
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Glioma Diagnosis and Treatment
- Asthma and respiratory diseases
- Carcinogens and Genotoxicity Assessment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Brain Metastases and Treatment
- Occupational exposure and asthma
- Toxic Organic Pollutants Impact
- Analytical Chemistry and Chromatography
- Plant biochemistry and biosynthesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- RNA Interference and Gene Delivery
- Climate Change and Health Impacts
- Mass Spectrometry Techniques and Applications
- Effects and risks of endocrine disrupting chemicals
- Energy and Environment Impacts
- Indoor Air Quality and Microbial Exposure
- Plant Physiology and Cultivation Studies
- Birth, Development, and Health
- Heavy Metal Exposure and Toxicity
- Pharmacological Effects of Natural Compounds
Oita University of Nursing and Health Sciences
2013-2023
Niigata University
1993-2015
Oita University
2013
Tsubame Rosai Hospital
2011
Shiseido Group (Japan)
1992-2009
Niigata Cancer Center Hospital
1998-2009
Weatherford College
2009
Japan Science and Technology Agency
2002-2008
Tokyo University of Science
1958-2007
The University of Tokyo
1957-2002
Particulate matter 2.5 (<PM2.5 μm) leads to chronic obstructive pulmonary disease. In this study, biomarkers related inflammation and oxidative stress in vitro vivo experiments were investigated clarify the PM2.5-induced lung mechanisms. an study using RAW264.7 cells, PM2.5 caused phosphorylation of nuclear factor-κB, p38 mitogen-activated protein kinase extracellular response kinases, increase proinflammatory gene expressions (e.g. monocyte chemotactic protein-1, tumor necrosis factor-α)....
Abstract Purpose: To investigate the safety and immunologic clinical responses of dendritic cell therapy for patients with recurrent malignant glioma. Experimental Design: Twenty-four glioma (6 grade 3 18 4 patients) were evaluated in a phase I/II study therapy. All resistant to standard maximum The patient's peripheral blood cells generated granulocyte macrophage colony-stimulating factor, plus interleukin or without OK-432, pulsed an autologous tumor lysate. Dendritic injected...
Summary The effects of nanoparticles toward on the male reproductive system mice were investigated. Three sizes (14, 56 and 95 nm) carbon black intratracheally administered (0.1 mg/mouse for 10 times every week) to ICR investigate their adverse function. serum testosterone levels elevated significantly in 14‐ 56‐nm nanoparticles‐exposed groups. Histological examination showed partial vacuolation seminiferous tubules. In addition, particle number towards controlled 14‐nm group (14 N group,...
Nevertheless its mechanism has not been well explained yet, PM2.5 is recognized to exacerbate asthma. In the present study, roles of toll-like receptor (TLR) 2, TLR4 and MyD88, in exacerbation allergen-induced lung eosinophilia caused by urban was investigated. TLR2-, TLR4-, MyD88-deficient WT BALB/c mice were intratracheally challenged with +/- ovalbumin (OVA) four times at 2-week intervals. increased neutrophil numbers KC bronchoalveolar lavage fluid slight peribronchiolar inflammation...
Several recent reports have suggested that sperm count and quality in normal men are declining. Various environmental chemical compounds may affect the male reproductive system. We propose here diesel exhaust is an pollutant with potential to influence function. Ultrastructural changes were observed Leydig cells of mice exposed (0.3 mg particles (DEP)/m3 through airway, 12 h daily, up 6 months) reduction LH receptor mRNA expression was at a concentration 1 DEP/m3. Daily production per gram...
The aggravating effects of Asian sand dust (SD) and related minerals on the allergic inflammation were examined in murine lungs. toxic materials adsorbed onto SD, Arizona SD inactivated by heat-treatment. ICR mice administered mineral samples (0.1 mg/mouse) and/or ovalbumin (OVA) (1 microg/mouse) - normal saline (control), SiO2, Al2O3, OVA, OVA + Al2O3 intratracheally four times at two-week intervals. All tested enhanced eosinophil recruitment induced submucosa airway, which has a goblet...
Genetic and epigenetic status, including mutations of isocitrate dehydrogenase ( IDH ) TP 53 methylation O 6 ‐methylguanine‐DNA methyltransferase MGMT ), are associated with the development various types glioma useful for prognostication. Here, using routinely available histology sections from 312 patients diffuse gliomas, we performed immunohistochemistry antibodies specific I DH 1 mutation, aberrant p53 expression to evaluate possible prognostic significance these features. With regard...
The effect of prenatal exposure to diesel exhaust (DE) was investigated. Twenty pregnant ICR mice were exposed DE at the particle concentration 1.0 mg/m3, from d 2 until 16 postcoitum. Male offspring kept alive 12 wk age, and then male reproductive organ weight, daily sperm production (DSP), serum testosterone level, mRNA expression sex steroid hormone synthesis process-related factors measured. Serum levels group reduced significantly 3 wk, whereas they elevated wk. DSP also markedly 5...
ABSTRACT Epidemiologic studies have reported that Asian sand dust (ASD) particles can affect respiratory health; however, the mechanisms remain unclear. We investigated effects of ASD on airway epithelial cells and immune cells, their contributing factors to effects. Human were exposed collected 1–3 May (ASD1) 12–14 (ASD2) 2011 in Japan heat‐treated ASD1 for excluding heat‐sensitive substances (H‐ASD) at a concentration 0, 3, 30 or 90 µg ml –1 4 24 h. Furthermore, bone marrow‐derived...
Bjerkandera adusta (B. adusta) is one of the most important etiological fungi associated with chronic cough. However, precise details inflammatory response to exposure are not well understood yet. B. was recently identified in Asian sand dust (ASD) aerosol. Therefore, present study exacerbating effects ASD on adusta-induced lung inflammation and + ovalbumin (OVA)-induced murine eosinophilia were investigated using experimental mice. In order prepare testing samples, obtained from aerosol...
Distant metastasis is one of the crucial parameters determining type treatment and prognosis patients. Previous studies discovered important factors involved in multiple steps metastasis, precise mechanisms still remain to be clarified. To identify genes associated with this complicated biological feature cancer, we analyzed expression profiles 16 metastatic brain tumors derived from primary lung adenocarcinoma (ADC) using cDNA microarray representing 23,040 genes. We applied bioinformatic...
There is no experimental study demonstrating the effects of airborne Asian sand dust (AASD) on allergic lung eosinophilia. The organic substances adsorbed onto AASD collected from atmosphere Iki-island in Japan were excluded by heat treatment at 360°C for 30 min. or heated-AASD (H-AASD) towards inflammation compared murine lungs to investigate role substances. ICR mice administrated with two kinds and/or ovalbumin (OVA) intratracheally four times 2-week intervals. and H-AASD enhanced...
PM2.5 can exacerbate asthma. Organic substances adsorbed on PM2.5-rich dust (PM2.5rd) were inactivated by heating at 360 °C. To characterize the role of organic substances, effects PM2.5rd and heated (H-PM2.5 rd) allergic lung inflammation investigated. BALB/c mice intratracheally administered or H-PM2.5rd with without ovalbumin (OVA) four times 2-week intervals. PM2.5rd, but not H-PM2.5rd, caused neutrophilic alveolitis bronchitis. In presence OVA, severe eosinophil infiltration goblet...