A5068125428- Estrogen and related hormone effects
- Retinoids in leukemia and cellular processes
- Effects and risks of endocrine disrupting chemicals
- Sphingolipid Metabolism and Signaling
- Phytoestrogen effects and research
- Antioxidant Activity and Oxidative Stress
- bioluminescence and chemiluminescence research
- Biomedical Research and Pathophysiology
- Nuclear Receptors and Signaling
- Cholesterol and Lipid Metabolism
- Viral Infectious Diseases and Gene Expression in Insects
- Birth, Development, and Health
- Cardiac and Coronary Surgery Techniques
- Protein Degradation and Inhibitors
- Stress Responses and Cortisol
- Lipid Membrane Structure and Behavior
- Computational Drug Discovery Methods
- Neuroinflammation and Neurodegeneration Mechanisms
- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Atherosclerosis and Cardiovascular Diseases
- Chromatography in Natural Products
- Porphyrin and Phthalocyanine Chemistry
- Olfactory and Sensory Function Studies
- Redox biology and oxidative stress
Research Foundation ITSUU Laboratory
2009-2025
Food and Drug Safety Center
1997-2017
The University of Tokyo
2002-2013
Kindai University
2003-2004
Alzheimer's disease (AD) is a neurodegenerative process involving amyloid-β (Aβ) peptide deposition, neuroinflammation, and progressive memory loss. Here, we evaluated whether oral administration of retinoic acid receptor (RAR)α,β agonist Am80 (tamibarotene) or specific retinoid X (RXR) pan HX630 their combination could improve deficits in an AD model, 8.5-month-old protein precursor 23 (AβPP23) mice. Co-administration (0.5 mg/kg) (5 for 17 days significantly improved (Morris water maze)...
The purpose of this study is to investigate whether a synthetic retinoid Am80 (tamibarotene) exhibits any improving effects on amyloid precursor protein (APP)23 mice, model Alzheimer's disease. was orally administered in feed 20-week (5-month)-old APP23 mice at dose 0 (control) or 0.5 mg/kg/d for 14 weeks. treatment reduced significantly the insoluble Abeta levels brain, particular Abeta(42), while it gave no apparent soluble levels. results suggest that oral administration may have potency...
A number of alkylphenolic compounds are used in a variety commercial products and have been shown vitro studies to be weakly estrogenic, but few vivo data available addressing this issue mammals. Human ex-posure alkylphenols may occur not only from these environmental contaminants also through contact with manufactured metabolic breakdown products. The reproductive function rats treated subcutaneously nonylphenol (NP, 500 mg/kg/day) or 17Q3-estradiol (E 2 , as positive control, postnatal...
Abstract The effects of ten endocrine disrupting chemicals, i.e., bisphenol A (BPA), p ‐nonylphenol (NP), ‐octylphenol (OP), ‐pentylphenol (PP), butyl benzyl phthalate (BBP), dicyclohexyl (DCHP), di‐ n ‐butyl (DBP), tetrabutyltin (TBT), tri‐ ‐butyltin chloride (TBC), and dichloride (DBD), as well 17β‐estradiol (E 2 ) a positive control on the microtubule network in Chinese hamster V79 cells culture were examined by indirect immunofluorescence method using anti‐β‐tubulin antibody. In...
We developed a bio-artificial liver (BAL) using radial-flow bioreactor and rescued mini-pig models with lethal acute failure (ALF). The point of the rescue is recovery from hepatic encephalopathy (HE). HE on ALF has sometimes resulted in brain death following edema astrocyte swelling. Several factors, including ammonia glutamine, have been reported to induce swelling injury. However, many clinicians believe that there are any other factors involved development HE. Therefore, aim this study...
Abstract Bisphenol A (BPA), 4‐nonylphenol (NP) and butyl benzyl phthalate (BBP), termed endocrine‐disrupting chemicals, are known to mimic estrogen activity. The effects of these chemicals on 17β‐estradiol (E 2 ) metabolism in vivo rats were examined. Male female given NP (250 mg kg –1 day ), BPA μg or BBP (500 by gavage for 14 days, followed a single intraperitoneal injection E (5 the final day. urinary excretion over 72 hours 2‐hydroxyestrone 1‐ N ‐acetylcysteine thioether, 4‐...
Estrogen receptor (ER) is a hormone‐inducible transcription factor as member of the nuclear gene superfamily. Unliganded ER transcriptionally silent and capable DNA binding; however, it unable to suppress basal activity target promoters, unlike non‐steroid hormone receptors that associate with corepressors in absence their cognate ligands. To study molecular basis how unliganded human ERα maintained regulation upon we biochemically searched interactants for hERα, identified heat shock...
A method for the analysis of N-acetylcysteine conjugates catechol estrogens [catechol estrogen mercapturates (CE SRs)], which are likely to be urinary markers estrogen-induced tumors, was established in this study. The characteristics that were (1) cleanup urine using immunoaffinity column CE SRs, (2) detection (CEs) and SRs by electrochemical detection, provided high specificity, (3) stability through cleanup. Using method, simultaneous quantitation 2-hydroxy-17β-estradiol (2-OHE2),...
Firefly luciferase (Luc) is widely used as a reporter enzyme in cell-based assays for gene expression. A novel aromatic carboxylic acid, F-53, reported here the first time, substantially inhibited enzymatic activity of Luc screening. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) and tandem (MS/MS) analyses showed that F-53 modifies at lysine-529 via amidation carboxyl group. The residue Luc, which plays regulatory catalytic role, can be...
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