A5000147737- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Coordination Chemistry and Organometallics
- Asymmetric Synthesis and Catalysis
- Metabolomics and Mass Spectrometry Studies
- Organometallic Complex Synthesis and Catalysis
- Dialysis and Renal Disease Management
- Immune Response and Inflammation
- Diet and metabolism studies
- Estrogen and related hormone effects
- Hemoglobin structure and function
- Cancer, Hypoxia, and Metabolism
- Neurological and metabolic disorders
- Catalytic Cross-Coupling Reactions
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Porphyrin and Phthalocyanine Chemistry
- Photosynthetic Processes and Mechanisms
- Nutrition and Health in Aging
- Chronic Kidney Disease and Diabetes
- Erythropoietin and Anemia Treatment
- Analytical Chemistry and Chromatography
- Lysosomal Storage Disorders Research
- Biotin and Related Studies
- Metabolism and Genetic Disorders
Tohoku University
2013-2025
Koga Hospital
2025
Sendai University
2019-2020
Tohoku University Hospital
2011-2019
RELX Group (United States)
2017
Teikyo University
2014-2016
The University of Tokyo
2004-2014
RIKEN Advanced Science Institute
2012
RIKEN
2006-2009
Hokuriku University
2008
Diabetic kidney disease is a major cause of renal failure that urgently necessitates breakthrough in management. Here we show using untargeted metabolomics levels phenyl sulfate, gut microbiota-derived metabolite, increase with the progression diabetes rats overexpressing human uremic toxin transporter SLCO4C1 kidney, and are decreased limited proteinuria. In experimental models diabetes, sulfate administration induces albuminuria podocyte damage. diabetic patient cohort, significantly...
Gut microbiota is involved in the metabolism of uremic solutes. However, precise influence to retention solutes CKD obscure. To clarify this, we compared adenine-induced renal failure and control mice under germ-free or specific pathogen-free (SPF) conditions, examining metabolite profiles plasma, feces, urine using a capillary electrophoresis time-of-flight mass spectrometry-based approach. Mice with conditions demonstrated significant changes plasma metabolites. Among 183 detected solutes,...
An aluminum ate base, i-Bu(3)Al(TMP)Li, has been designed and developed for regio- chemoselective direct generation of functionalized aromatic compounds. Direct alumination followed by electrophilic trapping with I(2), Cu/Pd-catalyzed C-C bond formation, or oxidation molecular O(2) proved to be a powerful tool the preparation 1,2- 1,2,3-multisubstituted This deprotonative using i-Bu3Al(TMP)Li was found effective in aliphatic chemistry as well, enabling addition allylic ethers carbamates...
Toll-like receptor 4 (TLR4) is an indispensable immune for lipopolysaccharide (LPS), a major component of the Gram-negative bacterial cell wall. Following LPS stimulation, TLR4 transmits signal from surface and becomes internalized in endosome. However, spatial regulation signaling not fully understood. Here, we investigated mechanisms LPS-induced internalization clarified roles extracellular LPS-binding molecules, protein (LBP), glycerophosphatidylinositol-anchored (CD14). stimulation...
Accumulation of uremic toxins, which exert deleterious effects in chronic kidney disease, is influenced by the intestinal environment; microbiota contributes to production representative including p-cresyl sulfate and indoxyl sulfate. Canagliflozin a sodium-glucose cotransporter (SGLT) 2 inhibitor, it also exerts modest inhibitory effect on SGLT1. The inhibition SGLT1 can influence gastrointestinal environment. We examined canagliflozin accumulation toxins disease using adenine-induced renal...
We systematically investigated, for the first time, relationship between regioselectivity and acid/base effects in cyclization reactions carboxylic acids carbon-carbon triple bonds. found novel acid- base-promoted cyclizations to selectively give isocoumarin or pyran-2(2H)-one phthalide furan-2(5H)-one skeletons, respectively, established a catalytic version of regioselective heterocyclic ring synthesis. Density functional theory calculations application short route thunberginol A were also...
The novel directed ortho metalation (DoM) reagents for functionalized aromatic rings, TMP-Zn-ates (R2Zn(TMP)Li (R = Me, 1; tBu, 2)), have been reported to be synthetically useful the chemo- and regioselective construction of multi-functionalized compounds. Here, we present first comprehensive structural mechanistic investigation by means X-ray, NMR, DFT studies on DoM reaction employing our original TMP-Zn-ate base. structures in solution solid state were determined. study strongly suggested...
A versatile preparation method for aromatic zincate compounds through a halogen−zinc exchange reaction using dilithium tetra-tert-butylzincate (tBu4ZnLi2) has been developed. This reagent permits efficient of highly functionalized zincates, particularly, those with electrophilic functional groups, such as ester, amide, alcohol, and phenol. Halogen−zinc reactions followed by trapping (with allyl bromide or benzaldehyde) proved to be powerful tool C−C bond formation on rings. The intermediate...
Elevated circulating uremic toxins are associated with a variety of symptoms and organ dysfunction observed in patients chronic kidney disease (CKD). Indoxyl sulfate (IS) p-cresyl (PCS) representative that exert various harmful effects. We recently showed IS induces metabolic alteration skeletal muscle causes sarcopenia mice. However, whether organ-specific accumulation PCS is tissue still unclear. investigated the using liquid chromatography/tandem mass spectrometry tissues from mice...
Abstract For see ChemInform in Full Text.
We present full details of the unique reactivities newly developed dianion-type bulky zincate, dilithium tetra-tert-butylzincate (tBu(4)ZnLi(2)). With this reagent, halogen-zinc exchange reaction variously functionalized haloaromatics and anionic polymerization N-isopropylacrylamide (NIPAm)/styrene with excellent chemoselectivity were realized. Halogen-zinc followed by electrophilic trapping propargyl bromide provided a convenient route to phenylallenes, particularly those functional groups...
Rationale: Pulmonary arterial hypertension (PAH) is characterized by enhanced proliferation of pulmonary artery smooth muscle cells (PASMCs) accompanying increased production inflammatory factors and adaptation the mitochondrial metabolism to a hyperproliferative state. However, all drugs in clinical use target vascular dilatation, which may not be effective for patients with advanced PAH. Objective: We aimed discover novel drug PAH that inhibits PASMC proliferation. Methods Results:...
Patients with end-stage renal disease have lower fasting plasma glucose and HbA1c levels, significantly higher insulin levels. For a long time, it has been believed that this level in failure is due to decreased clearance caused by reduced function. However, here we reported accumulation of the gut microbiota-derived uremic toxin, phenyl sulfate (PS) failure, increased secretion from pancreas enhanced glucose-stimulated secretion. Other endogenous sulfides compounds which accumulated as also...
We have developed a catalytic electron transfer (ET) system composed of transition metal ate complex (Me3M(II)Li; M = Co(II), Mn(II), Fe(II)) and magnesium. This (catalytic Me3M(II)Li/Mg) turned out to be effective for various ET reactions, such as the desulfonylation N-phenylsulfonyl amides, others (the chemoselective cleavage O-allyl groups, reduction nitro partial diketones, reductive coupling diphenyliodonium salt). The ability this can tuned by changing ligands complexes. tunability was...
Niemann-Pick disease type C (NPC) is an autosomal recessive disorder caused by the mutation of cholesterol-transporting proteins. In addition, early treatment important for good prognosis this because progressive neurodegeneration. However, diagnosis difficult due to a variety clinical spectrum. Lysosphingomyelin-509, which one most useful biomarkers NPC, was applied rapid and easy detection NPC. The fact that its chemical structure unknown until recently implicates unrevealed...
The erythroid growth factor erythropoietin (EPO) is mainly produced by the kidneys in adult mammals and induces expansion of cells iron use for hemoglobin synthesis. liver also produces EPO at a lower level than kidneys. Renal hepatic production fundamentally regulated hypoxia-inducible transcription factors (HIFs) hypoxia/anemia-inducible manner. Recently, small compounds that activate HIFs inhibiting HIF-prolyl hydroxylases (HIF-PHIs) have been launched to treat EPO-deficiency anemia...
Transition-state structures of the type illustrated were found to be crucial in determining whether directed ortho-metalation (DoM) or 1,2-addition occurs reaction benzonitrile methyl benzoate with Me2Zn(TMP)Li (MeLi)2. The origin high chemoselectivity was investigated. TMP=2,2,6,6-tetramethylpiperidide. Supporting information for this article is available on WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z602664_s.pdf from author. Please note: publisher not responsible content...
The electronic structures of a homologous series indole and benzofuran derivatives, in which the nitrogen or oxygen atom is replaced by group 15 16 heavier heteroatoms, have been investigated means various spectroscopic techniques coupled with density functional calculations. It was found that excitation energies benzoheteroles systematically shift to red order (6), benzothiophene (7), benzoselenophene (8), benzotellurophene (9). In contrast, absorption spectra benzoheteroles, 1-phenyl...
Abstract Carboxyl-containing metabolites, such as bile acids and fatty acids, have many important functions microbiota is involved in the production of them. In previous study, we found that chronic kidney disease (CKD) model mice raised under germ-free conditions provided more severe renal damage than with commensal microbiota. However, precise influence by microbiome carboxyl-containing metabolites to unknown. this aimed develop a novel chemical isotope labeling-LC-MS/MS method using...
Abstract Sensitive biomarkers can enhance the diagnosis, prognosis, and surveillance of chronic kidney disease (CKD), such as diabetic (DKD). Plasma growth differentiation factor 15 (GDF15) levels are a novel biomarker for mitochondria-associated diseases; however, it may not be useful indicator CKD its increase with declining renal function. This study explores urinary GDF15’s potential marker CKD. The plasma GDF15 well uremic toxins were measured in 103 patients relationship between...