A5019097189- Forensic Anthropology and Bioarchaeology Studies
- Paleopathology and ancient diseases
- Philosophical and Theoretical Analysis
- dental development and anomalies
- Psychoanalysis and Psychopathology Research
- Neurology and Historical Studies
- Forensic and Genetic Research
- Crystallization and Solubility Studies
- Oral and Maxillofacial Pathology
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- X-ray Diffraction in Crystallography
- Archaeology and ancient environmental studies
- Cleft Lip and Palate Research
- Hormonal and reproductive studies
- Crystallography and molecular interactions
- Regulation of Appetite and Obesity
- Academic and Historical Perspectives in Psychology
- Dental Health and Care Utilization
- Historical and Literary Studies
- Bone health and treatments
- Forensic Entomology and Diptera Studies
- Pharmacological Effects and Toxicity Studies
- Material Properties and Processing
- Historical and Scientific Studies
Takeda (Japan)
2007-2025
Kanazawa University
2023-2025
Doshisha University
2021
Niigata College of Nursing
2008-2020
Toyama Prefectural University
2013-2017
National Institute of Health Sciences
2017
Kyushu Sangyo University
2012
Japan Society for the Promotion of Science
2009
Gifu University
2007
Savoirs, Textes, Langage
2006
Many diseases, especially cancers, result from aberrant or overexpression of pathogenic proteins. Specific inhibitors against these proteins have shown remarkable therapeutic effects, but are limited mainly to enzymes. An alternative approach that may utility in drug development relies on selective degradation via small chimeric molecules linking an E3 ubiquitin ligase the targeted protein for proteasomal degradation. To this end, we recently developed a knockdown system based hybrid...
Alzheimer's disease (AD) is a neurodegenerative disorder leading to progressive loss of cognitive function and pathologically characterized by senile plaques neurofibrillary tangles. Glycogen synthase kinase-3 (GSK-3) involved in AD pathogenesis. GSK-3 reported not only phosphorylate tau, major component tangles, but also regulate the production amyloid β, which deposited plaques. Therefore, pharmacological inhibition considered an attractive therapeutic approach. In this study, we report...
This study aims to estimate the average life expectancy (LE) of Tokugawa Shogun family by analyzing historical documents. The data is also compared modern Japanese figures. lifespan members estimated based on from Edo-period We assess survival rates age, sex, and other factors. Lunar calendar dates are converted into solar dates, birth years counted as age 0 ensure that LE comparable estimates, free bias. mean at (LEB) for males in 20.93 ± 25.03 years, females, it 20.53 25.16 years. pooled...
Heteroduplex oligonucleotide (HDO) is a novel therapeutic consisting of an antisense (ASO) and its complementary RNA. A recent report showed that cholesterol-conjugated HDO (Chol-HDO) exhibited activity in various tissues, including the brain; however, little information available on pharmacokinetic plasma protein-binding properties Chol-HDO. In present study, we investigated tissue distributions ASO, HDO, Chol-HDO mice rats after intravenous injection. Tissue distribution was evaluated by...
Oral bioavailability of some drugs is substantially lower in cynomolgus monkeys than various other species, including humans. In the present study, midazolam was used as a model drug to investigate reason for these monkeys. The after oral administration minimal and rats, being only 2.1 1.1%, respectively. monkeys, this low could not be explained simply terms hepatic first-pass effect. To examine roles intestinal metabolism transport, we evaluated apical-to-basal basal-to-apical transport...
Abstract Tuberculosis has been recognized in Japan and Korea for more than 500 years historical medical documents. However, the origin early existence of tuberculosis is poorly understood these regions. Very recently, skeletal evidence from Bronze Age (or Aneolithic) period was reported Korea. This article describes a possible case spinal an archeological site Korea, which dated to first century BC. date corresponds Aneolithic (Yayoi) Japan. Skeletal during found both are, therefore,...
Background and Purpose Neuromedin U (NmU) may be a novel target for obesity treatment owing to its anorectic energy expenditure enhancing effects. Although two receptors, NMU1 NMU2, are both responsible the NmU‐mediated anti‐obesity effects, receptor agonist with most appropriate profiles treating diabetes in terms of efficacy safety is as yet unknown. Thus, we developed evaluated NMU1/2 receptor‐selective agonists. Experimental Approach Efficacy were assessed mice diet‐induced (DIO) those...
Dental caries of Japanese Neolithic Jomon skeletons derived from the thirteen sites was investigated. Results indicated that (1) is infrequent in teeth early stage, (2) affected by increased and after middle stages, (3) shell middens facing open sea possibly has high degree rate rather than those inland sea, (4) late final regardless locations, had a certain measure caries. From these results one may say incidences dental differ according to geographical and/or chronological circumstances....
Sarcopenia and cachexia present characteristic features of a decrease in skeletal muscle mass strength, anorexia, lack motivation. Treatments for these diseases have not yet been established, although selective androgen receptor modulators (SARMs) are considered as therapeutic targets. We previously reported that novel SARM compound, SARM-2f, exhibits anabolic effect on muscles, with less stimulatory prostate weight compared testosterone, rat Hershberger assays cancer models. In this study,...
General hyperostotic diathesis diagnosed as diffuse idiopathic skeletal hyperostosis (DISH) was found in an almost complete skeleton from the Edo period (1603-1867 A.D.) and is described here a paleopathological view point. A remarkable ossification thoracolumbar spines, partly forming ankylosis between Th-12 L-1 by exuberant osteophytes with "dripping wax" and/or "candle flame" appearance. In extraspinal skeleton, abnormal hyperostoses were at muscle ligament attachments both axial...
Bergson's Hand: Toward a History of (Non)-Organic Vitalism Hisashi Fujita Japan Society for the Promotion Science translated by Roxanne Lapidus "Today vitalism is sterile, but it will not always be so." —Henri Bergson Introduction Let me say at outset that my question whether or was vitalist. If defined as theory proposes "vital force" underlying phenomena which transforms matter into living, organized while stressing its irreducibility to physico-chemical phenomena, and if one takes account...
Neuromedin U (NMU) is a neuropeptide that mediates variety of physiological functions via its receptors, NMUR1 and NMUR2. Recently, there has been an increased focus on NMU as promising treatment option for diabetes obesity. A short form (NMU-8) potent agonist activity both receptors but metabolically unstable. Therefore, we designed synthesized NMU-8 analogues modified by polyethylene glycol (PEG; molecular weight, 20 kDa; PEG20k) linker. 3-(2-Naphthyl)alanine substitution at position 19...
The purpose of our study is to develop an algorithm that would enable the automated detection lacunar infarct on T1-and T2-weighted magnetic resonance (MR) images. Automated identification regions not only useful in assisting radiologists detect infarcts as a computer-aided (CAD) system but also beneficial preventing occurrence cerebral apoplexy high-risk patients. are classified into following two types for detection: “isolated regions” and “lacunar adjacent hyperintensive structures.”...
As part of our research for novel calcium-sensing receptor (CaSR) antagonists that can function as oral bone anabolic agents, we recently reported the discovery a tetrahydropyrazolopyrimidine derivative featuring adamantyl group 1b with potent CaSR antagonistic activity. To explore potential this calcilytic congener, introduced gem-dialkyl benzyl at 3-position ring, forming bioisostere by mimicking group's lipophilicity and bulkiness. Optimization directed toward improvement solubility...