Purpose.: To assess the relationship between visual function and macular ganglion cell complex (GCC) thickness measured by Fourier-domain optical coherence tomography (OCT) to evaluate diagnostic value of GCC for detecting early, moderate, severe glaucoma. Methods.: Participants underwent reliable standard automated perimetry testing OCT imaging with optic nerve head (ONH) mode within a single day. The structure was evaluated comparing mean deviation (MD) field index (VFI), regression...

To compare the effectiveness, safety, and stability of laser epithelial keratomileusis (LASEK), a modified photorefractive keratectomy (PRK) technique, with those conventional PRK for low to moderate myopia.Department Ophthalmology, Yonsei University School Medicine, Seoul, Korea.In this prospective study, 27 patients manifest refraction -3.00 -6.50 diopters were treated followed 3 months. In each case, was performed in 1 eye LASEK other eye. The first surgical method used randomized....

<h3>Aim</h3> To compare the diagnostic ability to detect glaucomatous changes between peripapillary retinal nerve fibre layer (RNFL) thickness and macular ganglion cell complex (GCC) in highly myopic patients using Fourier domain optical coherence tomography. <h3>Methods</h3> Participants, consecutively enrolled from January 2009 June 2009, were imaged with RTVue-100 (NHM4 MM7 scan). The sensitivity specificity of a colour code less than 5% (red or yellow) for glaucoma diagnosis calculated....

To determine the effects of age, sex, spherical equivalent, axial length, anterior chamber depth, optic disc area, and central corneal thickness on perimacular inner retinal layer in normal human eye as measured by Fourier-domain optical coherence tomography (FD-OCT).In this cross-sectional observational study, 182 Korean healthy subjects aged from 22 to 84 years were included. obtain thickness, ganglion cell complex which extends internal limiting membrane nuclear layer, was FD-OCT one...

Purpose: Based on the vascular theory of glaucoma pathogenesis, we wanted to evaluate effect Ginkgo biloba extract (GBE) peripapillary blood flow in patients with normal tension (NTG).Methods: Thirty NTG were randomly placed GBE-treated or control groups.The group received 80 mg GBE orally, twice a day for four weeks, and placebo weeks.Complete ocular examinations including visual field, Heidelberg retina flowmeter, systemic performed first study treatment was completed.Results: After...

To compare perimacular ganglion cell complex (GCC) parameters between patients with normal tension glaucoma (NTG) and primary open-angle (POAG).Participants, consecutively enrolled from January 2009 to June 2009, underwent optical coherence tomographic imaging RTVue-100 (Optovue Inc, Fremont, CA). Optic nerve head (ONH) parameters, retinal fiber layer (RNFL) GCC were acquired. Mean measurements of ONH, RNFL, among the normal, NTG, POAG groups compared using analysis variance. Area under...

Abstract Purpose To assess the associations between vascular and metabolic comorbidities prevalence of open‐angle glaucoma ( OAG ) with low‐teen high‐teen intraocular pressure IOP in Korea. Methods Cross‐sectional data from Korean National Health Nutrition Examination Survey 2008 to 2012 were analysed. Participants diagnosed normal further classified into ≤ 15 mmHg) (15 mmHg &lt; 21 groups. Using multiple logistic regression analyses, investigated for low‐ Results The prevalences...

Purpose: To determine risk factors associated with structural progression in medically treated normal-tension glaucoma (NTG). Methods: This retrospective cohort study included 166 NTG patients (average age, 56.5 years; average mean deviation, −4.2 dB). The endpoint was determined by optical coherence tomography; significant thickness differences the peripapillary retinal nerve fiber layer (RNFL) or macular ganglion cell inner plexiform (GCIPL) that exceeded baseline test-retest variability...

The aim of the present study was to determine effect purified high-dose anthocyanoside oligomer administration on nocturnal visual function and clinical symptoms in low-to-moderate myopia subjects. a randomized, double-blind, placebo-controlled trial involved sixty subjects with asthenopia refractive errors between −1·00 −8·00 diopters both eyes. Thirty were administered (100 mg tablet comprising 85 % oligomer), thirty given placebo form twice daily for 4 weeks. Prior treatment, groups...

Agmatine is an endogenous polyamine formed by the decarboxylation of L-arginine. We investigated protective effects agmatine against hypoxia-induced apoptosis immortalized rat retinal ganglion cells (RGC-5). RGC-5 were cultured in a closed hypoxic chamber (5% O2) with or without agmatine. Cell viability was determined lactate dehydrogenase (LDH) assay and examined annexin V caspase-3 assays. Expression phosphorylation mitogen-activated protein kinases (MAPKs; JNK, ERK p44/42, p38) nuclear...

Purpose:The purpose of this study was to investigate the prevalence and characteristics glaucoma in population rural Korean town, Sangju.Methods: Residents Sangju aged greater than 50 years old were included study.Participants completed an interview examining their medical ophthalmic history Information collected on participants' uncorrected best corrected vision scores, slit lamp examination results, angle width measurements using Van Herick technique, gonioscopy if less 1 / 4 angle,...

Abstract Although early glaucoma detection is important to prevent visual loss due disease progression, its clinical diagnosis in highly myopic eyes still difficult. Many studies using optical coherence tomography (OCT) angiography (OCTA) reported decreased vessel density (VD) glaucomatous compared normal eyes. We evaluated the diagnostic ability of peripapillary VD and macular measured by OCTA, comparing them with conventional valuables such as retinal nerve fibre layer (RNFL) thickness...

Intraocular pressure (IOP) fluctuations increase the risk of visual field progression primary open-angle glaucoma (POAG) in advanced stage even when IOP is maintained low on average.The purpose this study was to identify factors associated with defect patients POAG.A retrospective review medical records conducted who met Hodapp-Parrish-Anderson criteria for POAG. A total 122 eyes had undergone measurement Goldmann applanation tonometer, standard automated perimetry, Cirrus optical coherence...

PURPOSE. Although transforming growth factor-ßs (TGF-ßs) inhibit epithelial cell proliferation, these same substances stimulate proliferation of fibroblasts. In order to elucidate the mechanism stimulatory activity TGF-ß on fibroblast, present study was performed determine whether might be an indirect mitogen acting through induction endogenous factor(s) that then acts as direct in autocrine manner corneal stromal fibroblasts (CSFs). METHODS. Cell determined either by counting numbers or...

ABSTRACT PURPOSE: To compare the release of tear fluid transforming growth factor-?l (TGF-?l) 15 patients who underwent photorefractive keratectomy (PRK) in one eye and laser subepithelial keratomileusis (LASEK) other eye. METHODS: Tear samples were collected with scaled microcapUlary tubes preoperatively (day 0) on first, second, seventh postoperative days. We calculated TGF-β1 (tear flow-corrected concentrations TGF-β1) by multiplying concentration capillary flow also evaluated corneal...

Retinal pigment epithelium (RPE) cells of the proliferative vitreoretinopathy (PVR) membrane take on shape fibroblasts and participate in fibrosis, thus deviating from character epithelial cells. This study was undertaken to evaluate RPE cell transdifferentiation vitro. During culture porcine cells, primary 10th-passaged were investigated for growth response transforming factor (TGF) β&lt;sub&gt;2&lt;/sub&gt;, change phenotype amount collagen synthesis as well expression α-smooth-muscle...

To assess and compare the influence of cataract on measurements retinal nerve fiber layer (RNFL) thickness by time domain (TD) optical coherence tomography (OCT) spectral (SD) OCT.Patients who underwent uncomplicated surgery were consecutively enrolled in this study. The peripapillary RNFL was measured before 8 weeks after using TD-OCT SD-OCT during same visit. Changes measurement signal strength (SS) evaluated.A total 54 patients (54 eyes) included. After excluding 19 eyes owing to poor...