Interleukin 10 secreting genome-edited MSCs inhibited liver fibrosis and ameliorated abnormal function.

We aimed to compare the prognostic value of various predictors and complex scoring systems for prediction severe acute pancreatitis (SAP) according revised Atlanta classification.C-reactive protein (CRP) procalcitonin were obtained on admission, CRP level 24 hours after admission (CRP2) was measured. Various including Ranson, Acute Physiology Chronic Health Examination (APACHE II), Bedside Index Severity in Pancreatitis, Computed Tomography (CTSI) calculated.There 146 patients with (mean...

Although mesenchymal stem cells (MSCs) provide effective therapy for liver fibrosis, there are conflicting data regarding their marginal therapeutic effects. This study aimed to enhance the potential of hepatocyte regeneration in human adipose (ASCs) and investigate whether they have robust efficacy experimental fibrosis.ASCs were cultured with four cytokines (ASC-C), expression hepatogenic factors was detected by microarray, effects conditioned medium (CM) from ASC-C on activation hepatic...

Metabolic syndrome has clinical implications for chronic liver disease, but the relationship between hepatitis B and metabolic remains unclear. The aim of this study was to determine whether surface antigen (HBsAg) positivity is associated with syndrome.Data were obtained from Third Korean National Health Nutrition Examination Survey (KNHANES). Participant sera tested HBsAg. defined according modified Cholesterol Education Program Adult Treatment Panel III guidelines Koreans.Of 5108...

Abstract Background It is unclear whether obesity increases the incidence of acute pancreatitis (AP) in general population. Further, no study has prospectively examined associations risk AP by etiology with measured body mass index (BMI) values. Methods A total 512 928 Korean participants routine health examinations during 2002–2003 were followed up until 2013 via linkage to national hospital discharge records assess incidence. Multivariable‐adjusted hazard ratios calculated using BMI...

Abstract Background Cell therapy using hepatocytes derived from stem cells has been regarded as a promising alternate to liver transplantation. However, the heterogeneity of these makes them unsuitable for therapeutic use. To overcome this limitation, we generated homogenous hepatocyte like induced hepatocyte-like (iHep) cells. Methods iHep were pluripotent (iPSCs) integrated with albumin (ALB) reporter gene. The properties investigated after transplantation in fibrotic tissues mouse model....

False positives of fecal occult blood tests (FOBT) regarding colorectal cancer detection are common. The aim was to investigate the upper gastrointestinal (GI) condition confirmed by endoscopy in positive FOBT patients without advanced neoplasia, hemorrhoid, or colitis.The authors reviewed collective data 340 who underwent both esophagogastroduodenoscopy (EGD) and colonoscopy from January 2005 October 2011. Demographic data, effects medications, including antiplatelet agents, nonsteroidal...

Single nucleotide polymorphisms (SNPs) are associated with aspirin-induced peptic ulcers. However, SNPs of specific genes vary among races, and data regarding in the Korean population scarce. In this study, we aimed to investigate relationships between COX-1, IL-1β, IL-1RN, TNF ulcers, as pilot research a population.Patients who had been taking low-dose aspirin (100 mg) for at least 4 weeks were prospectively enrolled. DNA was extracted from whole blood, sequencing subsequently performed.A...

Several epidemiological studies have validated the association of interleukin gene polymorphisms with acute pancreatitis (AP) in different populations. However, there been few Asian ethnic groups. We aimed to investigate relationships between inflammatory cytokine and AP as pilot research a Korean group.Patients who had diagnosed were prospectively enrolled. DNA was extracted from whole blood, sequencing subsequently performed. Single-nucleotide (SNPs) 1β (IL1B), 1 receptor antagonist...

The magnetic capsule endoscope has been modified to be fixed inside the stomach and monitor gastric motility. This pilot trial was designed investigate feasibility of for monitoring swallowed by healthy volunteer maneuvered external magnet on his abdomen surface stomach. transmitted image peristalsis. simple suggested that real-time ambulatory motility should feasible using endoscope.

Conventional and herbal drugs are frequently used together to treat many disorders. Samryungbaekchul-san (SRS, a formula) otilonium bromide (OB, an antispasmodic agent) widely diarrhea-predominant irritable bowel syndrome (D-IBS) in Eastern Asian countries. However, there have been no studies on the co-administration of SRS OB. Therefore, we aimed preliminarily assess feasibility combined with OB for D-IBS treatment pilot double-blind, four-arm, parallel-group, randomized controlled trial...

Recently, three-dimensional (3D)-cultured adipose mesenchymal stem cells (ASCs) have provided an effective therapy for liver fibrosis. This study aimed to enhance the potential of human ASCs antifibrosis or hepatocyte regeneration using a 3D culture system and investigate their therapeutic mechanism in experimental ASC-3Dc were generated stimulated with four growth factors, namely epidermal factor, insulin-like factor (IGF)-1, fibroblast factor-2, vascular endothelial factor-A. The...

Cholangiocarcinoma (CCA), especially intrahepatic CCA, is known to share several risk factors with hepatocellular carcinoma (HCC) and liver cirrhosis has been proposed as a common pathogenic factor. We aimed identify the of CCA examine differences in between HCC. followed 510,217 Korean adults who underwent health checkups during 2002−2003 until 2013 via linkage national hospital discharge records. Hazard ratios (HRs) were calculated after adjustment for confounders. During mean follow-up...

Background: In Crohn’s disease (CD), intra-abdominal abscess (IA) and intestinal free-wall perforation (IP) have a common mechanism of transmural inflammation; however, their manifestation is different. Objective: This study aimed to investigate differences in the clinical features between IA IP Korean patients with disease. Design: A retrospective cohort study. Setting: Thirty university hospitals two local Korea. Patients: Patients who were diagnosed CD July 1982 December 2008 enrolled....

To investigate an association between fatty liver disease (FLD) and erosive oesophagitis.This was a cross-sectional study of subjects selected from examinees who underwent health check-up, including oesophagogastroduodenoscopy in one hospital 2004 2011. Erosive oesophagitis classified according to the Los Angeles classification FLD diagnosed with ultrasonography. The anthropometric laboratory data were analysed using χ2 test multivariate logistic regression. Additionally, we have our...

Background Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-lymphoma) is an extranodal that occurs at various sites in the body. There a limited understanding incidence and survival rates MALT-lymphoma. To investigate nation-wide MALT-lymphoma Korea during 1999-2017, data on were retrieved from Central Cancer Registry. Methods During time period 11,128 patients diagnosed with The age sex Surveillance, Epidemiology, End Results (SEER) summary stage tumor...

Protein S (PS), a vitamin K-dependent glycoprotein, performs an important role in the anticoagulation cascade as cofactor of protein C. Because presence pseudogene and two different forms PS plasma, deficiency (PSD) is one most difficult thrombophilias to study rare blood disorder associated with increased risk thrombosis. We describe unusual case previously healthy 37-year-old man diagnosed portal-splenic-mesenteric vein thrombosis secondary PSD. The patient was admitted hospital due...

IgG4-related systemic diseases are characterized by a diffuse or mass forming inflammatory reaction rich in lymphocytes and IgG4-positive plasma cells (lymphoplasmacytic infiltration), fibrosclerosis of variable organs obliterative phlebitis. They usually involve various including the pancreas, bile duct, gallbladder, salivary gland, retroperitoneum, kidney, lung, prostate. However, most them accompanied autoimmune pancreatitis, good response to steroid treatment is one hallmarks this...

Irritable bowel syndrome (IBS), known as a functional and organic gastrointestinal disorder, is collection of symptoms that occur together generally include pain or discomfort in the abdomen changes movement patterns. Due to limitations conventional treatments, alternative IBS treatments are used by many patients worldwide. Samryungbaekchulsan (SRS), herbal formula, has long been for alleviating diarrhoea-predominant (D-IBS) traditional Korean medicine. Otilonium bromide (OB) an...

Hemostatic clips are widely used to treat gastrointestinal (GI) bleeding and closure of defects in the GI tract.Few data on retrieving hemostatic retained tract available.Patients who had stomach for more than 2 weeks after placement were enrolled.Clips removed with grasping forceps during endoscopy.In 15 patients, a total 45 placed, 31 (68.9%) retained.The median periods clip retention was 105 days (range, 39∼1,383 days).Twenty-seven (87.1%) successfully retrieved forceps, four (12.9%) not...

Introduction: Reflux esophagitis is related to obesity and metabolic syndrome. Nonalcoholic fatty liver disease a hepatic manifestation of the The aim this study was investigate association between erosive reflux diagnosed by ultrasonography. Methods: enrolled subjects were examinees who underwent health check-up examination including esophagogastroduodenoscopy in Myongji Hospital, Goyang, Korea 2004 2011. Erosive according Los Angeles classification. Fatty Results: Of total 14,723 subjects,...