A5057956666- Advanced Glycation End Products research
- Seaweed-derived Bioactive Compounds
- Photoacoustic and Ultrasonic Imaging
- Neuroinflammation and Neurodegeneration Mechanisms
- Thermography and Photoacoustic Techniques
- Regulation of Appetite and Obesity
- Alzheimer's disease research and treatments
- Angiogenesis and VEGF in Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Fatty Acid Research and Health
- Lipid metabolism and biosynthesis
- Biochemical Analysis and Sensing Techniques
- Atherosclerosis and Cardiovascular Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nanoplatforms for cancer theranostics
- Skin Protection and Aging
- Retinal Diseases and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Morinda citrifolia extract uses
- Inflammasome and immune disorders
- Acne and Rosacea Treatments and Effects
- Inflammatory mediators and NSAID effects
- Natural Antidiabetic Agents Studies
- Neurological Disease Mechanisms and Treatments
- Dermatologic Treatments and Research
Kangwon National University
2024-2025
Gachon University
2012-2022
Inha University
2022
Gachon University Gil Medical Center
2017
Abstract During cancer resection surgeries, intraoperative histopathologic examination of the surgical specimen is crucial for tumor margin identification. A conventional frozen‐section analysis requires complex tissue processing, which prolongs surgery and potentially introduces interpretation errors. Here, as a novel approach to label‐free histopathology, high‐speed reflection‐mode ultraviolet photoacoustic microscopy (UV‐PAM) system employing waterproof 1‐axis microelectromechanical...
Obesity-associated metabolic alterations are closely linked to low-grade inflammation in peripheral organs, which macrophages play a central role. Using genetic labeling of myeloid lineage cells, we show that hypothalamic normally reside the perivascular area and circumventricular organ median eminence. Chronic consumption high-fat diet (HFD) induces expansion monocyte-derived macrophage pool arcuate nucleus (ARC), is significantly attributed enhanced proliferation macrophages. Notably,...
Nonalcoholic fatty liver disease (NAFLD), which promotes serious health problems, is related to the increase in nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome and pyroptosis by a high-fat diet (HFD). Whether dieckol (DK), component of Ecklonia cava extracts (ECE), attenuated NAFLD an HFD-induced animal model was evaluated. The expression high mobility group box 1/Toll-like 4/nuclear factor-κB, initiated NLRP3 inflammasome,...
Abstract The physical abrasion of plastics from simple everyday entered the food chain, with associated risks recently emphasized. Although many studies have reported adverse effects microplastics (MPs) on human, reproductive implications continuous exposure to physically abraded polyethylene terephthalate (PET)‐MPs remain unexplored. Ingestion PET‐MPs (size range: 50–100 µm) in mice 5 34 weeks age at an annual intake relevant dose MPs (5 mg week −1 ) significantly impaired male function....
Blood circulation disorders, such as hyperlipidemia and arteriosclerosis, are not easily cured by dietary supplements, but they can be mitigated. Although Ecklonia cava extract (ECE), associated with improving the conditions, there many studies verifying same. In this study, beneficial effect of ECE leaf Ginkgo biloba (GBE), which is a well-known supplement, were first confirmed in diet induced-obese model. Afterwards, 4 phlorotannins isolated from ECE, their inhibitory effects on vascular...
Müller gliosis is a complex process that impairs the ability of retinal glial cells to respond various forms injury or disease, leading damage. Blue light (BL) exposure known cause In this study, we aimed investigate potential DPHC in inhibiting models BL-exposure. We conducted silico binding analysis evaluate CXCR4. Then, developed vitro and vivo experimental assess effects BL on using MIO-M1 zebrafish. Our findings show can suppress BL-exposed zebrafish vivo. molecular docking, identified...
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Abstract: Advanced glycation end products (AGEs) are known to play an important role in the pathogenesis of neurodegenerative diseases, including Parkinson's disease (PD), by inducing protein aggregation and cross-link, formation Lewy body, neuronal death. In this study, we observed that AGE-albumin, most abundant AGE product human PD brain, is synthesized activated microglial cells accumulates extracellular space. AGE-albumin synthesis human-activated distinctly inhibited ascorbic acid...
The primary cilia are evolutionarily conserved microtubule-based cellular organelles that perceive metabolic status and thus link the sensory system to signaling pathways. Therefore, ciliogenesis is thought be tightly linked autophagy, which also regulated by nutrient-sensing transcription factors, such as PPARA (peroxisome proliferator activated receptor alpha) NR1H4/FXR (nuclear subfamily 1, group H, member 4). However, relationship between these factors has not been clearly demonstrated....
It is well known that perivascular fat tissue (PVAT) dysfunction can induce endothelial cell (EC) dysfunction, an event which related with various cardiovascular diseases. In this study, we evaluated whether Ecklonia cava extract (ECE) and pyrogallol-phloroglucinol-6,6-bieckol (PPB), one component of ECE, could attenuate EC by modulating diet-induced PVAT mediated inflammation ER stress. A high diet (HFD) led to increase in the number size white adipocytes PVAT; PPB ECE attenuated those...
Leptin resistance in the hypothalamus has an essential role obesity. Saturated fatty acids such as palmitate bind to Toll-like receptor 4 (TLR4) and lead endoplasmic reticulum (ER) stress leptin resistance. In this study, we evaluated whether extracts of Ecklonia cava would attenuate ER induced by reduce hypothalamic neurons microglia. We added these cells mimic environment high-fat diet which E. phlorotannins—dieckol (DK), 2,7-phloroglucinol-6,6-bieckol (PHB),...
In hyperlipidemia, pyroptosis in endothelial cells (ECs) induces atherosclerosis via the toll-like receptor 4 (TLR4) pathway. We evaluated effects of Ecklonia cava extract (ECE) and pyrogallol-phloroglucinol-6,6-bieckol (PPB) on ECs vascular smooth muscle (VSMCs), which leads to attenuation these dysfunction aorta high-fat-diet (HFD)-fed mice palmitate-treated VSMCs. The expression TLR4 nuclear factor kappa-light-chain-enhancer activated B (NF-κB), induce formation NOD-LRR-and pyrin...
Alcohol is a neurotoxic agent, since long-term heavy ingestion of alcohol can cause various neural diseases including fetal syndrome, cerebellar degeneracy and alcoholic dementia. However, the molecular mechanisms alcohol-induced neurotoxicity are still poorly understood despite numerous studies. Thus, we hypothesized that activated microglial cells with elevated AGE-albumin levels play an important role in promoting neurodegeneration. Our results revealed activation neuronal damage were...
Ecklonia cava (E. cava) can alleviate diet-induced obesity in animal models, and phlorotannins contained E. help prevent hypertrophy-induced adipocyte differentiation. Receptor for advanced glycation end-products (RAGE) is well known to induce hypertrophy of visceral fat trigger inflammation substantially. While the relationship between RAGE has been well-characterized, few studies describe effects phlorotannin on RAGE. In this study, we investigated anti-obesity...
Disruptions of the Treg/Th17 cell balance and gut barrier function are associated with endothelial dysfunction. Dieckol (DK) obtained from Ecklonia cava E. extract (ECE) decreases blood pressure by reducing inflammation; however, it has not been elucidated whether DK or ECE modulates balance, changes epithelial barrier, We evaluated effects on in intestine aorta, regard to dysfunction, using spontaneously hypertensive rat (SHR) model. The level Th17 cells increased that Treg decreased SHRs...
A holy grail of curing neurodegenerative diseases is to identify the main causes and mechanisms underlying neuronal death. Many studies have sought these targets in a wide variety ways, but more important task critical molecular their origins. Potential include advanced glycation end products (AGEs) that can promote cell death, thereby contributing disorders such as Alzheimer disease or Parkinson disease. In this study, we showed AGE-albumin (glycated albumin) synthesized microglial cells...
Much evidence indicates receptor for advanced glycation end products (RAGE) related inflammation play essential roles during aging. However, the majority of studies have focused on (AGEs) and not other RAGE ligands. In present study, authors evaluated whether accumulation ligands binding intensities between its differ in kidney, liver, skeletal muscle aging.In C57BL/6 N mice aged 12 weeks, months, 22 accumulation, ligands, activated macrophage infiltration, M1/M2 expression,...
Ecklonia cava (E.cava) can alleviate vascular dysfunction in diseases associated with poor circulation. E. contains various polyphenols different functions, but few studies have compared the effects of these polyphenols. Here, we comparatively investigated four major compounds present an ethanoic extract cava. These were isolated and their examined on monocyte-associated inflammation dysfunctions. Pyrogallol-phloroglucinol-6,6-bieckol (PPB) significantly inhibited monocyte migration vitro by...
Obesity is associated with systemic chronic inflammation, and it induces central leptin resistance which blocks the appetite-suppressing effect of in adipocytes. In present study, we evaluated effects Ecklonia cava extract (ECE), contained rich phlorotannins, on inflammation adipose tissue a diet-induced obese model. Effects ECE fat deposition, M1/M2 macrophage, T-cell infiltrations were investigated, SOCS3 also measured tissue. Furthermore, attenuated expression inflammation-related...
Rosacea is a skin inflammatory condition accompanied by cutaneous signs such as oedema, flushing, erythema, telangiectasia and pustules. Generally, rosacea triggered ultraviolet B (UVB) exposure. When exposed to UVB, epidermis thickens produces elevated levels of pro-inflammatory cytokines, especially keratinocyte-related VEGF, potent angiogenic factor. The upregulations VEGF expression its secretion promote the formation new blood vessels exacerbates rosacea. In this study, radiofrequency...
Hyperlipidemia induces vascular smooth muscle cell (VSMC) proliferation and phenotype switching from contractile to synthetic. This process is involved in arterial remodeling via the chemokine ligand 5 (CCL5)/chemokine receptor (CCR5) pathway. Arterial related atherosclerosis or intimal hyperplasia. The purpose of this study was evaluate whether pyrogallol-phloroglucinol-6,6-bieckol (PPB) E. cava reduces VSMC CCL5/CCR5 expression, phenotypic alterations were evaluated using a model exposed...
// Roshini Arivazhagan 1 , Jaesuk Lee Delger Bayarsaikhan Peter Kwak Myeongjoo Son 1, 2 Kyunghee Byun Ghasem Hosseini Salekdeh 3, 4 and Bonghee Center for Genomics Proteomics, Gil Ya Cancer Diabetes Institute, Gachon University, Incheon, Republic of Korea Department Anatomy Cell Biology, University Graduate School Medicine, 3 Molecular Systems Science Research Center, Royan Institute Stem Biology Technology, ACECR, Tehran, Iran Sciences, Macquarie Sydney, New South Wales, Australia...