A5003276471- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Animal Vocal Communication and Behavior
- Cardiovascular Disease and Adiposity
- Animal Behavior and Reproduction
- Immune Cell Function and Interaction
- Marine animal studies overview
- Regulation of Appetite and Obesity
- Fish Ecology and Management Studies
- Avian ecology and behavior
- Lipid metabolism and biosynthesis
- Pancreatic function and diabetes
- Transportation Safety and Impact Analysis
- Structural Response to Dynamic Loads
- Metabolomics and Mass Spectrometry Studies
- Tryptophan and brain disorders
- Advanced Proteomics Techniques and Applications
- High-Velocity Impact and Material Behavior
- Species Distribution and Climate Change
- Land Use and Ecosystem Services
- IL-33, ST2, and ILC Pathways
- Protein purification and stability
- Environmental Changes in China
- Inflammasome and immune disorders
- Diet, Metabolism, and Disease
National Institute of Biological Resources
2023
Seoul National University
2012-2022
Seoul National University of Science and Technology
2021-2022
Yonsei University
2020
Tissue inflammation is a key factor underlying insulin resistance in established obesity. Several models of immuno-compromised mice are protected from obesity-induced resistance. However, it unanswered whether triggers systemic or vice versa The purpose this study was to assess these questions.We fed high-fat diet (HFD) wild-type and three different mouse (lymphocyte-deficient Rag1 knockout, macrophage-depleted, hematopoietic cell-specific Jun NH(2)-terminal kinase-deficient mice) measured...
Firmicutes and Bacteroidetes, 2 major phyla of gut microbiota, are involved in lipid bile acid metabolism to maintain systemic energy homeostasis host. Recently, accumulating evidence has suggested that dietary changes promptly induce the alteration abundance both Bacteroidetes obesity its related metabolic diseases. Nevertheless, roles on such disease states remain unclear. The aim this study was determine effects antibiotic-induced depletion dysregulation obesity. Treatment C57BL/6J mice...
Systemic low-grade chronic inflammation has been intensively investigated in obese subjects. Recently, various immune cell types, such as macrophages, granulocytes, helper T cells, cytotoxic and B have implicated the pathogenesis of adipose tissue inflammation. However, roles invariant natural killer cells (iNKT cells) regulation iNKT activity are not thoroughly understood. Here, we demonstrated that were decreased number Interestingly, CD1d, a molecule involved lipid antigen presentation to...
Orosomucoid (ORM), also called alpha-1 acid glycoprotein, is an abundant plasma protein that immunomodulator induced by stressful conditions such as infections. In this study, we reveal Orm selectively in the adipose tissue of obese mice to suppress excess inflammation otherwise disturbs energy homeostasis. Adipose levels were elevated metabolic signals, including insulin, high glucose, and free fatty acid, well proinflammatory cytokine tumor necrosis factor-alpha, which found increased...
Obesity-associated metabolic alterations are closely linked to low-grade inflammation in peripheral organs, which macrophages play a central role. Using genetic labeling of myeloid lineage cells, we show that hypothalamic normally reside the perivascular area and circumventricular organ median eminence. Chronic consumption high-fat diet (HFD) induces expansion monocyte-derived macrophage pool arcuate nucleus (ARC), is significantly attributed enhanced proliferation macrophages. Notably,...
Obesity is closely associated with increased adipose tissue macrophages (ATMs), which contribute to systemic insulin resistance and altered lipid metabolism by creating a pro-inflammatory environment. Very low-density lipoprotein receptor (VLDLR) involved in uptake storage. However, whether via VLDLR affects obesity-induced inflammatory responses not well understood. Here we show that elevated expression ATMs promotes inflammation glucose intolerance obese mice. In macrophages, VLDL...
Accumulating evidence suggests that subcutaneous and visceral adipose tissues are differentially associated with metabolic disorders. In obesity, tissue is beneficial for homeostasis because of repressed inflammation. However, the underlying mechanism remains unclear. Here, we demonstrate γ-aminobutyric acid (GABA) sensitivity crucial in determining fat depot-selective macrophage (ATM) infiltration obesity. diet-induced GABA reduced monocyte migration inguinal (IAT), but not epididymal...
One method of understanding landscape pattern changes is through an land use/land cover (LULC) changes, which are closely related to changes. Previous studies have monitored LULC across North Korea but did not consider at a local scale. Using multiple products construct sample points, the was classified using random-forest algorithm and Landsat satellite dataset. The overall accuracy classification 97.66 ± 1.36%, Kappa coefficient 0.95 0.03. Based on results, indices were used quantify...
Dysregulation of lipid metabolism is a key feature metabolic disorder related to side effects antipsychotic drugs. Here, we investigated the molecular mechanism by which second-generation atypical drugs (AAPDs) affect hepatic in liver. AAPDs augmented accumulation activating expression sterol regulatory element-binding protein (SREBP) transcription factors, with subsequent induction downstream target genes involved and cholesterol synthesis hepatocytes. We confirmed direct involvement SREBPs...
SREBP1c is a key transcription factor for de novo lipogenesis. Although expressed in pancreatic islets, its physiological roles β-cells are largely unknown. In this study, we demonstrate that regulates β-cell compensation under metabolic stress. expression level was augmented islets from obese and diabetic animals. β-cells, activation promoted the of cell cycle genes stimulated proliferation through novel target gene, PAX4. Compared with SREBP1c+/+ mice, SREBP1c−/− mice showed glucose...
This paper addresses the protection capability of a runway pavement by executing field blast test on an airfield subjected to loading from CBU (cluster bomb unit), and confirming numerical simulation warhead penetration form damage. The CBU’s applies BAP 100 air-to-ground munition in similar scale. Penetration depth is calculated formula which incorporates terminal speed free-falling cluster dispersed 20 km above ground. According result calculation, 33 cm surface pavement. was conducted...
Abstract Anti‐predatory strategies of birds are diverse and may include predator‐specific alarm calls. For example, oriental tit ( Parus minor ) parents can distinguish snakes from other predators produce snake‐specific referential vocalizations ("jar" call) when a snake poses threat to their nest. The “jar” call has very specific function induce fledging nestlings close age. This reaction ensures nestlings' survival in natural encounters with that capable entering nest cavities kill entire...
Phosphorylation and glycosylation are two of the most important widespread post-translational modifications(PTMs) in an organism. Proteomics analysis PTMs has been challenged by low stoichiometry modified proteins andsuppression effects high abundance proteins, typically no-functional house-keeping proteins. In this study, a novel methodwas applied for not only isolating PTM peptides from intact but also concurrently characterizing glyco- phosphoproteomeusing electrostatic repulsion...
Obesity has become a pandemic that threatens the quality of life and discovering novel therapeutic agents can reverse obesity obesity-related metabolic disorders are necessary. Here, we aimed to identify new anti-obesity using phenotype-based approach. We performed image-based high-content screening with fluorogenic bioprobe (SF44), which visualizes cellular lipid droplets (LDs), initial hit compounds. A structure-activity relationship study led us yield bioactive compound SB1501, reduces...
Abstract This paper discusses a field test of airfield pavement under cluster bomb unit (CBU) blast load and study repair method upon the examination damage geometry. Cluster shows similar level to that typically known air-to-ground munition, penetration depth was calculated using empirical formulae with terminal velocity during free fall following an explosion dispersion 20km above ground. Based on calculations, executed assuming 33cm for concrete surface. The slab site casted in circular...
Adipose tissue plays a central role in regulating dynamic crosstalk between tissues and organs. A detailed description of molecules that are differentially expressed upon changes adipose mass is expected to increase our understanding the molecular mechanisms underlie obesity related metabolic co-morbidities. Our previous studies suggest possible link endophilins (SH3Grb2 proteins) body weight. To explore this further, we sought assess distribution endophilin A2 (EA2) human experimental...
Observations and video documentation of interactions between animals living in dens, cavities, other enclosed spaces are difficult, but they play an important role field biology, ecology, conservation. For example, bird parents visiting nests feeding their nestlings may provide crucial information for testing ecological hypotheses easily attract attention participants citizen-science conservation projects. Because the nest concealment cavity-nesting birds, behaviors can only be studied by...
In mammals, white adipose tissues are largely divided into visceral epididymal tissue (EAT) and subcutaneous inguinal (IAT) with distinct metabolic properties. Although emerging evidence suggests that subpopulations of stem cells (ASCs) would be important to explain fat depot differences, ASCs two depots have not been comparatively investigated. Here, we characterized heterogeneous examined the effects intrinsic micro-environmental factors on ASC features. We demonstrated in EAT IAT...
Liquid chromatography based mass spectrometry (LC-MS) is a key technology for analyzing highly complex anddynamic proteome samples. With accurate and sensitive LC-MS analysis of samples, efficient dataprocessing another critical issue to obtain more information from data. A typical proteomic data processing starts withprotein database search engine which assigns peptide sequences MS/MS spectra finds proteins. Although several searchengines, such as SEQUEST MASCOT, have been widely used,...