A5100323627- Genetic factors in colorectal cancer
- Technology and Data Analysis
- Extracellular vesicles in disease
- Physical Activity and Health
- RNA Research and Splicing
- Nutrition and Health in Aging
- Bioinformatics and Genomic Networks
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Mobile Ad Hoc Networks
- Health and Wellbeing Research
- Diverse Approaches in Healthcare and Education Studies
- Health disparities and outcomes
- Energy Efficient Wireless Sensor Networks
- Gastrointestinal Bleeding Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Gastric Cancer Management and Outcomes
- Systemic Lupus Erythematosus Research
- Food Quality and Safety Studies
- Evolutionary Algorithms and Applications
- Transportation Safety and Impact Analysis
- Wireless Networks and Protocols
- Soft Robotics and Applications
- Body Composition Measurement Techniques
- Ergonomics and Musculoskeletal Disorders
Seoul National University
2014-2025
Gachon University Gil Medical Center
2016-2024
University of Wisconsin–Madison
2023-2024
Gachon University
2016-2023
Georgia Institute of Technology
2012-2023
Kyungpook National University
2023
Chungbuk National University
2020-2023
The Wallace H. Coulter Department of Biomedical Engineering
2023
Emory University
2023
Bio-Medical Science (South Korea)
2023
Although information systems (IS) problem solving involves knowledge of both the IS and application domains, little attention has been paid to role domain knowledge. In this study, which is set in context conceptual modeling, we examine effects on different types schema understanding tasks: syntactic semantic comprehension tasks schema-based problem-solving tasks. Our thesis was that while important all such tasks, contingent upon type task under investigation. We use theory cognitive fit...
Background: Modeling of human arrhythmias with induced pluripotent stem cell–derived cardiomyocytes has focused on single-cell phenotypes. However, are the emergent properties cells assembled into tissues, and impact inherited arrhythmia mutations tissue-level heart tissue not been reported. Methods: Here, we report an optogenetically based, engineered model catecholaminergic polymorphic ventricular tachycardia (CPVT), caused by mutation cardiac ryanodine channel triggered exercise. We...
The interactions of sex, age, season, and habitual physical activity were examined in 41 male 54 female Japanese age 65–83 yr, using a pedometer/accelerometer that determined step counts amounts (<3 >3 metabolic equivalents [METs]) throughout each 24-hr period for an entire year. All 3 measures greater men than women. In women, was negatively correlated with count <3 METs, but men, it METs. Irrespective sex or all variables low the winter, peaking spring autumn. summer, matched...
Objectives To relate 5‐year lean tissue loss to habitual physical activity of elderly adults. Design Longitudinal. Setting Community Nakanojo. Participants Community‐living Japanese aged 65 84 (200 men, 268 women). Measurements Daily 24‐hour pedometer/accelerometer data, collected continuously for 5 years, were categorized into quartiles. Bioelectrical impedance measurements body mass taken annually. A sarcopenia threshold was defined arbitrarily as an appendicular mass/height 2 more than 1...
Significance Recordings from Pacinian corpuscles in the 1960s showed that touch elicits symmetric activation followed by rapid adaptation. Sinusoidal stimulation resulted frequency doubling within a sensitive band, suggesting these receptors function as frequency-tuned vibration sensors. At time, surrounding lamellar capsule was proposed to generate response dynamics acting mechanical filter. However, similar have since been seen many other mechanoreceptors, leading controversy over...
Recently, the capsule endoscope can be widely used for diagnosis of digestive organs. It is passively moved by peristaltic waves gastro-intestinal tract and thus has some limitations doctor to get image organ diagnose more thoroughly. As a solution these problems, therefore, locomotive mechanism endoscopes being developed. Our proposed capsule-type microrobot synchronized multiple legs that are actuated linear actuator two mobile cylinders inside capsule. By novel kinematic relation between...
The Physical Activity Questionnaire for Elderly Japanese (PAQ-EJ) is a self-administered physical activity questionnaire elderly Japanese; the authors report here on its repeatability and direct indirect validity. Reliability was assessed by repeat administration after 1 month. Direct validation based accelerometer data collected every 4 s month in 147 individuals age 65–85 years. Indirect against 10-item Barthel index (activities of daily living [ADL]) completed 3,084 65–99 test–retest...
When a software product is composed of dozens or even hundreds components with complicated dependency relationship among each other, one component's change can affect lots other components' behavior. Sometimes, therefore, the stabilization job multiple updated drives people who are responsible for integration and release into an hell. To avoid this kind hell, we established procedure which encourages developers frequent small releases. We also created automated system continuously runs...
Abstract While altered TP53 is the most frequent mutation in gastric cancer (GC), its association with molecular or clinical phenotypes (e.g., overall survival, disease-free survival) remains little known. To that end, we can use genome-wide approaches to identify genes significantly related mutated . Here, identified significant differences outcomes, as well phenotypes, across specific GC tumor subpopulations, when combining other signaling networks, including WNT and NRXN1, CTNNB1,...
Objectives To examine dose/response relationships between habitual physical activity and bone health in the elderly. Design Longitudinal. Setting Community of Nakanojo. Participants Community‐living Japanese aged 65 to 84 (212 men, 284 women). Measurements Daily 24‐h pedometer/accelerometer data were collected continuously for 5 years. A quantitative calcaneal osteosonic index ( OSI ) was determined annually. Results Year‐end values higher those with greater daily step counts especially a...
Oligodendrocyte development is tightly controlled by extrinsic signals; however, mechanisms that modulate cellular responses to these factors remain unclear. Six-transmembrane glycerophosphodiester phosphodiesterases (GDEs) are emerging as central regulators of differentiation via their ability shed glycosylphosphatidylinositol (GPI)-anchored proteins from the cell surface. We show here GDE3 controls pace oligodendrocyte generation negatively regulating precursor (OPC) proliferation....
// Hae Ryung Chang 1, 2, * , Seungyoon Nam 3, Jinhyuk Lee 4, 5, Jin-Hee Kim 6, Rim Jung 1 Hee Seo Park 7 Sungjin 3 Young Zoo Ahn Iksoo Huh 8 Curt Balch 9 Ja-Lok Ku 10 Garth Powis 11 Taesung Jin-Hyun Jeong 6 Yon Hui 12 New Experimental Therapeutics Branch, National Cancer Center of Korea, Goyang-si, Republic Korea 2 Research Institute Women's Health, Sookmyung University, Seoul, College Medicine, Gachon Incheon, 4 Korean Bioinformation Center, Bioscience and Biotechnology, Daejeon, 5...
To explore extracellular vesicle microRNAs (EV miRNAs) and their target mRNAs in relation to diabetic kidney disease (DKD), we performed paired plasma urinary EV small RNA sequencing (n = 18) patients with type 2 diabetes DKD 5) healthy subjects 4) metabolic network analyses using our own miRNA public mRNA datasets. We found 13 common differentially expressed miRNAs both fluids 17 mRNAs, including RRM2, NT5E, UGDH. Because succinate dehydrogenase B was suggested interact proteins encoded by...
The role of heat shock protein 60 (HSP60), a mitochondrial chaperone, in tumor progression or its anti-tumor effects remains controversial. This study aimed to confirm the possibility using HSP60 as prognostic marker patients with colorectal cancer (CRC), considering TNM classification for precise prediction. expression increased differentiation and p53 mutations patients. However, compared high expression, low had event-free survival disease-specific hazard ratios (HRs) 1.42 1.69,...
The incidence of colorectal cancer (CRC) is increasing worldwide. 8-hydroxy-2′-deoxyguanosine (8-OHdG), one the most prevalent DNA alterations, known to be upregulated in several carcinomas; however, 8-OHdG has not been used predict prognosis patients with CRC. We aimed determine levels CRC using immunohistochemistry and conducted a survival analysis according pathological stage. 5-year event-free (EFS) disease-specific (DSS) hazard ratios (HRs) low subgroup were 1.41 (95% confidence...
<b><i>Background:</i></b> An age-related decrease in functional capacity is consistently reported, but it not related to a worsening of health-related quality life (HRQOL) or psychological adjustment. A poor and HRQOL have been associated with anxiety depression, the possible causal nature direction relationship remain be explored using long-term longitudinal data. <b><i>Objective:</i></b> The purpose this study was examine changes capacity,...