A5056578032- Microbial metabolism and enzyme function
- Metal-Catalyzed Oxygenation Mechanisms
- Porphyrin Metabolism and Disorders
- Photosynthetic Processes and Mechanisms
- Adipose Tissue and Metabolism
- Toxic Organic Pollutants Impact
- Diverse Approaches in Healthcare and Education Studies
- Health and Wellbeing Research
- Healthcare Education and Workforce Issues
- Ocular Surface and Contact Lens
- ATP Synthase and ATPases Research
- Hemoglobin structure and function
- Birth, Development, and Health
- Zebrafish Biomedical Research Applications
- Education and Learning Interventions
- 3D Printing in Biomedical Research
- Surfactants and Colloidal Systems
- Hydrogels: synthesis, properties, applications
- Pesticide Exposure and Toxicity
- Galectins and Cancer Biology
- Retinal Diseases and Treatments
- Carcinogens and Genotoxicity Assessment
- Lipid metabolism and disorders
- Workplace Health and Well-being
- Glaucoma and retinal disorders
Seoul National University of Science and Technology
2014-2024
University of Central Florida
2012
University of Mississippi Medical Center
2007-2011
In-Q-Tel
2011
State Street (United States)
2007
Respiration, photosynthesis, and metabolism require the transfer of electrons through between proteins over relatively long distances. It is critical that this electron (ET) occur with specificity to avoid cellular damage, at a rate sufficient support biological activity. A multistep hole hopping mechanism could, in principle, enhance efficiency long-range ET as it does organic semiconductors. To explore possibility, two different reactions same distance within protein complex diheme enzyme...
Persistent organic pollutants (POPs) are lipid-soluble toxins that not easily degraded; therefore, they accumulate in the environment and human body. Several studies have indicated a correlation between POPs metabolic diseases; however, their effects on mitochondria as central organelle cellular metabolism usage of functional markers for disease barely understood. In this study, zebrafish model system was exposed to two subclasses POPs, organochlorine pesticides (OCPs) polychlorinated...
Tobacco etch virus (TEV) protease is a 27‐kDa catalytic domain of the polyprotein nuclear inclusion (NIa) in TEV, which recognizes specific amino acid sequence ENLYFQG/S and cleaves between Q G/S. Despite its substrate specificity, use limited by autoinactivation through self‐cleavage poor solubility during purification. It was previously reported that T17S/N68D/I77V mutations improve yield TEV S219 provide protection against self‐cleavage. In this study, we isolated proteases with S219N...
The degree of protonation contact lens materials is affected by the surrounding pH environment, due to different pKa values. swelling ionic lenses generally controlled these factors which determines physical properties lenses. purpose this study was evaluate dependence etafilcon A and non-ionic hilafilcon B were used in study. diameter, refractive power, equilibrium water content (EWC), amounts freezable-free (Wff), freezable-bound (Wfb) non-freezable (Wnf) at each condition measured. power...
The effects of replacing the axial methionine ligand type 1 copper site with leucine on structure and function amicyanin have been characterized. crystal structures oxidized reduced forms protein reveal that is now tricoordinate no ligand, coordination distances for two ligands provided by histidines are significantly increased. Despite these structural changes, absorption EPR spectra M98L only slightly altered still consistent a typical site. oxidation-reduction midpoint potential (E(m))...
Mitochondrial metabolism plays a crucial role in insulin resistance and secretion type 2 diabetes mellitus (T2D). Some studies have focused on how Cassia tora extracts affect hyperglycemia. However, the effects of mitochondrial dysfunction associated with not been well explained. In this study, well-known effective compounds extracted from using 70% ethanol were administered to high-fat diet (HFD) fed mouse examine ethanolic (CSEE) pancreas. Furthermore, we examined CSEE regulates basal...
Ophthalmic hydrogels are known for their hydrophilicity, which although beneficial eye comfort, also predisposes them to absorbing external compounds, including potentially harmful phthalates. This study investigated the absorption of dimethyl phthalate and diethyl phthalate, plasticizers found in numerous consumer products by ophthalmic hydrogels. The results demonstrate differential capacities between two hydrogels, attributed distinct compositions. interaction phthalates is be...
Contact lens materials include polymers that are ionized in the ocular pH condition and susceptible to protein deposition due their surface characteristics. Herein, we investigated effect of electrostatic state contact material on level using hen egg white lysozyme (HEWL) bovine serum albumin (BSA) as model proteins etafilcon A hilafilcon B materials. Only HEWL showed a statistically significant pH-dependency (p < 0.05); increased with pH. positive zeta potential at acidic pH, while BSA...
Amicyanin is a type 1 copper protein that serves as an electron acceptor for methylamine dehydrogenase (MADH). The site of interaction with MADH "hydrophobic patch" amino acid residues including those comprise "ligand loop" provides three the four ligands. Three prolines are present in this region. Pro94 ligand loop was previously shown to strongly influence redox potential amicyanin but not affinity or mechanism transfer (ET). In study Pro96 mutated. P96A and P96G mutations did affect...
Benzalkonium chloride (BKC) is a cationic surfactant used as component in ophthalmic eye drops. The effects of BKC on the and simple binding contact lens surface have been reported other studies. However, exact value affinity surfaces its physical properties lenses not studied. Here, toward two types lenses, those with wetting agent polyvinylpyrrolidone (PVP) without, was calculated. In addition, refractive power, UV–vis transmittance, angle, water content, base curve, diameter after...
Lysozyme is an antibacterial enzyme that found in most of body fluids. tears plays a primary role protecting eye from harmful environments; if lysozyme degraded or inhibited, eyes are likely to be more vulnerable bacterial infection. In this study, activity was evaluated according varying concentrations heavy metals, copper, zinc, cobalt and manganese light metal, calcium frequently airborne particulate matters assayed using dyequenching substrate, Micrococcus lysodeikticus. Less...
Type 2 diabetes (T2D) is characterized by defects in insulin action to target tissues, resulting hyperglycemia, resistance, and mitochondrial dysfunction. The eye one of the organs susceptible T2D, but knowledge regarding dysfunction eyes after hyperglycemia T2D based mainly on epidemiological evidence, with little experimental data. Persistent organic pollutants (POPs) are known as endocrine-disrupting chemicals associated uncontrolled glucose lipid metabolism, leading onset diabetes. To...
The purpose of this study is to assess the quantity and quality myopia related articles from 2001 2021 using bibliometric methods. number published citations, correlation analysis between gross domestic product (GDP) annual publication citations was investigated. proportion East Asia accounted for 55.28% in 2021. researchers China most on during 2021, followed by Japan South Korea. Korea showed an exponential increase with strong positive GDP. All 3 countries are mainly researching...
목적: 본 연구는 안경사의 직무스트레스의 요인과 우울증상의 정도를 분석하여 상관관계를 파악하였다. 방법: 수도권에 종사하는 153명의 안경사를 무작위로 선별하여 설문조사를 실시하였다. 배포된 설문지 중 주요 변수에 대한 응답이 부실한 설문 4부를 제외한 149부의 설문을 분석하였다. 대상자의 정도는 Beck 우울 척도(Beck Depression Inventory-II: BDI-II)로, 한국인 직무스트레스 측정도구(Korean Occupational Stress Scale: KOSS)를 이용하여 SPSS Statistic 18.0로 결과: 연구 대상자 우울증상이 있는 집단이 18.8%, 없는 81.2%로 나타났다. 우울증상은 성별, 주관적 건강 상태 및 경제 상태와 유의한 차이를 보였으며 평균 점수는 군이 군에 비해 총점을 포함한 모든 항목에서 높게 직무불안정성을 항목과 통계적으로 유의하였다. 하위 BDI-II에 따른 우울증상 점수와의 분석한 결과, 총점, 조직체계,...
Abstract Cassia tora is an annual herb, which has pharmacological effects such as antioxidant, hypolipidemic, and antidiabetic effects. Accordingly, its effect on diabetes been well-studied. However, it unclear whether mitochondrial dysfunction associated with diabetes. In this study, the of emodin rhein in C. seed ethanolic extract (ER/CSEE) retinal function were examined high-fat diet (HFD)-fed mice. HFD-fed mice exhibited decreased followed by compensatory increase expression levels...