A5100321423- Cancer Mechanisms and Therapy
- Mechanisms of cancer metastasis
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Cardiac Ischemia and Reperfusion
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Adipokines, Inflammation, and Metabolic Diseases
- Fatty Acid Research and Health
- Kruppel-like factors research
- Eicosanoids and Hypertension Pharmacology
- Metastasis and carcinoma case studies
- Anesthesia and Neurotoxicity Research
- Mitochondrial Function and Pathology
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- CAR-T cell therapy research
- Peroxisome Proliferator-Activated Receptors
- Nitric Oxide and Endothelin Effects
- Luminescence Properties of Advanced Materials
- Lymphoma Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Cytokine Signaling Pathways and Interactions
- Circular RNAs in diseases
- Chronic Lymphocytic Leukemia Research
Second Hospital of Shandong University
2014-2023
Xi'an Honghui Hospital
2023
Xi'an Jiaotong University
2023
Affiliated Hospital of Qingdao University
2021
Qingdao University
2021
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2018
Anhui Medical University
2018
Wuhan Puai Hospital
2015
Shandong University
2015
Wuhan University
2007-2010
Irisin is a newly discovered myokine that links exercise with metabolic homeostasis. It involved in modest weight loss and improves glucose intolerance. However, the direct effects mechanisms of irisin on vascular endothelial cells (ECs) are not fully understood. In current study, we demonstrated promoted Human Umbilical Vein Endothelial Cell (HUVEC) proliferation. was further this pro-proliferation effect mediated by irisin-induced activation extracellular signal–related kinase (ERK)...
Irisin, a newly discovered myokine, is considered as promising candidate for the treatment of metabolic disturbances and cardiovascular diseases. In present study, we used two animal models, apolipoprotein E-deficient mice fed on high-cholesterol diet mouse carotid partial ligation model to test anti-atherosclerotic effect irisin. Irisin (0.5 μg/g body weight/day) significantly reduced severity aortic atherosclerosis in suppressed neointima formation model. It was associated with decreased...
As a link between exercise and metabolism, irisin is assumed to be involved in increased total body energy expenditure, reduced weight, insulin sensitivity. Although our recent evidence supported the contribution of vascular endothelial cell (ECs) proliferation apoptosis, further research involvement angiogenesis ECs was not conclusive. In current study, it found that promoted Human Umbilical Vein Endothelial Cell (HUVEC) via increasing migration tube formation, attenuated chemically-induced...
Irisin is a newly discovered myokine that has been considered promising candidate for the treatment of cardiovascular disease through improving endothelial function. However, little known about role irisin in progression atherosclerosis.We used carotid partial ligation model apolipoprotein E-deficient mice fed on high-cholesterol diet to test anti-atherosclerosis effect irisin. significantly suppressed neointima formation. It was associated with increased cell proliferation. In addition,...
Abstract Background Pulmonary hypertension (PH) is a life-threatening disease characterized by pulmonary vascular remodeling, right ventricular hypertrophy and failure. So far no effective treatment exists for this disease; hence, novel approaches are urgently needed. The aim of the present research was to observe effect mesenchymal stromal cell derived exosomes reveal mechanism. Methods Monocrotaline (MCT)-induced PH in rats hypoxia-induced damage model were established, respectively....
Cardiotonic pills (CP) is a compound Chinese medicine widely used in China, as well other countries, for the treatment of cardiovascular disease. However, limited data are available regarding mechanism action CP on myocardial function during ischemia-reperfusion (I/R) injury. In this study, we examined effect I/R-induced coronary microcirculatory disturbance and damage. Male Sprague-Dawley rats were subjected to left anterior descending branch occlusion 30 min followed by reperfusion with or...
Objectives Research on the relationship between inflammatory biomarkers and malignant tumors has become a hotspot. Many studies have demonstrated that neutrophil‐lymphocyte ratio ( NLR ), platelet‐lymphocyte PLR red blood cell distribution width RDW ) could act as independent prognostic indicators for several solid tumors. This study aimed to evaluate clinical implications of pretreatment biomarkers, including , in prostate cancer PC a). Methods A total 226 patients who were diagnosed at our...
An NIR-emitting MgGeO 3 :Mn 2+ ,Yb 3+ persistent phosphor chargeable with red light has been developed. The features of red-light charging and NIR luminescence make this hold great potential for biomedical imaging optical data storage.
CD19-chimericantigen receptor (CAR) modified T cells (CD19-CAR cells) have been well documented to possess potent anti-tumor properties against CD19-expressingleukemia cells. As a traditional medicine, metformin has widely used treat type II diabetes mellitus and more recently become candidate for the treatment of cancer. However, no report revealed direct effect on CD19-CAR cell biological function its underling mechanisms.The purpose this research was explore mechanisms involved.CD19-CAR...
Supplementation of L-arginine, a nitric oxide precursor, during the late phase myocardial ischemia/reperfusion increases myocyte apoptosis and exacerbates injury, but underlying mechanism is unclear. During ischemia/reperfusion, endothelial cells precedes that cardiomyocyte. Tumor necrosis factor-α (TNF) production increased which may exacerbate injury by inducing cell apoptosis. We postulated L-arginine TNF-induced enhancing peroxynitrite-mediated nitrative stress. Cultured human umbilical...
Nephrotoxicity is a frequent severe side effect of cisplatin chemotherapy, limiting its clinical use despite being one the most potent chemotherapy drugs. Dihydromyricetin highly abundant compound purified from leaves Ampelopsis grossedentata. Previous studies have demonstrated anti-inflammatory and antioxidative effects both in vitro vivo, but little known about on cisplatin-induced nephrotoxicity underlying mechanisms. In present study, we investigated potential renoprotective found that...
Paris polyphylla var. yunnanensis (PPVY), a Chinese herb, has long been used for cancer treatment, and its steroidal saponins are suggested to exert an anti-tumor activity, however, the underlying mechanism is incompletely understood their effect on bladder (BC) remains unknown. The present study thus designed address these issues.Total were extracted with ethanol from PPVY treat BC cells (HT1197 J82 carrying mutant p53). Gene expression was determined using qPCR immunoblotting cell cycle...
The present study aimed to investigate whether co-administration of mesenchymal stromal cells (MSC) and linezolid (LZD) into a rabbit model methicillin-resistant Staphylococcus aureus (MRSA)-infected pneumonia would bring synergistic therapeutic effect. Human umbilical cord-derived MSCs (hUMSCs) were isolated characterized. A was constructed by delivering 1 × 1010 CFU MRSA via bronchoscope the basal segment lower lobe right lung. Through analyzing vital sign, pulmonary auscultation, SpO2,...
It is critical to regulate the senescence-associated secretory phenotype (SASP) due its effect on promoting malignant phenotypes and limiting efficiency of cancer therapy. In this study, we demonstrated that marchantin M (Mar-M, a naturally occurring bisbibenzyl) suppressed pro-inflammatory SASP components which were elevated in chemotherapy-resistant cells. Mar-M treatment attenuated pro-tumorigenic effects enhanced survival drug-resistant mouse models. No toxicity was detected normal...
Multiple GLP-1-derived therapeutics are clinically used to treat type 2 diabetes and obesity. However, the underlying mechanism of how these drugs regulate body weight obese patients remains incompletely understood. Here, we report that lipolysis effects GLP-1 on β cells can depend its induced expression fibronectin III domain containing 5 (FNDC5). The transmembrane FNDC5 is a precursor recently identified hormone irisin possesses range bioactivities, including anti-obesity anti-diabetes. We...