A5102899939- Polymer Surface Interaction Studies
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Pickering emulsions and particle stabilization
- Advanced Polymer Synthesis and Characterization
- Nanoplatforms for cancer theranostics
- NF-κB Signaling Pathways
- Nanoparticle-Based Drug Delivery
- Insect Pest Control Strategies
- Antimicrobial Peptides and Activities
- Quinazolinone synthesis and applications
- Supramolecular Self-Assembly in Materials
- Insect and Pesticide Research
- Mosquito-borne diseases and control
- Hydrogels: synthesis, properties, applications
- Inflammasome and immune disorders
- Insect-Plant Interactions and Control
- Graphene and Nanomaterials Applications
- Drug-Induced Hepatotoxicity and Protection
- Electrohydrodynamics and Fluid Dynamics
- Immune cells in cancer
- Advancements in Transdermal Drug Delivery
- Laser-Ablation Synthesis of Nanoparticles
- Membrane Separation Technologies
- Retinoids in leukemia and cellular processes
SUNY Upstate Medical University
2020-2023
Traditional Chinese Medicine Hospital of Kunshan
2021
Nanjing University of Chinese Medicine
2021
Shanghai University of Traditional Chinese Medicine
2021
Second Hospital of Shandong University
2019
Nankai University
2013-2018
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2014-2018
Proteinosomes are a type of protein-based spherical capsules, which have potential applications in drug delivery, cell imaging, gene expression, and biocatalysis. In this research, novel approach to the fabrication proteinosomes entirely composed protein molecules based on self-assembly supramolecular protein-polymer conjugate is proposed. A was prepared by mixing βCD-modified bovine serum albumin (BSA) adamantane-terminated poly(N-isopropylamide) (Ad-PNIPAM) aqueous solution. The BSA-PNIPAM...
Natural products are a major source for cancer drug development. NK cells critical component of innate immunity with the capacity to destroy cells, cancer-initiating and clear viral infections. However, few reports describe natural product that stimulates cell IFN-γ production unravel mechanism action. In this study, through screening, we found product, phyllanthusmin C (PL-C), alone enhanced by human cells. PL-C also synergized IL-12, even at low cytokine concentration 0.1 ng/ml, stimulated...
Combinations of synthetic polymers and natural proteins provide a route to the synthesis new biomaterials. The bioconjugates combining tunable properties with functionalities have found broad applications. One most challenging problems in this research field is self-assembly behaviors responsive polymer–protein bioconjugates. In research, composed zwitterionic block copolymer streptavidin were investigated. Block copolymers poly(ethylene glycol) (PEG)...
Three series of new anthranilic diamide derivatives containing sulfide, N-cyanomethylsulfilimine, and N-cyanomethylsulfoximine groups were designed synthesized by coupling the active substructures diamides sulfoxaflor. The structures compounds confirmed infrared spectroscopy, 1H 13C NMR, elemental analysis. Several unique structural characteristics revealed via crystal structure analysis compound...
Methotrexate (MTX) is broadly applied in the clinic for treatment of cancers and autoimmune diseases. Targeted delivery MTX attractive to improve its efficacy reduce off-target toxicity. However, encapsulation nanoparticle challenging due high water solubility. We rationally designed a well-defined telodendrimer (TD) nanocarrier based on structure sequester it nanoparticles. Riboflavin (Rf) positive charge groups were precisely conjugated TD form multivalent hydrogen bonds, π–π stacking,...
Thermal-responsive polymer chains with pendant lysozyme molecules were prepared <italic>via</italic> a “grafting to” approach. The bioconjugates able to self-assemble into mesoglobules at temperature above their cloud point.
In these years, synthesis and self-assembly of nanoparticles with various sizes, geometries compositions have aroused great interest due to their scientific significance potential applications. The asymmetric structures are able self-assemble into hierarchical for constructing functional materials. To investigate the behaviors nano-sized polymer particles, twin single-chain (TSCNPs), a type covalently bonded SCNPs, reported in this research. A block copolymer pendant anthracene groups...
A facile and versatile method for the synthesis of Janus graphene oxide (GO) nanosheets with different structures is reported. Based on electrostatic assembly, GO can be easily functionalized a template polymer or defunctionalized by altering ionic strength. By using this approach, are prepared successfully hydrophobic polystyrene chains one side hydrophilic poly(2‐(dimethylamino)ethyl methacrylate) other side. image
Poly(2-hydroxyethyl methacrylate)–bovine serum albumin core–corona particles were prepared using<italic>in situ</italic>activators generated by electron transfer for atom radical polymerizations of HEMA initiated a BSA macroinitiator.
It is critical to regulate the senescence-associated secretory phenotype (SASP) due its effect on promoting malignant phenotypes and limiting efficiency of cancer therapy. In this study, we demonstrated that marchantin M (Mar-M, a naturally occurring bisbibenzyl) suppressed pro-inflammatory SASP components which were elevated in chemotherapy-resistant cells. Mar-M treatment attenuated pro-tumorigenic effects enhanced survival drug-resistant mouse models. No toxicity was detected normal...
Natural products and their derivatives have long been used as pharmacological agents in the fight against cancer. Human natural killer (NK) cells are critical our immune system that they capable of destroying tumor directly. However, there few reports elucidate role activating NK cells. In this study, we discovered a synthetic disaccharide derivative diphyllin, 4-O-{[2",3",4"-tri-O-acetyl-α-D-arabinopyranosyl-(1"→4')]-2',3'-di-O-acetyl-α-L-rhamnopyranosyl}diphyllin (TAARD), can alone...
Three series of new anthranilic diamide derivatives containing sulfide, N ‐cyanomethylsulfilimine, and ‐cyanomethylsulfoximine groups were designed synthesized by combining the active substructures diamides sulfoxaflor. The structures all newly compounds confirmed IR 1 H/ 13 C‐NMR, some them elemental analysis or HRMS too. screened for their insecticidal fungicidal activities. Bioasssay results indicated that possessed certain degrees activity against Mythimna separata . However, exhibited...
Serum protein adsorption on the nanoparticle surface determines biological identity of polymeric nanocarriers and critically impacts in vivo stability following intravenous injection. Ultrahydrophilic surfaces are desired delivery systems to reduce serum corona formation, prolong drug pharmacokinetics, improve performance nanotherapeutics. Zwitterionic polymers have been explored as alternative stealth materials for biomedical applications. In this study, we employed facial solid-phase...
Sepsis is a complex, life-threatening hyperinflammatory syndrome associated with organ failure and high mortality due to lack of effective treatment options. Here we report core-shell hydrogel nanoparticle the core functionalized telodendrimer (TD) nanotrap (NT) control hyperinflammation in sepsis. The combination multi-valent charged hydrophobic moieties TD enables binding biomolecules NT. higher crosslinking shell structure nanogel excludes abundant large serum proteins allows for...
Abstract Imbalanced immune regulation leads to the abnormal wound healing process, e.g., chronic unhealing or hypertrophic scar formation. Thus, attenuation of overflowing inflammatory factors is a viable approach maintain homeostatic facilitate normal healing. A versatile telodendrimer (TD) nanotrap (NT) platform developed for efficient biomolecular protein binding. The conjugation TD NT in size‐exclusive biocompatible hydrogel resin allows topical application cytokine scavenging....
ABSTRACT This research provides an efficient method for the fabrication of hybrid micelles with enzyme molecules at interfaces. Amphiphilic block copolymer is synthesized by reversible addition–fragmentation chain transfer (RAFT) polymerization, and thiol‐modified porcine pancreatic lipase (PPL‐SH) obtained treatment native PPL Traut's reagent. PPL‐SH conjugated to chains thiol‐disulfide exchange reaction. In phosphate buffered saline, bioconjugate self‐assembles into interfaces between...