A5102953705- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Acute Ischemic Stroke Management
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Lipoproteins and Cardiovascular Health
- Lung Cancer Diagnosis and Treatment
- Neuropeptides and Animal Physiology
- Cardiac Valve Diseases and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Hypoxia, and Metabolism
- Tracheal and airway disorders
- Medical Imaging Techniques and Applications
- Esophageal Cancer Research and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Ferroptosis and cancer prognosis
- Sepsis Diagnosis and Treatment
- RNA Research and Splicing
- Venous Thromboembolism Diagnosis and Management
- MRI in cancer diagnosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Aortic Disease and Treatment Approaches
- Neurological Disease Mechanisms and Treatments
- Neuroblastoma Research and Treatments
- Bone Metabolism and Diseases
Ningxia Medical University
2018-2025
Ningxia Medical University General Hospital
2025
Nanchang University
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Qilu Hospital of Shandong University
2017-2024
Ganzhou People's Hospital
2024
Southern Medical University
2024
Public Health Clinical Center of Chengdu
2019-2024
Second Affiliated Hospital of Nanchang University
2020-2024
Capital Medical University
2019-2023
Ferroptosis is increasingly becoming to be considered as an important mechanism of pathological cell death during stroke, and specific exogenous ferroptosis inhibitors have the ability reverse cerebral ischemia/reperfusion injury. However, research on Srs11-92 (AA9), a ferrostatin-1 (Fer-1) analog, in preclinical studies limited.In middle artery occlusion-reperfusion (MCAO/R) mice model or oxygen-glucose deprivation/reperfusion (OGD/R) model, Fer-1, AA9, and/or ML385 were administered, brain...
Hypoxia is a critical factor contributing to poor prognosis and challenging glioma therapy. Previous studies have indicated that hypoxia drives M2 polarization of macrophages promotes cancer progression in various solid tumors. However, the more complex diverse mechanisms underlying this process remain be elucidated. Here, we aimed examine functions gliomas preliminarily investigate macrophage caused by hypoxia. We found significantly enhances malignant phenotypes U87 U251 cells regulating...
ABSTRACT Background The mycobiome in the tumor microenvironment of non‐smokers with early‐stage lung adenocarcinoma (ES‐LUAD) has been minimally investigated. Methods In this study, we conducted ultra‐deep metagenomic and transcriptomic sequencing on 128 samples collected from 46 nonsmoking ES‐LUAD patients 41 healthy controls (HC), aiming to characterize tumor‐resident its interactions host. Results results revealed that exhibited fungal dysbiosis characterized by reduced species diversity...
This paper aimed to explore the roles of combination electroacupuncture (EA) and induced pluripotent stem cell-derived small extracellular vesicles (iPSC-EVs) on mice with ischemic stroke underlying mechanisms. A focal cerebral ischemia model was established in C57BL/6 through middle artery occlusion (MCAO). After 3 days, neurological impairment motor function were examined by performing behavioral tests. The infarct volume neuronal apoptosis using TTC staining TUNEL assays. Flow cytometry...
Carcinoma en cuirasse is mostly reported in breast cancer. It rarely originates from other visceral tumors such as lung In this report, we highlight the importance of skin biopsy not to make a misdiagnosis or missed diagnosis. We report 51-year-old male, diagnosed with adenocarcinoma 2 years ago, presenting swelling and hardening face neck. The patient was carcinoma cancer transferred oncology department for further management. Unfortunately, gave up treatment after 3 months died 1 year...
Abstract: Lumbar spinal stenosis (LSS) is a common disorder in the older population, and clinical syndrome consisting of pain buttock or lower extremity, with without low back corresponding imaging findings narrowing spaces around neural vascular elements lumbar spine. The diagnosis depends on history, symptoms, physical examination, radiographies. Varieties non-operative operative options are available for LSS patients. In this article, an update epidemiology, treatment was reviewed.
Gliomas are the most frequent primary malignant brain tumors of central nervous system, causing significant impairment and death. There is mounting evidence that N7 methylguanosine (m7G) RNA dysmethylation plays a role in development progression cancer. However, expression patterns function m7G methylation regulator gliomas yet unknown. The goal this study was to examine 31 critical regulators linked with their prognostic significance gliomas. To begin, we systematically analyzed patient...
This study was aimed to determine risk factors for the recurrence of an intracranial saccular aneurysm (ISA) following endovascular treatment. The findings will help medical professionals identify patients having a high ISA and assist them in developing appropriate follow-up plans.During period, 12.6% (83/658) experienced recurrent ISAs. An analysis related factors, including gender, age, hypertension, diabetes mellitus, smoking, tumor size, width neck, presence or absence rupture, volume...
Excessive absorption of osteoclasts will break the balance between and osteoblasts, leading to bone loss, decreased density, increased fragility. We have shown that Loureirin B (LrB) can inhibit osteoclasts. In this study, we demonstrated targeting-inhibitory mechanism LrB acting on osteoclast precursor. Using SPR, HPLC MALDI-TOF-MS capture analyze target protein in marrow macrophages (BMMs), used method detect all proteins acts BMMs, analyzed distribution enrichment rate by DAVID analysis....
Stroke is a type of acute brain damage that can lead to series serious public health challenges. Demonstrating the molecular mechanism stroke-related neural cell degeneration could help identify more efficient treatment for stroke patients. Further elucidation factors regulate microglia and nuclear factor (erythroid-derived 2)-like 1 (Nrf1) may promising strategy treating neuroinflammation after ischaemic stroke. In this study, we investigated possible role pterostilbene (PTS) in Nrf1...
Aim: To investigate the cost–effectiveness of afatinib and erlotinib as second-line therapy for advanced squamous cell carcinoma lung. Materials & methods: A decision-analytic model was developed projecting economic outcomes. Clinical parameters utilities were from LUX-Lung 8 trial. Costs mainly estimated Chinese health system. The outcome incremental ratio. Results: strategy generated additional 0.154 quality-adjusted life-years compared with erlotinib, costs ¥16,852. Relative to resulted...
Abstract Background: KOA, with a high incidence in old-age population, adversely affects their life quality. The valgus knee bracing is an important physical therapy for but its clinical effects on pain release and functional improvment are remained unclear. This meta-analysis to systematically evaluate the outcomes of patients osteoarthritis (KOA). Methods : A randomized controlled trials (RCTs) changes KOA after using braces. search period was ranged from inception database May, 2020....
Objectives Low-density lipoprotein cholesterol (LDL-C) plays an essential part in bone metabolism. However, the correlation between LDL-C levels and mineral density (BMD) is still controversial. This study aimed to explore relationship lumbar BMD young- middle-aged people. Methods We conducted a cross-sectional comprising 4,441 participants aged 20–59 from National Health Nutrition Examination Survey (NHANES). were used as independent dependent variables, respectively. evaluated through...
OBJECTIVE: To study the therapeutic value of cryosurgery with combination 125 iodine seed implantation for locally advanced pancreatic cancer. METHODS: Thirty‐eight patients cancer were enrolled in this study. The diagnosis was confirmed by pathology 31 patients. Ten had metastases peripancreatic lymph node and eight liver metastases. therapy included cryosurgery, which performed intra‐operatively or percutaneously under guidance ultrasound and/or computed tomography (CT), implantation,...
Apoptosis was demonstrated to be a major mode of intestinal epithelial cell death caused by ischemia/reperfusion ( II / R ). Ceramide has been proposed as messenger for apoptosis. The present study aimed investigate the effect Ginkgo biloba extract 761 (EGb 761) pretreatment on -induced mucosal apoptosis in rats and mechanism related ceramide. rat model injury produced clamping superior mesenteric artery 60 min followed reperfusion 180 min. Twenty four were randomly allocated into Sham, EGb...
Objective The objective of this study was to evaluate the 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) findings following complete radiofrequency ablation (RFA) treatment malignant lung tumors. Methods Follow-up PET and computed examinations in 18 patients (mean age, 67 ± 16 years [range, 30–91 years]; 10 males, 8 females) who underwent 19 RFA sessions for primary (n = 14) metastatic 5) tumors with mean follow-up months (range, 12–24 months) were retrospectively reviewed...
Follicular dendritic cell (FDC) sarcoma is a type of malignant tumor that originates from immune system-related FDCs. Pancreatic FDC rare disease, and the specificity clinical presentation laboratory results unknown. We report process imaging features one case pancreatic sarcoma. A 67-year-old woman presented with hypoechoic mass between spleen left kidney during medical examination. The patient was hospitalized for further diagnosis. Her did not present any obvious abnormal changes....
OBJECTIVE The aim of this study was to demonstrate the in vivo safety and antitumor effect a novel recombinant vesicular stomatitis virus (VSV): G protein less (GLESS)–fusion-associated small transmembrane (FAST)–VSV. METHODS Viral infection efficiency cell proliferation were detected using an inverted fluorescence microscope alarmaBlue assay, respectively. To evaluate virus, different doses GLESS-FAST-VSV positive control (VSV ∆M51 ) injected into normal F344 rats C57BL/6 mice, each...
We aimed to evaluate the predictors for early and interim culture conversion within 2 months 6 of treatment in multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) patients China.