A5103022612- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Asymmetric Synthesis and Catalysis
- Luminescence and Fluorescent Materials
- Cyclopropane Reaction Mechanisms
- Pancreatic function and diabetes
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Asymmetric Hydrogenation and Catalysis
- Catalytic C–H Functionalization Methods
- Fluorine in Organic Chemistry
- Oxidative Organic Chemistry Reactions
- Diabetes and associated disorders
- Epigenetics and DNA Methylation
- Molecular Sensors and Ion Detection
- Synthesis and Catalytic Reactions
- Adipose Tissue and Metabolism
- Diabetes Management and Research
- Nanoplatforms for cancer theranostics
- RNA Research and Splicing
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- Immune Cell Function and Interaction
Shihezi University
2021-2025
Kunming Institute of Zoology
2019-2024
Xinjiang Production and Construction Corps
2021-2024
University of Chinese Academy of Sciences
2014-2024
Chinese Academy of Sciences
2014-2023
University of Florida
2012-2023
First Hospital of Qinhuangdao
2023
Florida College
2004-2021
Green Chemistry
2021
South China University of Technology
2015-2020
The number and activity of brown adipocytes are linked to the ability mammals resist body fat accumulation. In some conditions, certain white adipose tissue (WAT) depots readily convertible a ‘‘brown-like’’ state, which is associated with weight loss. Irisin, newly identified hormone, secreted by skeletal muscles into circulation promotes WAT “browning” unknown mechanisms. current study, we demonstrated in mice that recombinant irisin decreased improved glucose homeostasis. We further showed...
Although organ-specific stem cells possess plasticity that permit differentiation along new lineages, production of endocrine pancreas and insulin-secreting beta from adult nonpancreatic has not been demonstrated. We present evidence highly purified rat hepatic oval "stem" cells, which are capable to hepatocytes bile duct epithelium, can trans-differentiate into pancreatic hormone-producing when cultured in a high-glucose environment. These differentiated self-assemble form three-dimensional...
Amines play vital roles in agricultural, pharmaceutical, and food industries, but volatile amine vapors are serious threats to human health. Previously reported fluorescent sensors for vapor detection usually suffer from aggregation-caused quenching (ACQ) effect need be dispersed solution or matrix materials. Herein, based on the fluorogen of 2-(2-hydroxyphenyl)quinazolin-4(3H)-one (HPQ) with aggregation-induced emission (AIE) properties, we have developed a sensor HPQ-Ac light-up through...
In this contribution, we propose natural resources as a new source to acquire biocompatible AIEgens.
Efficient synthesis of poly(enamine)s has been a great challenge because their poor stability, solubility, and low molecular weights. In this work, spontaneous amino-yne click polymerization for the efficient preparation was established, which could proceed with 100% atom efficiency under very mild conditions without any external catalyst. Through systematic optimization reaction conditions, several soluble thermally stable poly(β-aminoacrylate)s high weights (Mw up to 64400) well-defined...
Imaging the brain with high integrity is of great importance to neuroscience and related applications. X-ray computed tomography (CT) magnetic resonance imaging (MRI) are two clinically used modalities for deep-penetration imaging. However, their spatial resolution quite limited. Two-photon fluorescence microscopic (2PFM) its femtosecond (fs) excitation wavelength in traditional near-infrared (NIR) region (700-1000 nm) able realize deep-tissue high-resolution it requires craniotomy cranial...
Photoactivatable probes for lipid droplets (LDs)-specific live-cell imaging are powerful tools investigating their biological functions through precise spatial and temporal control.
An easily accessible aggregation-induced emission (AIE) probe is developed for LD-specific imaging and dynamic movement tracking with advantages of NIR two-photon excited red fast cell permeability.
PIP–TPE’s fluorescence turns on blue due to the large viscosity of lysosomes which restricts intramolecular motions but it red-shifts in bulk.
Irisin is a newly discovered myokine that links exercise with metabolic homeostasis. It involved in modest weight loss and improves glucose intolerance. However, the direct effects mechanisms of irisin on vascular endothelial cells (ECs) are not fully understood. In current study, we demonstrated promoted Human Umbilical Vein Endothelial Cell (HUVEC) proliferation. was further this pro-proliferation effect mediated by irisin-induced activation extracellular signal–related kinase (ERK)...
Abstract Genome-wide association studies (GWASs) have identified over 180 independent schizophrenia risk loci. Nevertheless, how the variants in reported loci confer susceptibility remains largely unknown. Here we systematically investigate gene regulatory mechanisms underpinning through integrating data from functional genomics (including 30 ChIP-Seq experiments) and position weight matrix (PWM). We identify 132 single nucleotide polymorphisms (SNPs) that disrupt transcription factor...
Abstract Red/near‐infrared dyes are highly demanded for biological applications but most of them far from satisfactory. In this work, a series red/near‐infrared fluorophores based on electron‐withdrawing benzo[1,2‐ b :4,5‐ ′]dithiophene 1,1,5,5‐tetraoxide (BDTO) synthesized and characterized. They possess both aggregation‐induced emission, hybridized local charge‐transfer characteristics. Crystallographic, spectroscopic, electrochemical computational results reveal that the oxidation to BDTO...
Silyl enol ethers react with bicyclo[1.1.0]butanes (BCBs) through Yb(OTf)
Procollagen N-proteinase (EC 3.4.24.14 ) cleaves the amino-propeptides in processing of type I and II procollagens to collagens. Deficiencies enzyme cause dermatosparaxis cattle sheep, they VIIC Ehlers–Danlos syndrome humans, heritable disorders characterized by accumulation pNcollagen severe skin fragility. Amino acid sequences for were used obtain cDNAs from bovine skin. Three overlapping had an ORF coding a protein 1205 residues. Mammalian cells stably transfected with complete cDNA...
Multidrug resistant bacterial infection has become one of the most serious threats to human health. Antimicrobial peptides (AMPs) have been identified as potential alternatives antibiotics owing their excellent bactericidal activity. However, complicated mechanism AMPs is still poorly understood. Fluorescence imaging many advantages in terms dynamic monitoring, easy operation, and high sensitivity. In this study, we developed an aggregation-induced emission (AIE)-active probe AMP-2HBT by...
To improve the treatment efficiency and reduce side effects in cancer therapy, accurate diagnosis of cell types at a molecular level is highly desirable. Fluorescent nanoparticles (NPs) are especially suitable for detecting biomarkers with advantages superior brightness, easy decoration high resolution. However, conventional organic fluorophores, conjugated polymers, inorganic quantum dots suffer from drawbacks aggregation-caused quenching (ACQ), low photostability, heavy metal toxicity,...
A newly prepared chiral-at-metal Rh(III) complex-catalyzed, highly efficient enantioselective decarboxylative Michael addition of β-keto acids with α,β-unsaturated 2-acyl imidazoles or pyridine has been developed, affording the corresponding adducts in 94–98% yield up to 96% enantioselectivity. This protocol exhibits remarkable reactivity, as complex a loading low 0.05 mol % can catalyze on gram scale without loss
A novel type of highly efficient chiral C2-symmetric bipyridine-N,N′-dioxides ligand application in catalyzing Michael addition/Cyclization 5-aminopyrazoles with α,β-unsaturated 2-acyl imidazoles has been developed, affording the corresponding adducts 85–97% yield up to 99% enantioselectivity under mild conditions a lower catalyst loading and broad scope. Remarkably, this protocol exhibits advantages terms reactivity enantioselectivity, giving fact that as low 2.2 mol % L1 2.0 Ni(OTf)2 can...
Pdx1 has been shown to convert hepatocytes into both exocrine and endocrine pancreatic cells in mice, but it fails selectively pure insulin-producing (IPCs). The molecular mechanisms underlying the transdifferentiation remain unclear. In this study, we generated a stably transfected rat hepatic cell line named WB-1 that expresses an active form of along with reporter gene, RIP-eGFP. Our results demonstrate induces expression multiple genes related pancreas development islet function these...
Abstract Two redox‐active porous organic frameworks (POFs) with a built‐in radical moiety (TEMPO) and hierarchical structures were synthesized through facile bottom‐up strategy studied as cathode materials for lithium–sulfur (Li−S) batteries. The sulfur loading in these two POFs reached 61 %, benefitting from their large pore volumes. Owing to the highly dense docking sites of TEMPO, could be covalently immobilized within networks efficiently inhibit shuttle effect, thereby significantly...
Photoactivatable fluorescent probes are ideal tools for organelle study with a significant advantage of high spatiotemporal resolution.
Optical cross-reactive sensor arrays have recently been proven to be a powerful tool for high-throughput bioanalytes identification. Nevertheless, identification and classification of microbes, especially using microbial lysates as the analytes, still is great challenge due their complex composition. Herein, we achieve this goal by luminogens featuring aggregation-induced emission characteristics (AIEgens) graphene oxide (GO) construct lysate responsive fluorescent array. The combination...