A5087201019- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Molecular Sensors and Ion Detection
- Nanocluster Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Photodynamic Therapy Research Studies
- Carbon and Quantum Dots Applications
- Porphyrin and Phthalocyanine Chemistry
- Organic Light-Emitting Diodes Research
- Microfluidic and Bio-sensing Technologies
- Geriatric Care and Nursing Homes
- 3D Printing in Biomedical Research
- Polydiacetylene-based materials and applications
- RNA modifications and cancer
- Biosimilars and Bioanalytical Methods
- Click Chemistry and Applications
- Legal principles and applications
- Cellular Mechanics and Interactions
- Cancer survivorship and care
- Polymer crystallization and properties
- Frailty in Older Adults
- Advanced Fluorescence Microscopy Techniques
- Mass Spectrometry Techniques and Applications
First Affiliated Hospital of Zhengzhou University
2018-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Henan Forestry Vocational College
2023
Vision Technology (United States)
2023
Nanjing Drum Tower Hospital
2019-2022
Zhengzhou University
2018-2021
University of Hong Kong
2016-2019
Hong Kong University of Science and Technology
2016-2019
Sun Yat-sen University Cancer Center
2016-2019
Sun Yat-sen University
2012-2019
The first water-soluble NIR AIEgen was synthesized and used for ultrafast wash-free cellular imaging photodynamic cancer cell ablation.
Fluorescence-imaging-guided photodynamic therapy has emerged as a promising protocol for cancer theranostics. However, facile preparation of such theranostic material simultaneously achieving bright emission with long wavelength, high-performance reactive oxygen species (ROS) generation, and good targeting-specificity cells, is highly desirable but remains challenging. In this study, novel type far-red/near-infrared-emissive fluorescent molecules aggregation-induced (AIE) characteristics...
In this contribution, we propose natural resources as a new source to acquire biocompatible AIEgens.
Abstract Red/near‐infrared (NIR) fluorescent molecules with aggregation‐induced emission (AIE) characteristics are of great interest in bioimaging and therapeutic applications. However, their complicated synthetic approaches remain the major barrier to implementing these Herein, a one‐pot strategy prepare series red/NIR‐emissive AIE luminogens (AIEgens) by fine‐tuning molecular structures substituents is reported. The obtained AIEgens possess simple structures, good solubilities, large...
Abstract Background The extracellular matrix (ECM) is essential for malignant tumour progression, as it a physical barrier to various kinds of anticancer therapies. Matrix metalloproteinase (MMPs) can degrade almost all ECM components, and macrophages are an important source MMPs. Studies using treat tumours have shown that enter tissue play regulatory role. Methods We modified with designed chimeric antigen receptor (CAR), which could be activated after recognition the HER2 trigger internal...
Cancer is the leading cause of death worldwide. With advantages low cost, high sensitivity and ease accessibility, fluorescence imaging has been widely used for cancer detection in scientific field. Aggregation-induced emission luminogens (AIEgens) are a class synthesized fluorescent probes with brightness photostability aggregate state. Herein, new positively-charged AIEgen, abbreviated as TPE-IQ-2O, designed characterized. TPE-IQ-2O not only can distinguish cells from normal contrast aid...
Efficient synthesis of poly(enamine)s has been a great challenge because their poor stability, solubility, and low molecular weights. In this work, spontaneous amino-yne click polymerization for the efficient preparation was established, which could proceed with 100% atom efficiency under very mild conditions without any external catalyst. Through systematic optimization reaction conditions, several soluble thermally stable poly(β-aminoacrylate)s high weights (Mw up to 64400) well-defined...
Non-aromatic peptides fluoresce under pressure.
A pair of propeller-like chiral trinuclear CuI clusters (R/S-Cu3) with unique photoinduced fluorescence enhancement were prepared. R/S-Cu3 showed intense variable luminescence after UV light irradiation, which was attributed to the stepwise oxidation ligand in clusters. It exhibited typical aggregation-induced emission (AIE) (αAIE =17.3). Mechanism studies that metal cluster-centered (MCC) and triplet metal-to-ligand charge-transfer (3 MLCT) processes are origin luminescence; regulated by a...
We retrospectively assessed the age- and sex-specific incidence relative risk of Parkinson disease (PD) in Taiwan's diabetic population.Study cohort included 603,416 patients 472,188 nondiabetic control subjects. Incidence rate PD (ICD-9-CM 332.0) were evaluated.The was 3.59 2.15 per 10,000 person-years for group, respectively, representing a covariate adjusted hazard ratio (HR) 1.61 (95% CI 1.56-1.66), which substantially reduced to 1.37 (1.32-1.41) after adjusting medical visits. Diabetes...
Abstract: N-rich metal-free and metal-doped carbon quantum dots (CQDs) have been prepared through one-step hydrothermal method using tetraphenylporphyrin or its transition metal (Pd Pt) complex as precursor. The structures morphology of the as-prepared nanoparticles were analyzed by X-ray diffraction, high-resolution transmission electron microscopy, photoelectron spectroscopy, Fourier transform infrared spectra. Three kinds nanocomposites show similar except for presence ions in Pd-CQDs...
Photoactivatable probes for lipid droplets (LDs)-specific live-cell imaging are powerful tools investigating their biological functions through precise spatial and temporal control.
An easily accessible aggregation-induced emission (AIE) probe is developed for LD-specific imaging and dynamic movement tracking with advantages of NIR two-photon excited red fast cell permeability.
PIP–TPE’s fluorescence turns on blue due to the large viscosity of lysosomes which restricts intramolecular motions but it red-shifts in bulk.
Abstract Visualization of the brain in its native environment is important for understanding common diseases. Herein, bright luminogens with remarkable aggregation‐induced emission (AIE) characteristics and high quantum yields up to 42.6% solid state are synthesized through facile reaction routes. The molecule, namely BTF, shows ultrabright far‐red/near‐infrared can be fabricated into AIE dots by a simple nanoprecipitation procedure. Due their brightness, large Stokes shift, good...
Abstract Aggregation‐induced emission (AIE) luminogens (AIEgens) with red/near‐infrared (NIR) emissions are appealing for applications in optoelectronics and biomedical engineering owing to their intrinsic advantages of efficient solid‐state emission, low background, deep tissue penetration. In this context, an AIEgen long‐wavelength is synthesized by introducing tetraphenylethene (TPE) the periphery electron‐deficient spiro ‐benzo[ d ]imidazole‐2,1′‐cyclohexane (BI). The resulting AIEgen,...
The incorporation of intensive light absorbing porphyrins macrocycles with biocompatible nanoparticles would lead to new nanomaterials multiple imaging and therapeutic modalities. Herein, a facile synthetic strategy has been applied prepare porphyrin-implanted carbon nanodots (PNDs) by partial selective pyrolysis 5,10,15,20-tetrakis(4-aminophenyl)porphyrin (TAPP) citric acid (CA) at an appropriate temperature. As-prepared PNDs exhibit not only the excellent stability biocompatibility...
Facile preparation of lanthanide hybridized carbon quantum dots (Ln-CQDs) and their potential for visible/NIR bioimaging<italic>in vivo</italic>.
New luminogens with aggregation-induced emission and delayed fluorescence features show good performance in lifetime imaging of living cells.
Silver staining, which exploits the special bioaffinity and chromogenic reduction of silver ions, is an indispensable visualization method in biology. It a most popular for in-gel protein detection. However, it limited by run-to-run variability, background inability quantification, compatibility with mass spectroscopic (MS) analysis; limitations that are largely attributed to tricky visualization. Herein, we reported novel water-soluble fluorogenic Ag+ probe, sensing mechanism based on...
An organic small molecule <bold>T-BDP</bold> with D–A–D structure was designed and synthesized could self-assemble into nanoparticles significant AIE performance. Under 635 nm laser irradiation, <bold>T-BDP NPs</bold> ablate cancer cells through photodynamic/photothermal synergistic effects.
Purpose . To investigate sleep quality of hospital staff nurses, both by subjective questionnaire and objective measures. Methods Female nurses at a regional teaching in Northern Taiwan were recruited. The Chinese version the pittsburgh index (C-PSQI) was used to assess quality, an electrocardiogram-based cardiopulmonary coupling (CPC) technique analyze stability. Work stress assessed using on medical worker’s stress. Results A total 156 completed study. Among 75.8% (117) had PSQI score ≥5...
The detection of food spoilage is a major concern in safety as large amounts are transported globally. Direct analysis samples often time-consuming and requires expensive analytical instrumentation. A much simpler more cost-effective method for monitoring fermentation to detect biogenic amines generated by-product during decomposition. In this work, series 1,2-dihydroquinoxaline derivatives (DQs) with aggregation-induced emission (AIE) characteristics were synthesised their protonated forms,...
An antibody-AIEgen conjugate is designed and developed as a "turn-on" fluorescent probe for wash-free specific cancer cell imaging. The cetuximab-conjugated AIEgen shows red fluorescence only when it internalized accumulated in cells with overexpressed epidermal growth factor receptor through endocytosis. first lights up the lysosomes. After hydrolysis, its residue mitochondria, making them highly emissive long retention time. Compared conventional "always-on" probes, exhibits very good...