A5101611815- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Cell death mechanisms and regulation
- Lipid metabolism and disorders
- Lymphoma Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- Arsenic contamination and mitigation
- Single-cell and spatial transcriptomics
- PI3K/AKT/mTOR signaling in cancer
- Angiogenesis and VEGF in Cancer
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Chronic Lymphocytic Leukemia Research
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Chemical Synthesis and Characterization
- Genetic factors in colorectal cancer
- ATP Synthase and ATPases Research
- Cancer Mechanisms and Therapy
- Chemokine receptors and signaling
- Protein Degradation and Inhibitors
- Metal-Organic Frameworks: Synthesis and Applications
Kunming University of Science and Technology
2024
Harbin Medical University
2024
Sun Yat-sen University Cancer Center
2015-2021
Sun Yat-sen University
2008-2021
State Key Laboratory of Oncology in South China
2013-2021
Methodist Hospital
2018-2019
Shenzhen University Health Science Center
2015-2018
Shenzhen University
2016
Key Laboratory of Guangdong Province
2013
Prodigiosin, a natural red pigment produced by numerous bacterial species, has exhibited promising anticancer activity; however, the molecular mechanisms of action prodigiosin on malignant cells remain unclear. Aberrant activation Wnt/β-catenin signaling cascade is associated with human cancers. In this study, we identified as potent inhibitor pathway. Prodigiosin blocked targeting multiple sites pathway, including low-density lipoprotein-receptor-related protein (LRP) 6, Dishevelled (DVL),...
The incorporation of intensive light absorbing porphyrins macrocycles with biocompatible nanoparticles would lead to new nanomaterials multiple imaging and therapeutic modalities. Herein, a facile synthetic strategy has been applied prepare porphyrin-implanted carbon nanodots (PNDs) by partial selective pyrolysis 5,10,15,20-tetrakis(4-aminophenyl)porphyrin (TAPP) citric acid (CA) at an appropriate temperature. As-prepared PNDs exhibit not only the excellent stability biocompatibility...
It is expected that prolonged circulation of anticancer drugs will increase their activity while decreasing toxic side effects. The purpose this study was to prepare 5-fluorouracil (5-FU) loaded block copolymers, with poly(γ-benzyl-L-glutamate) (PBLG) as the hydrophobic and poly(ethylene glycol) (PEG) hydrophilic block, then examine 5-FU release characteristics, pharmacokinetics, effects novel compound. PEG-PBLG (5-FU/PEG-PBLG) nanoparticles were prepared by dialysis scanning electron...
Natural killer (NK) cells are a key component of the innate immune system as they can attack cancer without prior sensitization. However, due to lack cell-specific receptors, NK not innately able perform targeted immunotherapy. Aptamers short single-stranded oligonucleotides that specifically recognize their targets with high affinity in similar manner antibodies. To render target-specificity, synthetic CD30-specific aptamers anchored on cell surfaces produce aptamer-engineered (ApEn-NK)...
Topoisomerase II alpha (TOP2A) protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. The prognostic effect of TOP2A seems different among subtypes breast cancer. current study evaluated the impact on luminal Altogether 434 stage I-II cancer patients who underwent curative surgery in Sun Yat-Sen University Cancer Center between 2007 2009 were enrolled. expression was assessed by immunohistochemistry. Clinical pathological data retrospectively...
A randomized, open-label, phase 2, multicenter clinical trial was conducted to evaluate the efficacy and safety of addition a recombinant human endostatin adenovirus (E10A) cisplatin paclitaxel in patients with advanced head neck squamous cell carcinoma or nasopharyngeal carcinoma. Patients locally metastatic not suitable for operation radiotherapy were randomly assigned receive E10A plus chemotherapy every 3 weeks maximum six cycles only. One hundred thirty-six eligible assigned. The did...
Hepatocellular carcinoma (HCC) is a hypervascular cancer without effective treatment. Here we report that polypeptide of NC1 domain type VIII collagen (Vastatin) an endogenous expressed in normal liver tissue but lost the most HCC patients (73.1%). Its expression level negatively associated with tumor size (P = 0.035) and metastasis 0.016) patients. To evaluate its potential use as therapeutic, constructed recombinant adeno-associated virus carrying Vastatin (rAAV-Vastatin) to treat...
Background: Malignant lymphomas are a group of distinct lymphoid neoplasms, exhibiting marked diversity in biological behaviors and clinical outcomes.Liquid biopsy, such as circulating cell-free DNA (cfDNA), has recently been attempted to be used for mutation profiling using next-generation sequencing (NGS).However, only limited data about cfDNA restricted Hodgkin's lymphoma B cell lymphoma, there is no report the T so far.Patient Methods: Medical records total 50 patients were...
Breast cancer remains a leading cause of mortality in women worldwide. Triple-negative breast (TNBC) is particularly aggressive subtype characterized by rapid progression, poor prognosis, and lack clear therapeutic targets. In the clinic, delineation tumor heterogeneity development effective drugs continue to pose considerable challenges. Within scope our study, high inherent was uncovered based on landscape constructed from both healthy tissue samples. Notably, TNBC exhibited significant...
BackgroundBlood-based biomarker such as circulating tumor DNA (ctDNA) has emerged a promising tool for assessment of response to immunotherapy in solid tumors; But hematological malignances, evidences are still lacking support its clinical utility. In current study the feasibility ctDNA prediction and monitoring anti-PD-1 therapy Chinese patients with relapsed or refractory classical Hodgkin lymphoma (r/r cHL) was assessed.MethodsA total 192 plasma samples from 75 r/r cHL were collected at...
The mixed-metal organic framework La/Zr-MOF-4 exhibits both La-BDC and Zr-BDC morphology characteristics with a maximum adsorption capacity of 694 mg g −1 for arsenic, making it promising candidate material wastewater treatment.
Abstract Background Triple-negative breast cancer (TNBC) patients have relatively poor clinical outcomes. A marker predicting the prognosis of with TNBC could help guide treatment. Extensive evidence demonstrates that angiopoietin-like 4 (ANGPTL4) is involved in regulation growth, metastasis and angiogenesis. Therefore, its role interest. Methods: We tested ANGPTL4 expression level tumor tissues by immunohistochemistry (IHC) detected association features patients. Next, effects mechanisms on...
PurposeThe purpose of the current study were to assess safety and feasibility repetitive intratumoral administration E10A, an adenoviral vector encoding wild-type endostatin gene, patients with solid tumors, evaluate its biologic effect pharmacokinetics endostatin.MethodsPatients treated escalating doses from 1×1010 VP 1×1012 E10A intratumorally on days 1 8. Patients assessed for toxicity viral shedding, antitumor response was evaluated by imaging techniques tumor biopsy. Circulating levels...
Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase and key element in the phosphatidylinositol 3-kinase (PI3K)/protein B (Akt) signaling pathway. Moreover, it negative regulator autophagy acts as central cell growth. For treatment cancer, mTOR novel validated therapeutic target. Previous studies have shown that Akt frequently activated nasopharyngeal carcinoma (NPC) tissues; thus, inhibition may be strategy for this tumor type. To evaluate effect inhibitor RAD001 on...
Gene expression in metazoans is delicately organized. As genetic information transmits from DNA to RNA and protein, noise inevitably generated. Recent studies begin unveil the mechanisms of gene control, but changes precision pathologic conditions like cancers are unknown. Here we analyzed transcriptomic data human breast, liver, lung colon cancers, found that more than 74.9% genes was increased cancer tissues as compared adjacent normal tissues. This suggested controlling collapsed during...
6-Phosphofructo-2-kinase/fructose-2,6-biphosphate-4 (PFKFB4) is a key factor that plays an important role in tumorigenesis. However, its triple-negative breast cancer (TNBC) progression needs to be further validated. We investigated whether PFKFB4 directly involved the oncogenic signaling networks of TNBC. First, we assessed expression level tumor tissue specimens by immunohistochemistry and evaluated prognostic value. Next, effect on TNBC cell growth associated mechanisms were investigated....
Cyclin‑dependent kinase inhibitor 2A (p16INK4a) protein is a surrogate immunohistochemical marker of human papillomavirus infection in oropharynx squamous cell carcinoma (OPSCC). However, the effects p16INK4a non‑OPSCC require additional analysis. In addition, major gaps remain literature, including small volumes data for China. Therefore, present study evaluated frequency positivity patients with Southern China, and assessed its prognostic value. expression status was determined by...
Abstract Background: Triple-negative breast cancer (TNBC) patients have relatively poor clinical outcomes. A marker predicting the prognosis of with TNBC could help guide treatment. Extensive evidence demonstrates that angiopoietin-like 4 (ANGPTL4) is involved in regulation growth, metastasis and angiogenesis. Therefore, its role interest.Methods: We tested ANGPTL4 expression level tumor tissues by immunohistochemistry (IHC) detected association features patients. Next, effects mechanisms on...
Abstract Deubiquitinase BRISC complex plays important role in the maintenance of spindle structure and function; however, underlying mechanism remains largely undefined. Here we demonstrated that MERIT40, a core component complex, directly interacts with RXXPEG motif ARC‐V domain Tankyrase1(TNKS1). Mutation MERIT40 (R28A) disrupted its interaction TNKS1. Consistent these data, R28A mutant cells displayed multiple mitotic defects including aberrant assembly chromosome misalignment. These...