A5080482277- Rough Sets and Fuzzy Logic
- Advanced Computational Techniques and Applications
- Data Mining Algorithms and Applications
- Seed Germination and Physiology
- Polysaccharides and Plant Cell Walls
- Advanced biosensing and bioanalysis techniques
- Plant tissue culture and regeneration
- Phytochemistry and Biological Activities
- Polysaccharides Composition and Applications
- RNA Interference and Gene Delivery
- Biochemical and Molecular Research
- Semantic Web and Ontologies
- Advanced Algebra and Logic
- Plant Molecular Biology Research
- Multi-Criteria Decision Making
- Natural Language Processing Techniques
- Reliability and Maintenance Optimization
- HIV/AIDS drug development and treatment
- Cancer therapeutics and mechanisms
- Text and Document Classification Technologies
- Data Management and Algorithms
- Software Reliability and Analysis Research
- Advanced Chemical Physics Studies
- Autophagy in Disease and Therapy
- Natural product bioactivities and synthesis
Xidian University
2014-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2025
Dalian University of Technology
2021-2025
First Affiliated Hospital of Wannan Medical College
2023-2024
Beijing Municipal Engineering Design and Research Institute (China)
2017-2024
Dalian Institute of Chemical Physics
2024
Chinese Academy of Sciences
2024
Wannan Medical College
2023
North China Electric Power University
2022-2023
HBIS (China)
2022-2023
Dihydropteroate synthase (DHPS) is the target of sulfonamide class antibiotics and has been a validated antibacterial drug for nearly 70 years. The sulfonamides p-aminobenzoic acid (pABA) binding site DHPS interfere with folate biosynthesis ultimately prevent bacterial replication. However, widespread resistance to these drugs severely limited their effectiveness. This study explores second more highly conserved pterin as an alternative approach developing novel that avoid resistance. In...
The receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 spike (S) protein plays a central role in mediating first step virus infection to cause disease: binding angiotensin-converting enzyme (ACE2) receptors on human host cells. Therefore, S/RBD is an ideal target for blocking and neutralization therapies prevent treat disease 2019 (COVID-19). Using target-based selection approach, we developed oligonucleotide aptamers containing conserved sequence motif that...
Background: Caloric restriction mimetics (CRMs) mimic the favourable effects of caloric (CR) and have been shown to therapeutic in neuroinflammatory disease. However, whether CRMs improve functional recovery from spinal cord injury (SCI) underlying mechanism action remain unclear. In this study, we used 3,4-dimethoxychalcone (3,4-DC) evaluate value for SCI. Methods: HE, Masson Nissl staining; footprint analysis; Basso mouse scale were determine SCI after 3,4-DC treatment. RNA sequencing was...
Necroptosis and pyroptosis, two types of proinflammatory programmed cell death, were recently found to play important roles in spinal cord injury (SCI). Moreover, cyclic helix B peptide (CHBP) was designed maintain erythropoietin (EPO) activity protect tissue against the adverse effects EPO. However, protective mechanism CHBP following SCI is still unknown. This research explored necroptosis- pyroptosis-related underlying neuroprotective effect after SCI. Gene Expression Omnibus (GEO)...
Abstract Preventing and treating avascular necrosis at the distal end of flaps are critical to surgery success, but current treatments not ideal. A recent study shows that apoptotic bodies (ABs) generated near site apoptosis can be taken up promote cell proliferation. The reveals ABs derived from fibroblast‐like cells in subcutaneous connective tissue (FSCT cells) skin promoted ischaemic flap survival. It is also found inhibited death oxidative stress M1‐to‐M2 polarization macrophages....
Nitrofuranylamides (NFAs) are nitroaromatic compounds that have recently been discovered and potent anti-tuberculosis (TB) activity. A foundational study was performed to evaluate whether this class of agents possesses microbiological properties suitable for future antimycobacterial therapy.Five representative the NFA series were evaluated by standard assays determine MICs, MBCs, activity against anaerobic non-replicating persistent Mycobacterium tuberculosis, post-antibiotic effects (PAEs),...
Natural killer (NK) cells are a key component of the innate immune system as they can attack cancer without prior sensitization. However, due to lack cell-specific receptors, NK not innately able perform targeted immunotherapy. Aptamers short single-stranded oligonucleotides that specifically recognize their targets with high affinity in similar manner antibodies. To render target-specificity, synthetic CD30-specific aptamers anchored on cell surfaces produce aptamer-engineered (ApEn-NK)...
Dihydropteroate synthase (DHPS) is a key enzyme in bacterial folate synthesis and the target of sulfonamide class antibacterials. Resistance toxicities associated with sulfonamides have led to decrease their clinical use. Compounds that bind pterin binding site DHPS, as opposed p-amino benzoic acid (pABA) targeted by agents, are anticipated bypass resistance. To identify such inhibitors map pocket, we performed virtual screening, synthetic, structural studies using Bacillus anthracis DHPS....
Abstract Ciclopirox (CPX) modulates multiple cellular pathways involved in the growth of a variety tumor cell types. However, effects CPX on colorectal cancer (CRC) and underlying mechanisms for its antitumor activity remain unclear. Herein, we report that exhibited strong antitumorigenic properties CRC by inducing cycle arrest, repressing migration, invasion affecting N-cadherin, Snail, E-cadherin, MMP-2, MMP-9 expression, disruption bioenergetics contributed to CPX-associated inhibition...
Necrosis of random-pattern skin flaps limits their clinical application. Helix B surface peptide (HBSP) protects tissues from ischaemia-reperfusion injury but its short plasma half-life applications. Here, we have synthesized cyclic helix (CHBP) and investigated role in flap survival the underlying mechanisms.Flap viability was evaluated by area analysis, laser Doppler blood flow histological analysis. RNA sequencing used to identify mechanisms effects CHBP. Levels autophagy, oxidative...