A5090510710- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Molecular Sensors and Ion Detection
- Computational Drug Discovery Methods
- Molecular spectroscopy and chirality
- Catalytic C–H Functionalization Methods
- Asymmetric Synthesis and Catalysis
- Analytical Chemistry and Chromatography
- Chemical Synthesis and Analysis
- Synthesis and Biological Evaluation
- Asymmetric Hydrogenation and Catalysis
- Amino Acid Enzymes and Metabolism
- Innovative Microfluidic and Catalytic Techniques Innovation
- Click Chemistry and Applications
- Cyclopropane Reaction Mechanisms
- Synthesis of Tetrazole Derivatives
- Synthesis and Catalytic Reactions
- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Synthetic Organic Chemistry Methods
- Sulfur-Based Synthesis Techniques
- Axial and Atropisomeric Chirality Synthesis
- Synthesis and Characterization of Heterocyclic Compounds
- HIV/AIDS Research and Interventions
Wuhan Institute of Technology
2015-2025
Huazhong University of Science and Technology
2024
Dalian University of Technology
2024
Instytut Farmaceutyczny
2023
Ministry of Education of the People's Republic of China
2020
University of Virginia
2015-2019
Jiangsu University of Technology
2018
Fudan University
2010-2012
Yale University
2005
Tsinghua University
1999-2003
A novel fluorescent probe based on a bisbinaphthyl structure has been designed and synthesized. This compound in combination with Zn(II) exhibited highly enantioselective fluorescence enhancement 13 common free amino acids. For example, its enantiomeric ratios (ef or ΔIL/ΔID) the presence of following acids are extremely high: 177 for valine, 199 methionine, 186 phenylalanine, 118 leucine, 89 alanine. The observed high enantioselectivity extent substrate scope unprecedented recognition can...
An organic small molecule <bold>T-BDP</bold> with D–A–D structure was designed and synthesized could self-assemble into nanoparticles significant AIE performance. Under 635 nm laser irradiation, <bold>T-BDP NPs</bold> ablate cancer cells through photodynamic/photothermal synergistic effects.
A novel method is described for the synthesis of 2,4-disubstituted oxazole and thiazole derivates via coupling α-diazoketones with (thio)amides or thioureas using trifluoromethanesulfonic acid (TfOH) as a catalyst. This protocol characterized by mild reaction conditions, metal-free, simplicity also features good functional group tolerance, to excellent yields, broad substrate scope more than 40 examples. Experimental studies suggest mechanism involving 2-oxo-2-phenylethyl...
Accurate estimation of aboveground biomass (AGB) in Moso bamboo forests (MBFs) has garnered significant attention over the past two decades. However, remote sensing-based AGB MBFs remains challenging because limited understanding relationship between growth characteristics and sensing data, particularly concerning alternating on-year off-year cycles. In this study, Sentinel-2 imagery plot survey data were selected, a novel change detection algorithm to assess level dynamics 2018 2019 was...
Chiral benzothiazepines constitute the core structures of many foremost pharmaceuticals with diverse biological activities endowed by their unique scaffolds, which poses a great challenge to organic chemists and pharmaceutical researchers. This review provides concise overview for asymmetric synthesis chiral benzothiazepine derivatives, focusing on advances in catalysis, including metal small-molecule organocatalysis enzymatic catalysis. The catalytic reactions, involving epoxidation,...
A series of novel diarylpyridine derivatives has recently been identified as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs), and most them exhibited potent activities against strains, with EC50 values in the low nanomolar range. However, three-dimensional quantitative structure-activity relationships (3D-QSARs) pharmacophore characteristics these compounds remain to be studied. In present study, forty-two were firstly docked into transcriptase, molecular dynamics (10 ns)...
The selective incorporation of phosphorus groups into sugar molecules holds substantial synthetic and biological significance, yet this area research remains largely unexplored. In study, we successfully devised a novel method employing an efficient Fe(III) catalyst for achieving site/regioselective phosphorylation/phosphinoylation carbohydrates. This methodology boasts several merits, including mild reaction conditions, the employment cost-effective readily available catalysts, exceptional...
Continuous flow chemistry, as an emerging technology and a significant trend in the field of pharmaceutical synthesis, has been increasingly employed both academic laboratories miniature industrial workshops to produce various compounds intermediates. Compared traditional batch production methods, this enhances heat mass transfer effects during reaction process, thereby reducing times yielding purer products with greater consistency quality. Furthermore, continuous enables precise control...
Naphthofuran skeletons serve as pivotal structural constituent in a plenty of bioactive molecules and luminescent materials. Herein, we present an unprecedented Zn-catalyzed aerobic oxidative ring-opening/[3+2] cyclization cascade cyclopropanols with...