A5070016350- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Molecular Sensors and Ion Detection
- Molecular spectroscopy and chirality
- Analytical Chemistry and Chromatography
- Amino Acid Enzymes and Metabolism
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Metabolomics and Mass Spectrometry Studies
- Phytochemicals and Antioxidant Activities
- Tea Polyphenols and Effects
- Axial and Atropisomeric Chirality Synthesis
- RNA Interference and Gene Delivery
- HIV/AIDS Research and Interventions
- Cancer Mechanisms and Therapy
- Cancer therapeutics and mechanisms
- Chromatography in Natural Products
- Sirtuins and Resveratrol in Medicine
- Neuroscience and Neuropharmacology Research
- Synthesis and biological activity
- Metal complexes synthesis and properties
- Natural product bioactivities and synthesis
- Synthesis and Characterization of Heterocyclic Compounds
Wuhan Institute of Technology
2014-2024
University of Virginia
2018-2019
Anhui University
2012
A novel fluorescent probe based on a bisbinaphthyl structure has been designed and synthesized. This compound in combination with Zn(II) exhibited highly enantioselective fluorescence enhancement 13 common free amino acids. For example, its enantiomeric ratios (ef or ΔIL/ΔID) the presence of following acids are extremely high: 177 for valine, 199 methionine, 186 phenylalanine, 118 leucine, 89 alanine. The observed high enantioselectivity extent substrate scope unprecedented recognition can...
A fluorophilic fluorescent probe based on a perfluoroalkyl-substituted bis(binaphthyl) compound was designed and synthesized. It displayed highly enantioselective fluorescence response toward structurally diverse amino acids in biphasic fluorous/aqueous system with enantiomeric enhancement ratio (ef; ΔID /ΔIL ) values up to 45.2 (histidine). can be used determine the compositions of also allows acid enantiomers visually discriminated. NMR mass-spectroscopic investigations provided insights...
Abstract:: β-Nicotinamide mononucleotide (β-NMN), a key precursor in the biosynthesis of nicotinamide adenine dinucleotide (NAD+) mammals, has significant effects replenishing NAD+ levels body, so it obvious ameliorative on metabolic and age-related degenerative diseases. β-NMN is widely used healthcare products, food, cosmetics. It considerable commercial worth promising medical application prospects. Hence, development methods for preparing great research significance. This review...
Abstract This review covers the recent development on natural occurrence, functional elucidations, and analysis of amino acids D (dextro) configuration. In pharmaceutical field, are not only used directly as clinical drugs nutriments, but also widely applied starting materials, catalysts, or chiral ligands for synthesis active ingredients. Earler belief hold that L-amino exist in nature D-amino were artificial products. However, increasing evidence indicates naturally occurring living...
a,c ( a 武汉工程大学化工与制药学院 绿色化工过程教育部重点实验室 武汉 430205