A5100426081- Cardiac Imaging and Diagnostics
- Photoacoustic and Ultrasonic Imaging
- Coronary Interventions and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiovascular Health and Disease Prevention
- Ultrasound Imaging and Elastography
- Cardiac Valve Diseases and Treatments
- Advanced MRI Techniques and Applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Advanced X-ray and CT Imaging
- Cerebrovascular and Carotid Artery Diseases
- Nanoplatforms for cancer theranostics
- Electrospun Nanofibers in Biomedical Applications
- Acute Myocardial Infarction Research
- Graphene and Nanomaterials Applications
- AI in cancer detection
- Tracheal and airway disorders
- Atrial Fibrillation Management and Outcomes
- Testicular diseases and treatments
- Extracellular vesicles in disease
- Optical Imaging and Spectroscopy Techniques
- Cardiovascular Disease and Adiposity
- Tissue Engineering and Regenerative Medicine
- Nanoparticles: synthesis and applications
- Wound Healing and Treatments
Harbin Institute of Technology
2024-2025
Qilu Hospital of Shandong University
2007-2024
Tobacco Research Institute
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
Shandong University
2008-2024
Chinese People's Liberation Army
2024
Chinese PLA General Hospital
2019-2024
State Key Laboratory for Innovation and Transformation of Luobing Theory
2024
Henan University of Science and Technology
2023
Xian Central Hospital
2023
Objective: This study is to evaluate the anti-obese effects of glucosamine (GLC) and chitosan oligosaccharide (COS) on high-fat diet-induced obese rats. Methods: The rats were randomly divided into twelve groups: a normal diet group (NF), (HF), Orlistat group, GLC high-, middle-, low-dose groups (GLC-H, GLC-M, GLC-L), COS1 (COS, number-average molecular weight ≤1000) (COS1-H, COS1-M, COS1-L), COS2 ≤3000) (COS2-H, COS2-M, COS2-L). All received oral treatment by gavage once daily for period...
Hydrogel products for chronic diabetic wounds, a serious and prevalent complication of diabetes, show limited effects on disability remain nonspecific. Thus, improvements in the usage pharmaceutical molecule hydrogels are highly desirable to increase therapeutic effect hydrogels. In this study, thioctic acid (a common medicine diabetes treatment) is used preparing regenerative antibacterial (RAH) which contains situ synthesized silver nanoparticles (AgNPs). The RAH shows regenerative,...
Abstract Bacterial infections account for countless deaths globally. Antibiotics are the primary countermeasure; however, alarming spread of antibiotic‐resistant strains necessitates alternative solutions. Silver and silver compounds have emerged as promising antibacterial agents. However, issues related to cytotoxicity genotoxicity remain concern. To overcome these challenges, this proposes an easy‐to‐control straightforward method synthesize novel Silver─gallium (Ag─Ga) nano‐amalgamated...
Abstract Nanotechnology employs multifunctional engineered materials in the nanoscale range that provides many opportunities for translational stem cell research and therapy. Here, a cell‐penetrating peptide (virus‐1 transactivator of transcription)–conjugated, porous silicon nanoparticle (TPSi NP) loaded with Wnt3a protein to increase both survival rate delivery precision transplantation via combinational theranostic strategy is presented. The TPSi NP pore size 10.7 nm inorganic framework...
Rupture or erosion of inflammatory atherosclerotic vulnerable plaque is essential to acute coronary events, while the target intervene very challenging, due relatively small volume, high hemodynamic shear stress, and multifactorial nature lesion foci. Herein, we utilize biological functionality neutrophil versatility microbubble in acoustic field, form Neu-balloon through CD11b antibody binding. The inherits advantage neutrophils on firming endothelium adhesion even at stress up 16 dyne/cm2...
Background: Since the poor response to existing anti-tuberculosis drugs and low drug concentration in local bone tissues, traditional therapy does not result satisfactory treatment of osteoarticular tuberculosis. Thus, we report a rifapentine release system with imparted targeting potential using tetracycline (TC) -modified nanoparticles (NPs). Methods: TC was conjugated PLGA-PEG copolymer via DCC/NHS technique. Rifapentine-loaded NPs were prepared by premix membrane emulsification The...
ABSTRACT The aim of this paper is to exploit a small sample (data scarcity) target segmentation technique for image‐guided radiation therapy. grounded on prototype‐based approach—widely used method. In paper, we propose foreground–background difference knowledge learning framework perform the task. Its main differences from traditional approaches and novel contributions may be enumerated in two aspects: (1) A subdivision strategy generate multiple prototypes each class support images,...
Background: Antibody-drug conjugates have recently been introduced as a treatment for advanced urothelial carcinoma. The EV-301 study demonstrated that enfortumab vedotin (EV) improved overall survival compared with conventional chemotherapy. To assess the cost-effectiveness of EV carcinoma (UC) from payer perspective in middle- and high-income countries. Methods: A decision analysis model was developed to efficacy economic viability subsequent-line following disease progression patients...
Segmentation of the left ventricular (LV) myocardium in 2-D echocardiography is essential for clinical decision making, especially geometry measurement and index computation. However, segmenting a time-consuming process challenging due to fuzzy boundary caused by low image quality. The ground-truth label employed as pixel-level class associations or shape regulation segmentation, which works limit effective feature enhancement echocardiography. We propose training strategy named...
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are major causes of failure, but currently, no effective pharmacotherapy exists for these disorders. Alveolar macrophages play a critical role in both the acute/initial phase chronic/resolving ALI, rendering them potential therapeutic target. Interleukin-4 (IL-4), Th2 cytokine, not only directly inhibits secretion pro-inflammatory factors from also drives to anti-inflammatory tissue remodeling M2 type. However, short...
Background . Currently, echocardiography has become an essential technology for the diagnosis of cardiovascular diseases. Accurate classification apical two-chamber (A2C), three-chamber (A3C), and four-chamber (A4C) views precise detection left ventricle can significantly reduce workload clinicians improve reproducibility segmentation. In addition, is significant three-dimensional reconstruction heart chambers. Method RetinaNet a one-stage object algorithm that achieve high accuracy...
Intravascular ultrasound (IVUS) can provide high-resolution cross-sectional images of coronary arteries, showing detailed information the vascular lumen, tube wall, and athermanous plaques, which is helpful for discovery or identification early atherosclerotic plaques. Multiple parameters extractable from IVUS image help cardiologist analyze pathology assist in disease diagnosis postoperative treatment. Typically, cardiologists manually label intima adventitia image, obtain a limited number...
Intervertebral disc degeneration (IVDD) is a predominant cause of herniation and widespread worldwide. Inflammatory responses, mitochondrial dysfunction, extracellular matrix degradation are known to be involved in IVDD. Scutellarin, an active ingredient extracted from Erigeron breviscapus (Vaniot) Ha, Hand-Mazz, reported exhibit therapeutic potential several degenerative diseases by suppressing inflammation regulating metabolism. However, whether scutellarin can improve IVDD remains...
Purpose We aimed to investigate the mortality patterns and quantitatively assess risks of cardiovascular death (CVD) in patients with colorectal cancer (CRC). also established a competing-risk model predict probability CVD for CRC. Patients Methods CRC who diagnosed between 2007 2015 Surveillance, Epidemiology, End Results (SEER) database were included present study. The cumulative incidence function (CIF) was used other causes death, Gray’s test determine subgroup difference CIF. Fine-Gray...
Intravascular photoacoustic (IVPA) imaging, benefiting from high optical contrast, large imaging depth and absorption specificity, is of great potential for lipid-rich plaque detection. However, the diameters reported IVPA endoscopes are too big to intervene into coronary artery branches. Here, by designing an ultracompact house embedded with a side-fire fiber miniature single-element ultrasound transducer, we developed ultrafine endoscope diameter 0.7 mm aiming at branches atherosclerotic...
The prevailing open-structure intravascular photoacoustic (IVPA) endoscope emits a gradually deformed laser beam with exposed optical or acoustical components bearing pollution and damage in arterial lumen. Deformed scanning, which causes low excitation efficiency serious deterioration of the transverse resolution, is current big obstacle to application endoscopy imaging. Hence, stable reliable IVPA indispensable. In this letter, we designed high-robustness (HR-IVPA) hermetically sealed...