A5100404332- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Diabetes Management and Research
- Diet, Metabolism, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Alcohol Consumption and Health Effects
- Thyroid Disorders and Treatments
- Liver Diseases and Immunity
- Pneumocystis jirovecii pneumonia detection and treatment
- Forensic Anthropology and Bioarchaeology Studies
- Cancer, Hypoxia, and Metabolism
- Pharmaceutical studies and practices
- Liver physiology and pathology
- Pancreatic function and diabetes
- Pharmacological Effects of Natural Compounds
- Connective tissue disorders research
- Pregnancy-related medical research
- Dental Health and Care Utilization
- IPv6, Mobility, Handover, Networks, Security
- Cancer, Lipids, and Metabolism
- Dietary Effects on Health
- Natural Antidiabetic Agents Studies
- Maternal and Perinatal Health Interventions
- Drug-Induced Hepatotoxicity and Protection
Huizhou Central People's Hospital
2021-2025
Bioengineering Center
2024
Dalian Institute of Chemical Physics
2024
Dalian University of Technology
2024
Chinese Institute for Brain Research
2024
Shenyang Pharmaceutical University
2024
King University
2024
Peking University
2024
University of California, Berkeley
2024
Bioscience (China)
2024
Abstract We explored the role of micro RNA ‐30a (miR‐30a) and mechanism involved in hepatic fibrosis. MiR‐30a overexpression was achieved by miR‐30a mimics transfection stellate cells ( HSC s) ‐T6, LX ‐2), agomir (ago‐miR‐30a) treatment mice. levels were measured using TaqMan mi assay system, localization detected fluorescence situ hybridization FISH ). The interaction Beclin1 confirmed dual‐luciferase reporter assay. Autophagic flux analysed tandem mRFP ‐ GFP LC 3 microscopy, electron...
Both low-carbohydrate (LC) and calorie-restricted (CR) diets have been shown to metabolic benefits. However, the two regimens yet be thoroughly compared. We conducted a 12-week randomized trial compare effects of these separately in combination on both weight loss risk factors overweight/obese individuals.
Abstract Context Thyroid function variation within the thyroxine reference range has negative metabolic effects. Metabolic dysfunction-associated fatty liver disease (MAFLD) is a recently proposed definition. Objective We aim to explore effects of thyroid status on prevalence and mortality MAFLD. Methods Data 10 666 participants from Third National Health Nutrition Examination Survey (NHANES III) were used. MAFLD was diagnosed based new defined thyroid-stimulating hormone (TSH) levels:...
Few of the available therapies for type 2 diabetes (T2D) comprehensively address disease burden beyond glycemic control. Examining whether berberine ursodeoxycholate (HTD1801), a first-in-class gut-liver anti-inflammatory metabolic modulator, has potential to treat core aspects is important. To assess safety and efficacy HTD1801 in patients with T2D that inadequately controlled diet exercise. This phase double-blind, placebo-controlled, 12-week randomized clinical trial, conducted China...
Background/Aims: Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease. However, no effective treatments for this are available. Calcium dobesilate (CaD) widely used to treat diabetic retinopathy. DKD and retinopathy often co-exist have similar mechanisms pathogenesis. The aim the present study was elucidate safety efficacy CaD in treatment DKD. Methods: In prospective randomised controlled study, 100 from Type 2 diabetes mellitus (DM) patients with urinary albumin/...
Abstract Background Obesity and dental caries among children adolescents are growing worldwide public health problems. They share some common modifiable influences. The objective of this study was to evaluate the prevalence obesity in Huizhou explore association between Body Mass Index (BMI) category caries. Methods This cross-sectional enrolled 105,181 students (55,500 males 49,681 females) from 87 schools Huizhou. Height weight were measured, BMI calculated. Based on Chinese standards,...
Abstract Objective To evaluate whether the intense simplified strategy, which comprises short term intensive insulin therapy (SIIT) followed by subsequent oral antihyperglycaemic regimens, could improve long glycaemic outcomes in patients with newly diagnosed type 2 diabetes mellitus and severe hyperglycaemia. Design Multicentre, open label, randomised trial. Setting 15 hospitals China between December 2017 2020. Participants 412 significant hyperglycaemia (HbA 1c ≥8.5%). Interventions All...
Previous studies have reported that alcohol dehydrogenase (ADH) isoenzymes possess diagnostic value in gastric cancer (GC). However, the prognostic of ADH GC remains unclear. The aim present study was to identify genes patients with GC. investigated using Kaplan‑Meier plotter tool. plots were used assess difference between groups different prognoses. Hazard ratios (HR) and 95% confidence intervals (CI) relative risk survival. Overall, 593 7 included survival analysis. High expression 1A...
Abstract Background Fatty liver index (FLI) is the most recognized blood biomarker for diagnosis of hepatic steatosis (HS), but lacks reliable specific cut-off points (COPs). Therefore, we aim to investigate population-specific COPs FLI based on results ultrasound transient elastography (LUTE) and conventional ultrasonography in National Health Nutrition Examination Survey (NHANES). Methods 5948 participants who underwent LUTE from NHANES 2017–2018 14,797 Third (NHANES III) were recruited....
Objective To investigate the application value of 3T MRI qDixon-WIP technique in quantitative measurement pancreatic fat content patients with type 2 diabetes mellitus (T2DM). Methods The sequence was used to scan livers and pancreas 47 T2DM (experimental group) 48 healthy volunteers (control group). Pancreatic fraction (PFF), hepatic (HFF), Body mass index (BMI) ratio volume body surface area (PVI) were measured. Total cholesterol (TC), subcutaneous (SA), triglyceride (TG), abdominal...
Objective. Free triiodothyronine (FT3) is an independent risk factor for nonalcoholic fatty liver disease (NAFLD) in patients with euthyroid. However, whether FT3 has effect on NAFLD a population of type 2 diabetes remains unknown. The purpose this study was to identify the potential role T2DM. Design. A cross-sectional study. Patient. total 859 T2DM who met inclusion criteria were included. There 506 without and 353 NAFLD. Methods. samples <math xmlns="http://www.w3.org/1998/Math/MathML"...
This study aimed to explore the relationship between neuraxial labor analgesia and intrapartum fever demonstrate influence of maternal on perinatal outcomes within 6 weeks after birth.This was a secondary analysis multicenter prospective cohort that enrolled women with single- full-term cephalic pregnancy in northern China. Intrapartum defined as highest axillary temperature during ≥37.5°C. Data baseline characteristics, variables, neonatal were all collected. The association analyzed...
Background: Short-term intensive insulin therapy (SIIT) had immediate and significant effect on early type 2 diabetes mellitus (T2DM) control, but the benefit diminished over time. This study aimed to evaluate whether sequential oral antihyperglycemic regimens- comparing combination or mono-therapy lifestyle- following SIIT could further improve long-term outcomes.Methods: In this 48-week, multi-centre, open-label, randomised trial across 15 Chinese centres, newly diagnosed T2DM patients...
<title>Abstract</title> Fibrotic diseases, like non-alcoholic steatohepatitis (NASH), pose challenges for targeted delivery and retention of therapeutic proteins due to increased extracellular matrix (ECM) deposition. Here we present a new approach treat fibrotic termed “Fibrosis overexpression (FORT)”. In this two-step strategy, design 1) retinoid derivative lipid nanoparticle (LNP) enable specific mRNA in hepatic stellate cells, 2) modifications which facilitate anchoring the ECM. LNPs...
To compare the efficacy and safety of insulin degludec biosimilar B01411 (HS-IDeg) with originator degludec-Tresiba (NN-IDeg) in Chinese patients type 2 diabetes mellitus (T2DM) who were inadequately controlled on oral antidiabetic drugs (OADs) for at least 3 months.
To analyze the clinical and radiological characteristics of AIDS related pneumocystis jiroveci infection, pneumonia (AIDS-PCP). A total 15 patients with AIDS-PCP was recruited, 14 males 1 female. All CT data were collected all images retrospectively analyzed by two senior radiologists who are blind to patients' diagnosis. The findings categorized into 4 types: (1) Ground-glass opacities in cases (93%), diffuse distributed bilateral lungs; (2) Interstitial infiltrations 11 (73%), which mainly...
In the present study,healthy adults who had been residing at average altitudes of 6,2260,and 2800 m for 10 years were recruited,and number red blood cells,the levels hemoglobin,and HbA1C tested.The results showed that level in altitude group was higher compared with other 2 groups(5.80％ ± 0.50％ vs 5.39％ 0.47％,P＜0.05 ).Therefore,this difference should be considered when diagnosis and treatment diabetes mellitus made region. Key words: High altitude; Glycated hemoglobin
Abstract Background and aimsAn international expert consensus statement was released on 2020 that non-alcoholic fatty liver disease (NAFLD) should be replaced by metabolic associated (MAFLD) hepatic steatosis (HS) is fundamental for the diagnosis of MAFLD in new set criteria. While female breast cancer has surpassed lung as most commonly diagnosed malignant tumor shares same risk factors with HS MAFLD, but their prevalence survivors (BCS) unknown. Herein, we employed ultrasound elastography...
Dipeptidyl peptidase-4 inhibitors (DPP-4i) have become firmly established in treatment algorithms and national guidelines for improving glycemic control type 2 diabetes mellitus (T2DM).To report the findings from a multicenter, randomized, double-blind, placebo-controlled phase 3 clinical trial, which was designed to assess efficacy safety of novel DPP-4 inhibitor fotagliptin treatment-naive patients with T2DM.Patients T2DM were randomized receive (n = 230), alogliptin 113) or placebo 115)...
Abstract Background: The relationship between metabolic associated fatty liver disease (MAFLD) and thyroid nodule (TN) is unknown, despite the obese individuals showed a greater risk of nonalcoholic disease（NAFLD）and cancer compared to normal BMI individuals. . This cross-sectional study examining association TN MAFLD in healthy Chinese population undergoing simultaneous abdominal ultrasonography. Methods： A total 78077 with complete biochemical, ultrasonography data from Quality Control...
Abstract Background Human rhinovirus (HRV) is the predominant etiological agent of common cold in children and adults. A recent study showed that inhibitory effect face masks on viral shedding HRV was less prominent than other respiratory viruses. Considering most Chinese people have worn public area since outbreak coronavirus disease 2019, we aimed to find out whether prevailed among 2020 demonstrate details epidemiological features under such a special circumstance. Methods We summarized...