A5101677846- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Renal Diseases and Glomerulopathies
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Chronic Kidney Disease and Diabetes
- Vitamin D Research Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipose Tissue and Metabolism
- Hormonal Regulation and Hypertension
- Renal Transplantation Outcomes and Treatments
- MicroRNA in disease regulation
- Neuroblastoma Research and Treatments
- Parathyroid Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Growth Hormone and Insulin-like Growth Factors
- Glioma Diagnosis and Treatment
- Reproductive System and Pregnancy
- Glycosylation and Glycoproteins Research
- Gastric Cancer Management and Outcomes
- Metabolism and Genetic Disorders
- Adrenal and Paraganglionic Tumors
Nanjing Medical University
2015-2024
Jiangsu Province Hospital
2015-2024
The First Affiliated Hospital, Sun Yat-sen University
2013-2024
Sun Yat-sen University
2013-2024
Capital Medical University
2024
Tsinghua University
2024
Capital University
2024
University of Utah
2020-2021
The University of Texas Southwestern Medical Center
2018
Southwestern Medical Center
2018
OBJECTIVE—To investigate whether long-term optimal glycemic control can be achieved without medication by transient continuous subcutaneous insulin infusion (CSII) and the possible mechanisms responsible for this remission. RESEARCH DESIGN AND METHODS—Newly diagnosed type 2 diabetic patients (n = 138, fasting glucose >11.1mmol/l) were hospitalized treated with CSII weeks. Intravenous tolerance tests (IVGTTs) performed, blood glucose, HbA1c, lipid profiles, proinsulin, insulin,...
Recent studies have demonstrated that the expression of miR-34a is significantly upregulated and associated with cell apoptosis in pancreatic β -cell treated palmitate. Nevertheless, underlying detailed mechanism largely unknown. Here, we showed was induced Min6 upon palmitate treatment. Elevated promoted apoptosis. Intriguingly, ectopic lowered Bcl-2, an antiapoptotic protein. Luciferase reporter assay indicated direct interaction Bcl-2 3′-UTR. Moreover, downregulated by could be restored...
Our previous study has demonstrated that dietary arginine supplementation during early pregnancy enhanced embryo implantation in rats. However, the mechanism was not clear. The objective of this to determine pregnancy. Rats were fed basal diets supplemented with 1.3% (wt:wt) L-arginine-HCl or 2.2% L-alanine (isonitrogenous control) once On d4 pregnancy, rats given intrauterine injection L-NG-nitro methyl ester (L-NAME, nitric oxide synthase inhibitor), α-difluoromethylornithine (DFMO,...
OBJECTIVE Short-term intensive insulin treatment in patients with newly diagnosed type 2 diabetes can improve β-cell function and sensitivity, which results long-term remission without need for further antidiabetes medication. Patient attitudes toward their disease were assessed using the Diabetes Care Profile (DCP) tool to evaluate potential impact on maintaining remission. RESEARCH DESIGN AND METHODS Newly recruited treated continuous subcutaneous infusion (CSII) 2–3 weeks. They also...
No drug has been shown to be effective in preventing cardiac surgery-associated acute kidney injury (CSA-AKI). In different clinical settings, sodium-glucose transporter 2 (SGLT2) inhibitors confer renal protection and may promising candidates. We examined the association between preoperative dapagliflozin use incidence prognosis of CSA-AKI. Data were obtained for consecutive patients undergoing surgery with cardiopulmonary bypass December 2020 November 2022 at a large teaching hospital...
Accumulating evidence suggests that some microRNAs (miRNAs) are involved in papillary thyroid carcinoma (PTC) progression. However, it remains necessary to elucidate the underlying molecular mechanisms involved. In present study, we investigated role of microRNA-101 (miR-101) PTC via targeting Ras-related C3 botulinum toxin substrate 1 (Rac1). The results showed miR-101 was significantly downregulated tissues compared with adjacent normal tissues. Restoration expression inhibited cell...
Background/Objectives Renaming non-alcoholic fatty liver disease (NAFLD) to metabolic dysfunction-associated (MAFLD) suggests a shift of emphasis the accompanying disturbance. Controlled attenuation parameter (CAP) measured by FibroScan has been shown be correlated with hepatic steatosis. We aim validate its usefulness as novel surrogate marker for evaluating derangement. Subjects/Methods Volunteers were recruited from medical staff at our hospital undergo CAP measurements. Anthropometrics,...
Abstract Aims To evaluate the clinical profile of patients with diabetic ketoacidosis in tertiary hospitals China. Methods A retrospective study hospitalized between 2010 and 2012 was carried out 15 around Clinical laboratory data were collected. Patients classified based on diagnosis treatment history. Groups compared for differences vital statistics biochemical profiles at presentation. Results The comprised 643 ketoacidosis: 308 (47.9%) Type 1 diabetes, 294 (45.7%) 2 diabetes 41 (6.4%)...
N-carbamylglutamate (NCG) has been shown to enhance performance in neonatal piglets. However, few studies have demonstrated the effect of NCG on intestinal mucosal barrier. This study was conducted determine effects dietary supplementation immunity piglets after an Escherichia coli (E. coli) challenge. New-born (4 d old) were assigned randomly one four treatments (n = 7), including (I) sham challenge, (II) challenge +50 mg/kg NCG, (III) E. and (IV) NCG. On 8, pigs groups (III IV) orally...
To explore angiopoietin-like protein 8 (ANGPTL-8) levels, and its association with hepatocellular lipid content (HCL) insulin resistance in patients different extents of non-alcoholic fatty liver disease (NAFLD).In 48 adults were recruited, which 12 had no NAFLD (HCL < 5.5%; group 1), 18 mild (5.5% ≤ HCL 10.0%; 2) moderate-to-severe ≥ 3). The peripheral sensitivity all participants was monitored by a hyperinsulinemic-euglycemic clamp (M value), as well the magnetic resonance image HCL. Serum...
Short-term continuous subcutaneous insulin infusion (CSII) in patients with newly diagnosed type 2 diabetes has been proved effective improving metabolic control and β-cell function, thus inducing long-term drug-free remission. A randomized controlled trial was conducted to investigate whether CSII combination rosiglitazone, metformin, or α-lipoic acid separately brings about extra benefits.One hundred sixty were one of four treatment groups: alone, rosiglitazone metformin for 3 months,...
Objectives As accumulating data supporting the potential role of complement system in pathogenesis diabetic kidney disease (DKD), present study aimed to explore association glomerular C4 deposition with baseline clinicopathological characteristics and prognosis DKD type 2 diabetes (T2DM) patients. Methods A total 79 T2DM patients biopsy-proven were enrolled. Clinicopathological features renal outcomes compared between groups divided by C4c patterns median values serum C4. Renal defined...
Elevated 1-h postload plasma glucose concentration (1hPG) during oral tolerance test has been linked to an increased risk of type 2 diabetes and a poorer cardiometabolic profile. The present study analyzed the predictability cut-off point 1hPG in predicting normal regulation (NGR) subjects, evaluated long-term prognosis NGR subjects with elevated metabolism, kidney function, metabolic states atherosclerosis.A total 116 Han Chinese classified as 2002 at First Affiliated Hospital Sun Yat-sen...
Background: Short-term intensive insulin therapy has been shown to induce long-term glycemic remission in patients with newly diagnosed type 2 diabetes. However, predictors of are still uncertain. This study was conducted evaluate whether changes 1,5-anhydroglucitol (1,5AG) and fructosamine (FA) could be a predictor remission. Subjects Methods: Newly drug-naive diabetes (n=64) were enrolled. After baseline assessments, continuous subcutaneous infusion (CSII) administered all until euglycemia...
Abstract Objective To evaluate whether the intense simplified strategy, which comprises short term intensive insulin therapy (SIIT) followed by subsequent oral antihyperglycaemic regimens, could improve long glycaemic outcomes in patients with newly diagnosed type 2 diabetes mellitus and severe hyperglycaemia. Design Multicentre, open label, randomised trial. Setting 15 hospitals China between December 2017 2020. Participants 412 significant hyperglycaemia (HbA 1c ≥8.5%). Interventions All...
Mutations in the insulin receptor (IR) gene are known to cause severe resistance. Although clinical features due a mutation can be diverse, hypoglycaemia is found some cases. A family with female proband diagnosed type resistance syndrome was studied. Clinical characteristics were compared Arginine1174Glutamine (R1174N) reported literature.The 16-year-old girl who presented intermittent hypoglycaemia, hirsutism, darkened skin, acne and oligomenorrhoea. 5-h oral glucose tolerance test (OGTT),...
Abstract Aims/Introduction To investigate the effects of vitamin D and its receptor on cytokines expression podocytes apoptosis. Materials Methods Cultured mouse were pre‐incubated with or transiently transfected small interfering ribonucleic acid (RNA) to knock down receptor. Lipopolysaccharide was used mimic inflammation status diabetes. Results In a lipopolysaccharide‐induced state, expressions transforming growth factor‐β, angiotensinogen vascular endothelial factor similarly increased....
Abstract Recent identification of an RNA-binding protein (HuR) that regulates mRNA turnover and translation numerous transcripts via binding to ARE in their 3′-UTR involved inflammation is abnormally elevated varied kidney diseases offers a novel target for the treatment renal subsequent fibrosis. Thus, we hypothesized with selective inhibition HuR function small molecule, KH-3, would down-regulate HuR-targeted proinflammatory thereby improving glomerulosclerosis experimental nephritis,...
Objectives Growing evidence demonstrated that vitamin D levels had been linked to type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) in light of various extraskeletal effects. Therefore, the present study aimed evaluate association 25-hydroxyvitamin [25(OH)D] level with clinicopathological features CKD progression T2DM. Methods A total 182 patients T2DM stages 1 through 4 (G1–G4) were retrospectively included. Identification serum 25(OH)D associated was executed by Kaplan–Meier...