A5051660185- Polymer Surface Interaction Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Mesenchymal stem cell research
- Neurogenesis and neuroplasticity mechanisms
- Nanoparticle-Based Drug Delivery
- Advanced X-ray Imaging Techniques
- Angiogenesis and VEGF in Cancer
- Acute Ischemic Stroke Management
- Advanced Sensor and Energy Harvesting Materials
- Ginseng Biological Effects and Applications
- Electrochemical sensors and biosensors
- Advanced MRI Techniques and Applications
- Cancer-related molecular mechanisms research
- Axon Guidance and Neuronal Signaling
- Neurological Disease Mechanisms and Treatments
- Immune Cell Function and Interaction
- Electrospun Nanofibers in Biomedical Applications
- Cerebrovascular and Carotid Artery Diseases
- Conducting polymers and applications
- Surface Modification and Superhydrophobicity
- Cell death mechanisms and regulation
- Microbial Fuel Cells and Bioremediation
Shandong University
2023-2025
Qilu Hospital of Shandong University
2023-2024
University of Washington
2017-2024
Second Affiliated Hospital of Shantou University Medical College
2024
Shantou University
2024
Shenyang Pharmaceutical University
2018-2023
Zhejiang Chinese Medical University
2007-2021
Qingdao Eighth People's Hospital
2020-2021
Shanghai Jiao Tong University
2011-2019
The University of Tokyo
2011-2016
Superhydrophilic zwitterionic polymers derived from trimethylamine N -oxide are reported as a new class of nonfouling materials.
Abstract Background Postoperative cognitive dysfunction (POCD) is a common neurological complication of anesthesia and surgery in aging individuals. Neuroinflammation has been identified as hallmark POCD. However, safe effective treatments POCD are still lacking. Itaconate an immunoregulatory metabolite derived from the tricarboxylic acid cycle that exerts anti-inflammatory effects by activating nuclear factor erythroid 2-related 2 (Nrf2) pathway. In this study, we investigated underlying...
Mesenchymal stem cell (MSC) transplantation has been shown to be beneficial in treating cerebral ischemia. However, such benefit is limited by the low survival of transplanted MSCs an ischemic microenvironment. Previous studies showed that melatonin pretreatment can increase MSC kidney. whether it will improve ischemia unknown. Our study examined effect on under ischemia-related conditions vitro and after into rat brain. Results greatly increased reduced their apoptosis Melatonin-treated...
Abstract Poly(ethylene glycol) (PEG) conjugation has been the gold standard to ameliorate pharmacokinetic (PK) and immunological profiles of proteins. PEG polymer does become immunogenic once attached proteins, evoking PEG‐specific antibody (Ab) responses. The anti‐PEG Abs could cause PEGylated biologic treatments fail even result in lethal adverse reactions. Thus zwitterionic poly(carboxybetaine) (PCB) introduced as a substitute for protein modification. Addressed herein is anti‐polymer Ab...
Quantitatively tracking engraftment of intracerebrally or intravenously transplanted stem cells and evaluating their concomitant therapeutic efficacy for stroke has been a challenge in the field cell therapy. In this study, first, an MRI/SPECT/fluorescent tri‐modal probe ( 125 I‐fSiO4@SPIOs) is synthesized quantitatively mesenchymal (MSCs) into rats, then MSCs delivered by both routes possible mechanism therapy are evaluated. It demonstrated that (125) I‐fSiO4@SPIOs have high efficiency...
Neural stem cells (NSCs) show therapeutic potential for ischemia in young-adult animals. However, the effect of aging on NSC therapy is largely unknown. In this work, NSCs were transplanted into aged (24-month-old) and (3-month-old) rats at 1 day after stroke. Infarct volume neurobehavioral outcomes examined. The number differentiated was compared ischemic angiogenesis neurogenesis also determined. We found that developed larger infarcts than ( P<0.05). outcome worse comparing with rats....
We achieved ultralow fouling on target surfaces by controlled polymerization of carboxybetaine under ambient conditions. The process for grafting polymer films onto the was carried out in air and did not require any deoxygenation step or specialized equipment. This method allows one to conveniently introduce a nonfouling network large substrates.
An innovative biomimetic polymer integrates zwitterionic non-fouling properties with immunomodulatory functionality.
Netrin-1 (NT-1) stimulates endothelial cell proliferation and migration in vitro promotes focal neovascularization the adult brain vivo. This vivo study mice investigated effect of NT-1 hyperexpression on angiogenesis long-term functional outcome after transient middle cerebral artery occlusion (tMCAO).Adeno-associated viral vectors carrying either gene (AAV-NT-1) or GFP (AAV-GFP) were generated injected into brains separate groups 93 mice. Seven days later, tMCAO followed by 7-28...
The commonly used "stealth material" poly(ethylene glycol) (PEG) effectively promotes the pharmacokinetics of therapeutic cargos while reducing their immune response. However, recent studies have suggested that PEG could induce adverse reactions, including emergence anti-PEG antibodies and tissue histologic changes. An alternative stealth material with no or less immunogenicity organ toxicity is thus urgently needed. We designed a polypeptide high zwitterion density (PepCB) as for...
Photoreactive polymers bearing zwitterionic phosphorylcholine and benzophenone groups on the side chain were synthesized used as surface modification reagents for biomaterials. A photoreactive methacrylate containing group, 3-methacryloyloxy-2-hydroxypropyl-4-oxybenzophenone (MHPBP), was via a ring-opening addition reaction between glycidyl 4-hydroxybenzophenone. Then, water-soluble, amphiphilic poly(2-methacryloyloxyethyl (MPC)-co-MHPBP) (PMH) poly(MPC-co-n-butyl methacrylate-co-MHPBP),...
Abstract For biotherapeutics that require multiple administrations to fully cure diseases, the induction of undesirable immune response is one common cause for failure their treatment. Covalent binding hydrophilic polymers proteins commonly employed mitigate potential responses. However, while this technique proved partially reduce antibodies (Abs) reactive proteins, it may induce Abs toward associated and thus result in loss efficacy. Zwitterionic poly(carboxybetaine) (PCB) recently shown...
Background and Purpose— Acute interventions of stroke are often challenged by a narrow treatment window. In this study, we explore treatments in the postacute phase with wider windows opportunity. We investigated effects stromal cell–derived factor (SDF-1α) neurovascular recovery during downstream signaling pathways, underlying SDF-1α–mediated recovery. Methods— Adult male Institute Cancer Research (ICR) mice underwent middle cerebral artery occlusion. One week after occlusion, animals...
Here, we report a simple yet effective surface-modification approach to imparting hydrophobic surfaces with superhydrophilicity using ultralow fouling/functionalizable carboxybetaine (CB) copolymers via dip-coating technique. A new series of CB random varying amphiphilicities were synthesized and coated on polypropylene (PP) polystyrene (PS) surfaces. The nonfouling capability each coating was screened by an enzyme-linked immunosorbent assay (ELISA) further comprehensively assessed against...
Recent studies have demonstrated that the expression of miR-34a is significantly upregulated and associated with cell apoptosis in pancreatic β -cell treated palmitate. Nevertheless, underlying detailed mechanism largely unknown. Here, we showed was induced Min6 upon palmitate treatment. Elevated promoted apoptosis. Intriguingly, ectopic lowered Bcl-2, an antiapoptotic protein. Luciferase reporter assay indicated direct interaction Bcl-2 3′-UTR. Moreover, downregulated by could be restored...
While hydrophobic nanoparticles (NPs) have been long recognized to boost the immune activation, whether hydrophilic NPs modulate an system challenged by stimulators and how their properties may affect response is still unclear. To answer this question, three polymers, poly(ethylene glycol) (PEG), poly(sulfobetaine) (PSB) poly(carboxybetaine) (PCB), which are commonly considered hydrophilic, studied in work. For comparison, nanogels with uniform size homogeneous surface functionalities were...
Medical devices face nonspecific biofouling from proteins, cells, and microorganisms, which significantly contributes to complications device failure. Imparting these with nonfouling capabilities remains a major challenge, particularly for those made elastomeric polymers. Current strategies, including surface coating copolymerization/physical blending, necessitate compromise among properties, durability, mechanical strength. Here, new strategy is reported achieve both high bulk strength...
Blood contact with high surface area medical devices, such as dialysis and extracorporeal life support (ECLS), induces rapid coagulation. Systemic anticoagulation, heparin, is thus necessary to slow clot formation, but some patients suffer from bleeding complications. Both problems might be reduced by 1) replacing heparin anticoagulation artificial inhibition of the protein adsorption that initiates coagulation 2) selective intrinsic branch cascade. This approach was evaluated comparing...