A5100429394- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Thyroid Cancer Diagnosis and Treatment
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Diabetes Management and Research
- Pituitary Gland Disorders and Treatments
- Ophthalmology and Eye Disorders
- Chronic Disease Management Strategies
- Viral gastroenteritis research and epidemiology
- Cardiovascular Function and Risk Factors
- Cytokine Signaling Pathways and Interactions
- Adipose Tissue and Metabolism
- Influenza Virus Research Studies
- Diabetes Management and Education
- S100 Proteins and Annexins
- Hormonal Regulation and Hypertension
- Cardiac, Anesthesia and Surgical Outcomes
- Extracellular vesicles in disease
- Cancer, Lipids, and Metabolism
- Respiratory viral infections research
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
Affiliated Hospital of Guizhou Medical University
2025
People’s Hospital of Linqing
2024
Guangxi University of Chinese Medicine
2024
Ningxia Medical University
2016-2023
Nanjing Medical University
2010-2023
Jiangsu Province Hospital
2019-2023
Huazhong University of Science and Technology
2019-2023
Central Hospital of Wuhan
2019-2023
The relationship between the expression levels of matrix metalloproteinase-2 (MMP-2) and MMP-9 breast cancer prognosis was studied. Two cell lines (MDA-MB-231 MCF-7) one human normal line (HS578Bst) were investigated. Fluorescence real-time reverse transcription-polymerase chain reaction (RT-PCR) western blotting used to detect cellular mRNA protein MMP-2 levels. Breast tissue samples from 80 patients tumor-adjacent 40 collected, in these examined using immunohistochemistry (IHC). with...
Abstract: Interleukin-22 (IL-22), which acts as either a proinflammatory or anti-inflammatory cytokine in various disease models, is markedly up-regulated chronic liver diseases, including hepatitis B and C. In this report, we demonstrate strong correlation between IL-22 expression the with active, inflammatory human disease. To clarify role of up-regulation pathogenesis liver-specific transgenic (IL-22TG) mice, under control albumin promoter, were developed. Despite elevated serum levels...
Recent studies have demonstrated that the expression of miR-34a is significantly upregulated and associated with cell apoptosis in pancreatic β -cell treated palmitate. Nevertheless, underlying detailed mechanism largely unknown. Here, we showed was induced Min6 upon palmitate treatment. Elevated promoted apoptosis. Intriguingly, ectopic lowered Bcl-2, an antiapoptotic protein. Luciferase reporter assay indicated direct interaction Bcl-2 3′-UTR. Moreover, downregulated by could be restored...
Mounting evidence has showed that Tumor-associated calcium signal transducer 2 (Trop2) is upregulated in various kinds of human cancers and plays important roles tumorigenesis. However, the expression status functional significance Trop2 thyroid cancer are largely unknown. We first determined by using RNAseqV2 data sets for deposited on The Cancer Genome Atlas (TCGA) website. was then confirmed real-time reverse transcription-polymerase chain reaction (RT-PCR) immunohistochemistry assays....
Background: The clinical impact of heart failure (HF) on postoperative outcomes following video-assisted thoracic surgery (VATS) for lung cancer resection remains controversial. This study aimed to assess patient and hospital characteristics related the type surgery, as well independent HF surgical outcomes. Methods: We conducted a retrospective analysis using data from National Inpatient Sample database. A total 20 693 patients aged 18 years or older, diagnosed with cancer, undergoing...
// Jian Wang 1, 2, * , Hai Li 3, Yong 2 Libin Xiurui Yan Dong Zhang 3 Xiaoqiang Ma Du 1 Xiaoming Liu Yinxue Yang The general hospital, Ningxia Medical University, Yinchuan 750004, China Human Stem Cell Institute of the General Hospital at Department Colorectal Surgery, These authors contributed equally to this work Correspondence to: Yang, email: nyfyyyx@126.com Liu, liuxiaoming@nxmu.edu.cn erc1080@163.com Keywords: microRNAs, colorectal cancer, miR-552, antagomir, ADAM28 Received: January...
Abstract Background Papillary thyroid carcinoma (PTC) is the main pathological type of (TC). Gender a prominent background parameter for patients with PTC. Here, we aimed to delineate differences in cell clusters and immune microenvironment relation gender Methods We generated 6720, 14,666, 33,373 single-cell transcriptomes that were pooled from tissues four male PTC, seven female three nodular goiter, respectively. performed RNA-sequencing (scRNA-seq) based on BD Rhapsody characterized...
Tumor microenvironment interacts with gastric cancer (GC) cells and affects tumor development.The communication between GC fibroblasts has not been clearly studied understood.MiR-10b-5p was found highly expressed in tissue serum samples of patients advanced stages (stage III+IV) than that early stage I+II).The expression determination exosomal microRNA also shown high miR-10b-5p stages.Dual-luciferase activity assays indicated targeted PTEN KLF11 fibroblasts.The silence up-regulated the...
Atrial fibrillation (AF) is the most common arrhythmia in world. Long noncoding RNA (lncRNA) has been found to play an important role cardiovascular diseases including heart failure, myocardial infarction, and atherosclerosis. However, of lncRNA AF rarely studied. The purpose this study identify expression profile patients, explore function AF, provide a potential scientific basis for treatment future. mRNA profiles were obtained from atrial appendage samples GSE31821, GSE411774, GSE79768,...
Abstract Background Chronic refractory wounds easily relapse and seriously affect the patients’ quality of life. Previous studies have shown that stromal vascular fraction gel (SVF-gel) significantly promotes early healing chronic wounds; however, mechanisms SVF-gel function per se remain unclear, a long-term follow-up is lacking. This study aims to explore promoting follow up efficacy SVF-gel. Methods Autologous transplantation was performed in 20 patients with (from March 2016 September...
Accumulating evidence suggests that some microRNAs (miRNAs) are involved in papillary thyroid carcinoma (PTC) progression. However, it remains necessary to elucidate the underlying molecular mechanisms involved. In present study, we investigated role of microRNA-101 (miR-101) PTC via targeting Ras-related C3 botulinum toxin substrate 1 (Rac1). The results showed miR-101 was significantly downregulated tissues compared with adjacent normal tissues. Restoration expression inhibited cell...
The natural history of chronic hepatitis B virus (HBV) infection was divided into 4 phases. Patients in the inactive carrier (IC) status and immune tolerant (IT) phase had normal alanine aminotransferase levels but huge different viral loads. mechanism underlying low replication IC is unknown.We determined intrahepatic transcriptomes 83 patients by microarray analysis liver biopsies, screened effect differentially regulated genes on HBV using specific small interfering RNAs vitro.The gene...
Long non-coding RNAs (lncRNAs) are known to competitively bind with microRNAs (miRNAs) participate in human cancers. We aim explore the role of RNA activated by DNA damage (NORAD) binding miR-323a-3p breast cancer (BC) involvement pumilio RNA-binding family member 1 (PUM1)/eukaryotic initiation factor 2 (eIF2) axis. Expression NORAD, and PUM1 tissues cell lines was detected, correlation between NORAD expression clinicopathological features BC patients analyzed. The screened line respectively...
Transmembrane protease serine 4 (TMPRSS4), one of the type II transmembrane proteases (TTSPs), is elevated in various cancers and associated with multiple malignant phenotypes. However, expression pattern biologic significance TMPRSS4 thyroid cancer are largely unknown. In this study, we investigated assessed pro-proliferative role cancer.Immunohistochemistry real-time reverse transcription-polymerase chain reaction (RT-PCR) assays were performed to assess cancer. We evaluated vitro cell...
Tight glycemic control during short-term intensive insulin therapy (SIIT) is critical for inducing diabetes remission in patients with newly diagnosed type 2 (T2D). This work aimed to investigate the role of time range (TIR) SIIT as a novel target by predicting clinical outcomes.SIIT was given 116 T2D, daily eight-point capillary glucose monitored. Glycemic targets (fasting/premeal glucose, 3.9-6.0 mmol/L; h postprandial blood 3.9-7.8 mmol/L) were achieved and maintained weeks. TIRPIR...
Abstract Objective To evaluate whether the intense simplified strategy, which comprises short term intensive insulin therapy (SIIT) followed by subsequent oral antihyperglycaemic regimens, could improve long glycaemic outcomes in patients with newly diagnosed type 2 diabetes mellitus and severe hyperglycaemia. Design Multicentre, open label, randomised trial. Setting 15 hospitals China between December 2017 2020. Participants 412 significant hyperglycaemia (HbA 1c ≥8.5%). Interventions All...
Background: Recent studies have highlighted the important roles of long non-coding RNAs (lncRNAs) in pancreatic adenocarcinoma (PCa) prognosis. However, most explored a limited number lncRNAs based on small sample size. Methods: Systematic and comprehensive analysis data from The Cancer Genome Atlas (TCGA) was performed to identify panel lncRNA signature for predicting prognosis PCa. Results: A total 160 PCa patients with complete clinical were included our study. Twelve identified be...
Prostate cancer is one of the leading causes death in males. Recent studies have reported aberrant expression lncRNAs prostate cancer. This study explores role LINC00261 progression.The differentially expressed genes, transcription factors, and related to were predicted by bioinformatics analysis. tissue samples cell lines collected for determination reverse quantitative polymerase chain reaction. The binding capacity factor GATA6 was detected RIP, DKK3 promoter region assessed ChIP. In...
Graves' orbitopathy (GO) causes infiltrative exophthalmos by inducing excessive proliferation, adipogenesis, and glycosaminoglycan production in orbital fibroblasts (OFs). Interference with OF autophagy is a potential therapy for proptosis.Here, we aimed to evaluate the effects of chloroquine (CQ) hydroxychloroquine (HCQ), inhibitors commonly used clinical practice, on OFs.OFs isolated from patients GO (GO-OFs) or control individuals (non-GO-OFs) were cultured proliferation medium (PM)...