A5011699827- Renal Transplantation Outcomes and Treatments
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Immunotherapy and Immune Responses
- Renal Diseases and Glomerulopathies
- Cytomegalovirus and herpesvirus research
- Liver Disease and Transplantation
- SARS-CoV-2 and COVID-19 Research
- Immune Response and Inflammation
- Complement system in diseases
- Polyomavirus and related diseases
- Blood groups and transfusion
- interferon and immune responses
- Neurological Complications and Syndromes
- Systemic Lupus Erythematosus Research
- Cell Adhesion Molecules Research
- HIV Research and Treatment
- Virology and Viral Diseases
- Monoclonal and Polyclonal Antibodies Research
- Immunodeficiency and Autoimmune Disorders
- Pregnancy and Medication Impact
- Drug-Induced Adverse Reactions
- Clinical Laboratory Practices and Quality Control
Hôpital Purpan
2018-2025
Inserm
2012-2025
Université Toulouse III - Paul Sabatier
2015-2025
Centre de Recherche en Cancérologie de Toulouse
2020-2025
Centre Hospitalier Universitaire de Toulouse
2012-2024
Hôpital Rangueil
2012-2024
Université de Toulouse
2020-2024
Université de Strasbourg
2022
Institut de Pharmacologie et de Biologie Structurale
2022
Centre National de la Recherche Scientifique
2017
<b>Objectives</b> To assess the long term outcomes of transplantation using expanded criteria donors (ECD; aged ≥60 years or 50-59 with vascular comorbidities) and main determinants its prognosis. <b>Design</b> Prospective, population based cohort study. <b>Setting</b> Four French referral centres. <b>Participants</b> Consecutive patients who underwent kidney between January 2004 2011, were followed up to May 2014. A validation included from another four centres in France 2002 December 2011....
ABSTRACT HLA‐DRB3*02:213 differs from DRB3*02:02 by one nucleotide substitution in codon 6 exon 2.
Little is known about the impact of posttransplant blood transfusion on sensitization anti-HLA antibodies and formation donor-specific (DSAs). The aims our study were to determine 1-year incidence DSAs (assessed using a solid-phase assay) antibody-mediated rejection (AMR) in kidney transplant patients who had or not received during first year after transplantation. Included 390 non-HLA-sensitized an ABO-compatible previously simultaneously nonkidney transplant. Overall, 64% red cell within...
AIMTo investigate the role of tacrolimus intra-patient variability (IPV) in adult liver-transplant recipients. METHODSWe retrospectively assessed a cohort recipients and analyzed its effect on occurrence graft rejection de novo donor-specific antibodies (dn DSAs), as well
Anti–severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination is recommended in patients who underwent a transplant because of an increased risk developing severe disease 2019 (COVID-19), and mortality.1Caillard S. Anglicheau D. Matignon M. et al.An initial report from the French SOT COVID Registry suggests high mortality due to COVID-19 recipients kidney transplants.Kidney Int. 2020; 98: 1549-1558Abstract Full Text PDF PubMed Scopus (197) Google Scholar Because weak...
Abstract The identity of histocompatibility loci, besides human leukocyte antigen ( HLA ), remains elusive. major complex (MHC) class I MICA gene is a candidate locus. Here, we investigate its role in French multicenter cohort 1,356 kidney transplants. mismatches were associated with decreased graft survival (hazard ratio (HR), 2.12; 95% confidence interval (CI): 1.45–3.11; P < 0.001). Both before and after transplantation anti-MICA donor-specific antibodies (DSA) strongly increased...
Antibody-mediated rejection (AMR) that resists to standard of care (SOC) therapy remains a major challenge after kidney transplantation and leads graft failure in majority cases. The use anti-IL6 receptor antibodies was suggested treat chronic antibody-mediated (cAMR) classical treatments. We treated nine patients with AMR resistant apheresis, rituximab, intravenous immunoglobulins, monthly infusion tocilizumab compared them historical cohort 37 similar clinical, immunological, histological...
Introduction The occurrence of de novo anti-human leukocyte antigen (HLA) antibodies and donor-specific (DSAs) after early graft loss is not well known. aims this single-center study were to evaluate the incidence DSAs non-DSA anti-HLA allograft nephrectomy for seek predictive factors development DSAs. Materials Methods Thirty-two patients, who experienced an (<3 months transplantation) required nephrectomy, considered retransplantation, included in study. Anti-HLA assessed, using Luminex...
The data presented in this paper are reference ranges for frequencies of thirty-eight subpopulations T, B and NK lymphocytes, established from a cohort 253 healthy blood donors aged 19 to 67. When relevant, the influence age or sex was taken into account calculate these values. This article is related research entitled "Influence age, HCMV-serostatus on lymphocyte adults" (Apoil et al., 2017) [1]. Immunophenotyping obtained each individual made publicly available extended analyses.
BackgroundType I interferon (IFN-I) production by plasmacytoid dendritic cells (pDCs) occurs during viral infection, in response to Toll-like receptor 7 (TLR7) stimulation and is more vigorous females than males. Whether this sex bias persists ageing people currently unknown. In study, we investigated the effect of aging on IFN-α induced PRR agonist ligands.MethodsIn a large cohort individuals from 19 97 years old, measured inflammatory cytokines whole-blood upon with either R-848, ODN M362...
Systemic lupus erythematosus (SLE) is a systemic autoimmune/inflammatory disease with strong genetic component. Genetic burden higher in children when compared to patients adult-onset SLE, contributing earlier expression and more severe phenotypes. The human leukocyte antigen (HLA) cluster on chromosome 6p21.3 among the most variable genomic regions, representing major risk-factor for SLE adults. Its impact juvenile-onset (j)SLE remains largely unstudied. High-resolution sequencing of HLA...
Anti-denatured HLA-Cw antibodies are highly prevalent, whereas anti-native seem to lead random flow cytometry crossmatch results. We aimed reassess prediction for anti-HLA-Cw using 2 types of single antigen beads (classical and with diminished expression denatured HLA), compare the pathogenicity preformed anti-denatured in kidney transplantation. performed 135 crossmatches sera reacting against donor fluorescence ≥500); only 20.6% were positive. Forty-three (31.6%) HLA (beads <300); all...
HLA‐DQB1*03:512 differs from DQB1*03:02:01 by one nucleotide substitution in codon 89 exon 2.
HLA‐DRB1*14:253 differs from DRB1*14:54:01 by one nucleotide substitution in codon 233 exon 5.
IntroductionDe novo DSA (dnDSA) is a strong biomarker associated with the development of antibody mediated rejection and graft loss after kidney transplantation. Although this procedure expensive, systematic annual screening was recommended by some national organ transplant agencies or societies though its clinical utility not clearly established.MethodsTo address question, we retrospectively assessed incidence dnDSA according to test justification (clinically indicated systematic) in cohort...
HLA‐DQA1*02:32 differs from DQA1*02:01:01 by one nucleotide substitution in codon 210 exon 4.
We analyzed the impact of age, sex, and CMV on blood monocyte dendritic cell (DC) subpopulations in 256 healthy individuals aged from 19 to 96 years. Flow cytometry was performed whole within 4 h following drawing. Myeloid (mDC) plasmacytoid DC (pDC), classical, intermediate, nonclassical monocytes were enumerated by means TruCount tubes (BD Biosciences). provided reference values for mDC, pDC three subpopulations. The numbers slightly increased with age while mDC did not vary significantly....
After liver transplantation (LT), the role of preformed donor‐specific anti–human leukocyte antigen antibodies (pDSAs) remains incompletely understood. We conducted a retrospective, case‐control analysis to determine impact pDSAs after LT in 3 French transplant centers (Bordeaux, Lyon, and Toulouse). Among 1788 LTs performed during study period, 142 (7.9%) had at least 1 pDSA. The patient survival rate was not different between patients who received an with matched‐control group. A biopsy...
IntroductionImlifidase is authorized for desensitization of highly sensitized adult kidney transplant candidates with a positive crossmatch (XM) against deceased donor. Here, we report on the results first 9 patients transplanted in this context who had at least 3 months follow-up.MethodsThe eligibility criteria were as follows: calculated panel reactive antibodies (cPRA) ³ 98%, years waiting list, immunodominant donor-specific (DSAs) mean fluorescence intensity (MFI) > 6000 (and < 5000 1:10...
The reasons for the increased incidence of de novo anti-human leukocyte antibody (HLA) donor-specific antibodies (DSAs) observed after kidney allograft nephrectomy are not fully understood. One advocated mechanism suggests that at graft loss, DSAs detected in serum because they fixed on nonfunctional transplant; removal allows to then appear blood circulation. aim our study was compare anti-HLA present and time an nephrectomy. Using solid-phase assays, were searched sera 17 transplant...